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Database: UniProt
Entry: F6TWL1_XENTR
LinkDB: F6TWL1_XENTR
Original site: F6TWL1_XENTR 
ID   F6TWL1_XENTR            Unreviewed;       765 AA.
AC   F6TWL1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUN-2019, entry version 54.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   Name=stat2 {ECO:0000313|Ensembl:ENSXETP00000047251,
GN   ECO:0000313|Xenbase:XB-GENE-985264};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000047251, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000047251}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000047251};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000047251}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
CC       Nucleus {ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|RuleBase:RU046415}.
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DR   EMBL; AAMC01034893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01034894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01034895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01034896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSXETT00000047251; ENSXETP00000047251; ENSXETG00000021830.
DR   Xenbase; XB-GENE-985264; stat2.
DR   eggNOG; KOG3667; Eukaryota.
DR   eggNOG; ENOG410XPN8; LUCA.
DR   GeneTree; ENSGT00950000182688; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000021830; Expressed in 14 organ(s), highest expression level in brain.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006952; P:defense response; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0043434; P:response to peptide hormone; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.10.532.10; -; 1.
DR   Gene3D; 2.60.40.630; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; PTHR11801; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   Pfam; PF02865; STAT_int; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF47655; SSF47655; 1.
DR   SUPFAM; SSF48092; SSF48092; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Activator {ECO:0000256|RuleBase:RU046415};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Cytoplasm {ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU046415};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription {ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN      571    666       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   COILED      140    167       {ECO:0000256|SAM:Coils}.
FT   COILED      188    215       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   765 AA;  88852 MW;  4EE16F5F1C89366B CRC64;
     MSQWAAILKL STEFQEKVMA LYSQELFPME VRQYLASWIE SQDWKQAARD LSLANVQLQN
     LLEHLDIQYS RFAQEQEILQ QRNFRRFKCD IQARYQAHPQ NLAEIIRDIL LYEKQILSEA
     REVQSQAGQP AQVSIVTGRQ QEIEKRVNEL AERVQSVDCE LKFLEDLQET FDFKYKNFEI
     MARSHPDDKH LKKKRDELQS LLNELDRKRK EVLDQIKGLL GLCETLVEFL QQELDEWLLK
     QKLECIGAPT ETSLKNLQGW VTKTAECFFQ LHRIFKNLAE LPSRISYEGD PLKIDPPNLI
     QRLNELLSLL LQRSFVVDRQ PIMAFPCKRP LVLKTSTQFS VRVRLLVNLP KLKDNLKVSF
     CVDKDSGKSR LYRKFNLLGT QNKAMEEIQG EGLVADFKHL ILKEQKAGTG GKGGKGANEA
     SSHVMEELHL ITFSMDFKYE DLKMKLETAT LPFIVISNIS QFVVAWASVL WFNLLSSDTK
     DVHFFSKPPM APWQSLKEAL SWQFSCTTRR ELDTDQLAML GKKLCEETPR DESTVSWNKF
     CKENLPRVSF TFWVWFDSVL ALVKAHLENI WNDGHVMGFV SRKKEEILLK AEISGTFLLR
     FSESICGGIT CTWVEQHEDG TYTIRSVQPY TKKELSSIPL TEIIRNYQLL AEENIPENPL
     KYRYPNIPKD EAFGPYYEKR PELTLQYEQY LQRKLIIVST RQVDELESNF SPRTSENNDM
     DEWNYTIDDD GLAGIAMNID SIMINADSDP MLSVSPVELY QELLV
//
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