ID F6TSV9_HORSE Unreviewed; 796 AA.
AC F6TSV9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Toll-like receptor {ECO:0000256|RuleBase:RU363040};
GN Name=TLR6 {ECO:0000313|Ensembl:ENSECAP00000001398.3,
GN ECO:0000313|VGNC:VGNC:49327};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000001398.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000001398.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000001398.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000001398.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000001398.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU363040}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU363040}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595,
CC ECO:0000256|RuleBase:RU363040}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363040}.
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DR AlphaFoldDB; F6TSV9; -.
DR STRING; 9796.ENSECAP00000001398; -.
DR PaxDb; 9796-ENSECAP00000001398; -.
DR Ensembl; ENSECAT00000001932.3; ENSECAP00000001398.3; ENSECAG00000001958.3.
DR Ensembl; ENSECAT00000079481.1; ENSECAP00000082780.1; ENSECAG00000001958.3.
DR Ensembl; ENSECAT00000083733.1; ENSECAP00000065256.1; ENSECAG00000001958.3.
DR Ensembl; ENSECAT00000094259.1; ENSECAP00000066516.1; ENSECAG00000001958.3.
DR Ensembl; ENSECAT00000099374.1; ENSECAP00000069347.1; ENSECAG00000001958.3.
DR Ensembl; ENSECAT00000103019.1; ENSECAP00000080794.1; ENSECAG00000001958.3.
DR Ensembl; ENSECAT00000103665.1; ENSECAP00000067936.1; ENSECAG00000001958.3.
DR Ensembl; ENSECAT00000137400.1; ENSECAP00000059938.1; ENSECAG00000001958.3.
DR Ensembl; ENSECAT00000145185.1; ENSECAP00000077687.1; ENSECAG00000001958.3.
DR VGNC; VGNC:49327; TLR6.
DR GeneTree; ENSGT00940000162201; -.
DR HOGENOM; CLU_006000_3_0_1; -.
DR InParanoid; F6TSV9; -.
DR OMA; CHHEKNF; -.
DR TreeFam; TF351113; -.
DR Proteomes; UP000002281; Chromosome 3.
DR Bgee; ENSECAG00000001958; Expressed in blood and 20 other cell types or tissues.
DR GO; GO:0035355; C:Toll-like receptor 2-Toll-like receptor 6 protein complex; IBA:GO_Central.
DR GO; GO:0071723; F:lipopeptide binding; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0035663; F:Toll-like receptor 2 binding; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0071726; P:cellular response to diacyl bacterial lipopeptide; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF422; TOLL-LIKE RECEPTOR 6; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01463; LRRCT; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|RuleBase:RU363040};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|RuleBase:RU363040};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363040}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT TRANSMEM 585..609
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363040"
FT DOMAIN 640..781
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 796 AA; 91545 MW; 769F9724FDD7718F CRC64;
MTKDNKCVVR IFNFVYIVTL IVGTIIQFSD ESKFAVDMSK IGLTHVLKDL PPETKVLDMS
QNCISELHLS DMSFLSGLKV LRLSRNSIRY LDFSIFKFNP DLEYLDLSHN QLQKISCHPI
MSLKHLDLSF NDFEVLPICK EFGNLTQLDF LGLSATRLQQ LDLLPIAHLH LSCILLDLEG
YYVKENQTES LQIPNTKTLQ LVFHPYNLFS VQVNISLNSL GCLQLTNIKL NDDNCQVLIK
FLSDPIRQPT LLNITLNHVE TTWKCLVRVF QFLWPKPVES LHICNLTIVK SIGKEDFTYS
KTALKALKIE HITNRVYIFS QQVLYTVFSE MNIMMLTISD TPFIHMVCPQ APSTFKFLNF
TQNVFTDSIF QNCSTLVRLE TLILQKNELK DLFKVGLMTK NMPSLEILDV SWNSLEYHGP
DGNCPWVESL VVLNLSSNIL TDSVFRCLPP RIKVLDLHNN RIRSIPKDIT SLEALQVLNV
AFNSLADLPG CGAFNSLSIL IIDYNLISDP SADFFHSCQK IRSIKAGNNP FQCTCELREF
IQSIGQVSSD VVEGWPDSYK CEYPESYKGT PLKDFHLSQL SCNTALLVVT IVVPVLVLAV
TVSILCIYLD LPWYLRMVCQ WTQTRRRARN IPLEELQRTL QFHAFISYSE RDSAWVKNEL
VPCLEKEDIR ICLHERNFVP GKSIVENIIN CIEKSYKSIF VLSPNFVQSE WCHYELYFAH
HNLFHEGSDN LILILLEPIP QNNIPSKYHK LRALMTQRTY LEWPKEKSKR GLFWANIRAA
FNMKVALVIE NNDVKT
//
