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Database: UniProt
Entry: F6TXM8_HORSE
LinkDB: F6TXM8_HORSE
Original site: F6TXM8_HORSE 
ID   F6TXM8_HORSE            Unreviewed;       816 AA.
AC   F6TXM8;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 3.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
GN   Name=SLC26A4 {ECO:0000313|Ensembl:ENSECAP00000020752.3,
GN   ECO:0000313|VGNC:VGNC:23125};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020752.3, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000020752.3, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020752.3,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000020752.3}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020752.3};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   AlphaFoldDB; F6TXM8; -.
DR   STRING; 9796.ENSECAP00000020752; -.
DR   PaxDb; 9796-ENSECAP00000020752; -.
DR   Ensembl; ENSECAT00000024958.3; ENSECAP00000020752.3; ENSECAG00000022678.3.
DR   VGNC; VGNC:23125; SLC26A4.
DR   GeneTree; ENSGT01070000253775; -.
DR   HOGENOM; CLU_003182_9_4_1; -.
DR   InParanoid; F6TXM8; -.
DR   OMA; WKQNKTD; -.
DR   OrthoDB; 1067648at2759; -.
DR   TreeFam; TF313784; -.
DR   Proteomes; UP000002281; Chromosome 4.
DR   Bgee; ENSECAG00000022678; Expressed in adult mammalian kidney and 16 other cell types or tissues.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0031526; C:brush border membrane; IEA:Ensembl.
DR   GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR   GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR   GO; GO:0015111; F:iodide transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
DR   GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        120..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        149..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        223..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        255..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        296..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        332..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        381..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        421..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        516..547
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          571..765
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   816 AA;  89475 MW;  525D161E8CBEBB48 CRC64;
     MERAGRGQHS LSEQLRARRR LGSEARGRDL LHLPKVMAAP GARSEPPPLP EYSCSYVVSR
     PVYSELAFQQ QHERRPQERA TLRESLARGC SCSRKRTLGV LKTLLPILDW LPTYRIKEWL
     LSDIISGVST GLVGTLQGMA YALLAAVPVG YGLYSAFFPI LTYFIFGTSR HISVGPFPVV
     SLMVGSVVLS MAPDEHFLVS SSNGTALNTT VIDSAARDAA RVLIASSLTL LVGIIQLIFG
     GLQIGFIVRY LADPLVGGFT TAAAFQVLVS QLKIVLNVST KNYNGVLSII YTLIEIFQNI
     GSTNLADFIA GLLTIIICMA VKEVNDRFKH KIPVPIPIEV IVTIIATGIS YGVNLEKHYN
     AGIVKSIPRG FLPPVLPPVS LFSQMLAASF SIAVVAYAIA VSVGKVYAVK YDYTIDGNQE
     FVAFGISNIF SGFFSCFVAT TALSRTAVQE STGGKTQIAG IISAGIVMVA IVALGKLLEP
     LQKSVLAAVV IANLKGMFMQ VCDVPRLWRQ NKTDAVIWVF TCVASIILGL DLGLLAGLVF
     GLLTVVLRIQ FPSWSSLGII PTTDIYKSTK NYKNVEEPEG VKILRFSSPI FYGNVDGFKK
     CIKSTVGFDA IRVYNKRMKA LRKIRKLIQK GQLRATKNGI ISNAGSANSA FEPDEDIGDP
     EELDVPTKEI EIRVDWNSEL PVKVNVPKVP IHSLVLDCGA ISFLDVVGVR SLRVVVKEFQ
     RIDVNVYFAS LQDHVIEKLE KCGFFSDNIR KDIFFLTVHD AVLHLQNQVK SREGQDSILE
     MITLIQDCKD PLELMEAELI EEELDVQNEA MRRLAS
//
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