ID F6TZ28_HORSE Unreviewed; 1254 AA.
AC F6TZ28;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=RNF123 {ECO:0000313|Ensembl:ENSECAP00000020733.4,
GN ECO:0000313|VGNC:VGNC:22430};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020733.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020733.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020733.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020733.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020733.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR AlphaFoldDB; F6TZ28; -.
DR Ensembl; ENSECAT00000024935.4; ENSECAP00000020733.4; ENSECAG00000022815.4.
DR VGNC; VGNC:22430; RNF123.
DR GeneTree; ENSGT00940000155781; -.
DR TreeFam; TF313546; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000022815; Expressed in bone marrow and 23 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd16541; RING-HC_RNF123; 1.
DR CDD; cd12882; SPRY_RNF123; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR045129; RNF123/RSPRY1-like.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035773; SPRY_RNF123.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13363:SF5; E3 UBIQUITIN-PROTEIN LIGASE RNF123; 1.
DR PANTHER; PTHR13363; RING FINGER AND SRY DOMAIN-CONTAINING; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 74..254
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1194..1232
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 1254 AA; 140974 MW; 189FFA12680018BA CRC64;
MASKGAGVSF SRKSYRLTSD AEKSKVTGIV QEKLLNDYLH RIFSSRDHTP TTATNRKSLN
FQNLPEHLDQ LLHVDIEDEE SQGQIEGRLG PSTVVLDHTG GFEGLLLVND DLLGVIGHSN
FGTIRSTTCV YKGKWVYEVL ISSQGLMQIG WCTINCRFNQ EEGVGDTHNS YAYDGNRVRK
WNVTTTNYGK AWAAGDIVSC LIDLDDGTLS FCLNGVSLGT AFENLSRGLG MAYFPAISLS
FKESVAFNFG SRPLRYPVTG YRPLQDPPRA DLVRAQKLLG CFQAVLGVEL DPVEGRLVEK
ESSQWQLQGQ PTVLLTLAHI FHHFAPLLRK VYVVEAVLMS FLLGIMEVGT PAQAQSVVRQ
VLDLLWLFME DYEVQDCLKQ LMMSLLRLYR FSPIVPDLGL QGRESKEVKD ETAEERLRRR
AYERGCQRLK KRIEVVEELQ VQILKLLLNN KDENGGEASR YIFLTKFRKF LQENASGRGN
MPMLCPPEYM VCFLHRLISA LRYYWDEYKA SNPSASFSEE AYIPPQVFYN GKVDYFDLQR
LGGLLSHLRK TLKDDLASKA NILIDPLELQ AATMDDLDED EEPASAAAAA AAQRPMQALA
MGGALPLPRP GWLSSPTLGR ANRFLSTAAV SLMTPRRPLS TSEKVKVRTL SAEQRTREDI
EGSHWNEGLL LGRPPEEPEQ PLTENSLLEV LDGAVIMYNL SVHQQLGKMV GVSDDVNEYA
MALRDTEDKL RRCPKWRKDI LAELTKSQKV FSEKLDHLSR RLAWVHATVY SQEKMLDIYW
LLRVCLRTIE HGDRTGSLFA FMPEFYLSVA INSYSALKNY FGPVHSMEEL PGYEETLTRL
AAILAKHFAD TRIVGTDIRD SLMQALASYV CYPHSLRAVE RIPEEQRIAM VRSLLAPYEQ
RPWAQTNWIL VRLWRGCGFG YRYTRLPHLL KTKPEDANLP SLQKPCPSTL LQQHMADLLR
QGPDVAPSFL NSVLNQLNWA FSEFIGMIQE IQQAAERLER NFVDSRQLKV CATCFDLSVS
LLRVLEMTIT LVPEIFLDWA RPTSEMLLQR LAQLLNQVLN RVTAERNLFD RVVSLRLPGL
ESVDHYPILV AVTGILVQLL VHGPASGKER ATSVLLADPC FQLRSICYLL GQPEPSAPGT
ALPAPDRKHF SLQSYTDYIS VEELAQVEQM LAHLTSASAQ AAAASLPTSE EDLCPICYAH
PISAVFQPCG HKSCKACINQ HLMNNKDCFF CKATIESVED WDKAANASAT SSTT
//
