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Database: UniProt
Entry: F6TVY8_HORSE
LinkDB: F6TVY8_HORSE
Original site: F6TVY8_HORSE 
ID   F6TVY8_HORSE            Unreviewed;       762 AA.
AC   F6TVY8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-MAY-2019, entry version 52.
DE   SubName: Full=Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha {ECO:0000313|Ensembl:ENSECAP00000013839};
GN   Name=HADHA {ECO:0000313|Ensembl:ENSECAP00000013839,
GN   ECO:0000313|VGNC:VGNC:50480};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013839, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000013839, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013839,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000013839}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013839};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
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DR   RefSeq; XP_001502833.1; XM_001502783.3.
DR   PaxDb; F6TVY8; -.
DR   PRIDE; F6TVY8; -.
DR   Ensembl; ENSECAT00000017079; ENSECAP00000013839; ENSECAG00000015725.
DR   GeneID; 100071381; -.
DR   KEGG; ecb:100071381; -.
DR   CTD; 3030; -.
DR   VGNC; VGNC:50480; HADHA.
DR   eggNOG; KOG1683; Eukaryota.
DR   eggNOG; COG1024; LUCA.
DR   eggNOG; COG1250; LUCA.
DR   GeneTree; ENSGT00940000154677; -.
DR   InParanoid; F6TVY8; -.
DR   KO; K07515; -.
DR   OMA; PFRYMDT; -.
DR   OrthoDB; 219667at2759; -.
DR   TreeFam; TF352288; -.
DR   Proteomes; UP000002281; Chromosome 15.
DR   Bgee; ENSECAG00000015725; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
DR   GO; GO:0016507; C:mitochondrial fatty acid beta-oxidation multienzyme complex; IBA:GO_Central.
DR   GO; GO:0042645; C:mitochondrial nucleoid; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IBA:GO_Central.
DR   GO; GO:0016509; F:long-chain-3-hydroxyacyl-CoA dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR   GO; GO:0032868; P:response to insulin; IEA:Ensembl.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR012803; Fa_ox_alpha_mit.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   TIGRFAMs; TIGR02441; fa_ox_alpha_mit; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN      363    540       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      543    638       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      675    752       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   762 AA;  82679 MW;  D5FE1DD359FF1DCC CRC64;
     MASRAIGSFR RFPASKTLRC PGYICRNFAG SSALLTRTHI NYGVKGDVAV VRINSPNSKV
     NTLNKELQSE FVEVMNEIWA SDQIRSAVLI SSKPGCFIAG ADINMLAACK TNQEVTQISQ
     EGQRIFEKLE KSPKPIVAAI SGSCLGGGLE LAISCQYRIA TKDKKTVLGS PEVLLGILPG
     AGGTQRLPKM VGVPAAFDMM LTGRNIHADR AKKMGLVDQL VEPLGPGLKP PEERTIEYLE
     EVAVTFAKGL ADKKISPKRD KGLVDKLTSV AMGIPFVRQQ IYKKVEEKVR KQTKGLYPAP
     LKIIDVVKTG IEQGSDAGYL SESQKFGELA MTKESKALIG LYHGQVLCKK NKFGAPQKEV
     KHLAILGAGL MGAGIAQVSV DKGLKTILKD ATLAGLGRGQ QQVFKGLNDK VKKKALTSFE
     RDSIFSNLTG QLDYQGFEKA DMVIEAVFED LSLKHRVLKE VEAVIPDHCV FASNTSALPI
     NEISAVSKRP EKVIGMHYFS PVDKMQLLEI ITTEKTSKDT TASAVAVGLK QGKVIIVVKD
     GPGFYTTRCL APMMSEVIRI LQEGVDPKKL DSLTTSFGFP VGAATLVDEV GVDVARHVAE
     DLGKAFGERF GGGSLDLLKQ MVSKGFLGRK SGKGFYIYQE GVKSKNLNSD MDSILASLKI
     PPKSEVSSDE DIQYRLVTRF VNEAVMCLQE GILATPAEGD IGAVFGLGFP PCLGGPFRFV
     DLYGAQKIVD RLRKYEAAYG KQFTPCQLLV DHANSPNKKF YQ
//
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