ID F6U870_XENTR Unreviewed; 345 AA.
AC F6U870;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=RNA binding protein fox-1 homolog {ECO:0000256|PIRNR:PIRNR037932};
GN Name=rbfox3 {ECO:0000313|Ensembl:ENSXETP00000043661};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000043661};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000043661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000043661};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000043661}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- FUNCTION: RNA-binding protein that regulates alternative splicing
CC events. {ECO:0000256|PIRNR:PIRNR037932}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR037932}.
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DR AlphaFoldDB; F6U870; -.
DR Ensembl; ENSXETT00000043661; ENSXETP00000043661; ENSXETG00000020236.
DR AGR; Xenbase:XB-GENE-976381; -.
DR Xenbase; XB-GENE-976381; rbfox3.
DR eggNOG; KOG0125; Eukaryota.
DR HOGENOM; CLU_048440_0_0_1; -.
DR OrthoDB; 5406502at2759; -.
DR TreeFam; TF315942; -.
DR Bgee; ENSXETG00000020236; Expressed in brain and 11 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12407; RRM_FOX1_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR025670; Fox-1_C_dom.
DR InterPro; IPR034237; FOX1_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR017325; RBFOX1-3.
DR InterPro; IPR047131; RBFOX1-like.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR15597; ATAXIN 2-BINDING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR15597:SF25; RNA BINDING PROTEIN FOX-1 HOMOLOG 3; 1.
DR Pfam; PF12414; Fox-1_C; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037932; Ataxin_2_bd_A2BP; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR037932};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|PIRNR:PIRNR037932}; Nucleus {ECO:0000256|PIRNR:PIRNR037932};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR037932, ECO:0000256|PIRSR:PIRSR037932-
KW 1}.
FT DOMAIN 133..209
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 23..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 107..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 134
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 142
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 143
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 167
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 172
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 176
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 200
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 210
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
SQ SEQUENCE 345 AA; 37717 MW; F249DC2C4EFBB22E CRC64;
MKQMVIIKLS TTWDTLNFFP GPKLGNQDTS APPEAMAQPY STTQYPQPPQ NGLPAEYATQ
HPLPTPDYSG QTTVSEHALT LYTAGHSHGE PQGNEVSTQS VTGTQTLTTD EVSQTDSSQQ
LQCPESTEKQ QPKRLHVSNI PFRFRDPDLR QMFGQFGKIL DVEIIFNERG SKGFGFVTFE
TSMDADRARE KLNGTIVEGR KIEVNNATAR VMTNKKPVNP YTNGWKLNPV VGAVYGPEFY
AVTGFPYPPA GATIAYRGAQ LRGRGRAVYN TFRAAPPPPP IPTYGAVVYQ DGFYGAEIYG
GYAAYRYAQP AAAAAYSDSY GRVYAAADPY HHTIGPAATY SIGTM
//
