ID F6U3M2_ORNAN Unreviewed; 2695 AA.
AC F6U3M2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=ITPR1 {ECO:0000313|Ensembl:ENSOANP00000020317.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000020317.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000020317.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000020317.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000020317.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000020317.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9258.ENSOANP00000020317; -.
DR Ensembl; ENSOANT00000020320.4; ENSOANP00000020317.3; ENSOANG00000003765.4.
DR eggNOG; KOG3533; Eukaryota.
DR GeneTree; ENSGT00940000155071; -.
DR HOGENOM; CLU_432518_0_0_1; -.
DR Proteomes; UP000002279; Chromosome X1.
DR Bgee; ENSOANG00000003765; Expressed in cerebellum and 7 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF2; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2219..2241
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2253..2271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2277..2303
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2340..2365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2385..2407
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2516..2539
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 112..166
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 231..287
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 294..358
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 364..420
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 991..1011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1700..1731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1824..1851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1873..1897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2666..2695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1008
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1826..1851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2695 AA; 307119 MW; 726E246E0EE5AB69 CRC64;
MSDKMSSFLH IGDICSLYAE GSTNGFISTL GLVDDRCVVQ PEAGDLNNPP KKFRDCLFKL
CPMNRYSAQK QFWKAAKPGA NSTTDAVLLN KLHHAADLEK KQNETENRKL LGTVIQYGNV
IQLLHLKSNK YLTVNKRLPA LLEKNAMRVT LDEAGNEGSW FYIQPFYKLR SIGDSVVIGD
KVVLNPVNAG QPLHASSHQL VDNPGCNEVN SVNCNTSWKI VLFMKWSDNK DDILKGGDVV
RLFHAEQEKF LTCDEHRKKQ HVFLRTTGRQ SATSATSSKA LWEVEVVQHD PCRGGAGYWN
SLFRFKHLAT GHYLAAEMDS DQDASRSRLR NAQEKMVYSL VSVPEGNDIS SIFELDPTTL
RGGDSLVPRN SYVRLRHLCT NTWVHSTNIP IDKEEEKPVM LKIGTSPVKE DKEAFAIVPV
SPAEVRDLDF ANDASKVLGS IAGKLEKGTI TQNERRSVTK LLEDLVYFVT GGTNSGQDVL
EVVFSKPNRE RQKLMREQNI LKQIFKLLQA PFTDCGDGPM LRLEELGDQR HAPFRHICRL
CYRVLRHSQQ DYRKNQEYIA KQFGFMQKQI GYDVLAEDTI TALLHNNRKL LEKHITAAEI
DTFVSLVRKN REPRFLDYLS DLCVSMNKSI PVTQELICKA VLNPTNADIL IETKLVLSRF
EFEGVSTGEN HLEVGEDEEE VWLFWRDSNK EIRSKSVREL AQDAKEGQKE DRDVLSYYRY
QLNLFARMCL DRQYLAINEI SGQLDVDLIL RCMSDENLPY DLRASFCRLM LHMHVDRDPQ
EQVTPVKYAR LWSEIPSEIA IDDYDSSGTS KDEIKERFAQ TMEFVEEYLR DVVCQRFPFS
DKEKNKLTFE VVNLARNLIY FGFYNFCDLL RLTKILLAIL DCVHVTTIFP ISKMAKGEEN
KGSNVMRSIH GVGELMTQVV LRGGGFLPMA PLAAAPEGNV KQAEPEKEDI MVMDTKLKII
EILQFILNVR LDYRISCLLC IFKREFDESN AQTSEPSSGS SSQEGPSNVP GALDFEHIEE
QAEGIFGGSE ENTPLDLDDH GGRTFLRVLL HLTMHDYPPL VSGALQLLFR HFSQRQEVLQ
AFKQVQLLVT SQDVDNYKQI KQDLDQLRSI VEKSELWVYK GQGPDETMDG ASGENEHKKT
EEGHSKSRKH ESTSSYNYRV VKEILIRLSK LCVQENASVR KSRKQQQRLL RNMGAHTVVL
ELLQIPYEKA EDTRMQEIMK LAHEFLQNFC AGNQQNQALL HKHINLFLNP GILEAVTMQH
IFMNNFQLCS EINERVVQHF VHCIETHGRN VQYIKFLQTI VKAEGKFIKK CQDMVMAELV
NSGEDVLVFY NDRASFQTLI QMMRSERDRM DENSPLMYHI HLVELLAVCT EGKNVYTEIK
CNSLLPLDDI VRVVTHEDCI PEVKIAYINF LNHCYVDTEV EMKEIYTSNH MWKLFENFLI
DICRACNNTS DRKHADSILE KYVTEIVMSI VTTFFSSPFS DQSTTLQTRQ PVFVQLLQGV
FRVYHCNWLM PSQKASVESC IRVLSDVAKS RAIAIPVDLD SQVNNLFLKS HNIVQKTAMN
WRLSARNAAR RDSVLAASRD YRNIIERLQD IVSALEDRLR PLVQAELSVL VDVLHRPELL
FPENTDARRK CESGGFICKL IKHTKQLLEE NEEKLCIKVL QTLREMMTKD RGYGEKGEAL
RQILVNRYYG NIRPAGRRES LTSFGNGPLS PGGPSKAGGG GGSSGSSTMS RGEMSLADVQ
CHLDKEGASN LVIDLIMNAS SDRVFHESIL LAIALLEGGN TTIQHSFFCR LTEDKKSEKF
FKVFYDRMKV AQQEIKATVT VNTSDLGNKK KDDDSEKDAP ARKRVKEPTT QITEEVRDQL
LEATTATRKA YTTYRREADP DDHYPSGEGA QATTDKGKDD LEMSAVITIM QPILRFLQLL
CENHNRDLQN FLRCQNNKTN YNLVCETLQF LDCICGSTTG GLGLLGLYIN EKNVALINQT
LESLTEYCQG PCHENQNCIA THESNGIDII TALILNDINP LGKKRMDLVL ELKNNASKLL
LAIMESRHDS ENAERILYNM RPKELVEVIK KAYMQGEVEF EDGENGEDVA ASPRNVGHNI
YILAHQLARH NKELQNMLKP GGQVEGDEAL EFYAKHTAQI EIVRLDRTME QIVFPVPSIC
EFLTKESKLR IYYTTERDEQ GSKINDFFLR SEDLFNEMNW QKKLRAQPVL YWCSRNMSFW
SSISFNLAVL MNLLVAFFYP FKGVRGGTLE PHLSGLLWTA MLISLAIVIA LPKPHGIRAL
IASTILRLIF SVGLQPTLFL LGAFNVCNKI IFLMSFVGNC GTFTRGYRAM ILDVEFLYHL
LYLLICAMGL FVHEFFYSLL LFDLVYREET LLNVIKSVTR NGRSIILTAV LALILVYLFS
IVGYLFFKDD FILEVDKLPN DTAFPDTGES MASEFLYSDV CRLGHGENCS SPIPTKELIS
GEEIEEEDKE HTCETLLMCI VTVLSHGLRS GGGVGDVLRK PSKEEPLFAA RVIYDLLFFF
MVIIIVLNLI FGVIIDTFAD LRSEKQKKEE ILKTTCFICG LERDKFDNKT VTFEEHIKEE
HNMWHYLCFI VLVKVKDSTE YTGPESYVAE MIKERNLDWF PRMRAMSLVS SDSEGEQNEL
RNLQEKLEST MKLVTNLSGQ LSELKDQMTE QRKQKQRIGL LGHPPHMNVN PQQPA
//
