ID F6U8B1_HORSE Unreviewed; 820 AA.
AC F6U8B1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Scavenger receptor class F member 1 {ECO:0000313|Ensembl:ENSECAP00000018186.4};
GN Name=SCARF1 {ECO:0000313|Ensembl:ENSECAP00000018186.4,
GN ECO:0000313|VGNC:VGNC:110544};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018186.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018186.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018186.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018186.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018186.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; F6U8B1; -.
DR STRING; 9796.ENSECAP00000018186; -.
DR PaxDb; 9796-ENSECAP00000018186; -.
DR Ensembl; ENSECAT00000022029.4; ENSECAP00000018186.4; ENSECAG00000020764.4.
DR VGNC; VGNC:110544; SCARF1.
DR GeneTree; ENSGT00950000183101; -.
DR HOGENOM; CLU_054892_0_0_1; -.
DR InParanoid; F6U8B1; -.
DR OMA; CFHGNCH; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000020764; Expressed in synovial membrane of synovial joint and 17 other cell types or tissues.
DR GO; GO:0030169; F:low-density lipoprotein particle binding; IBA:GO_Central.
DR GO; GO:0005044; F:scavenger receptor activity; IBA:GO_Central.
DR GO; GO:0016358; P:dendrite development; IBA:GO_Central.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR GO; GO:0016322; P:neuron remodeling; IBA:GO_Central.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IBA:GO_Central.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 3.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR PANTHER; PTHR24043:SF0; SCAVENGER RECEPTOR CLASS F MEMBER 1; 1.
DR Pfam; PF00053; Laminin_EGF; 2.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00180; EGF_Lam; 4.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS50026; EGF_3; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 43..77
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 205..239
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 67..76
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 229..238
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 820 AA; 86389 MW; 953DDE44D8D38220 CRC64;
PAARDSDPPA EPGCPPADPS LPHSSSAKFQ CCPGWRQKDQ ECTIPICEGQ DACREDEVCV
KPGLCRCKPG FFGAQCNSRC PGQYWGPDCR ESCACHPHGQ CEPATGVCHC QADRWGDRCE
FACTCGPHGR CDPVTGACRC EPGWWSPTCR RPCQCNPAAA RCDQATGSCL CEPGWWGRRC
SFRCTCHGSP CAQETGRCAC RPGWWGPDCR HRCECARGRC SAASGQCSCP PGFRGARCEL
RCPAGSYGAQ CRHSCGHCKQ NEPCSADTGS CESCEPGWNG TQCHQPCSPG TFGESCRQQC
PHCRLGEACQ PDTGHCQRCD PGWLGPRCED PCPNGTFGEG CGSTCPTCDQ GACDAVTGEC
VCNAGYWGPS CNTSCPSGFH GNNCSIPCEC SEGPCHPVSG ACQLGSRSQD AALIAGILVP
LLLLLLGLAC CACCCWAARL DPKDRPVRDG AAVSRMKLQV WGALTSLGSA LPCGSLSSHK
LPWVTVSHHD PETPFNHSFI EPPSAGWASD DSFSSDPESG EEDEGPAYCV PPQEGMVPVA
QAEPSEVSLA GGPFPPPEDA STPFAIPRTS SLARAKRPSV SFAEGTKFAP QSRRSSGELS
SPLRKPKRLS RGAQPGPEGQ EAEEPTGPEQ AEMDKALPGA ASPRDSTTGR RRLPLGGRTV
AERVEAIEGS VQESSDSVTT IYMLAGTPRG SEGPVRSVLR RFGSFQKGQA EPKVKSAIPK
PPRRALSRNK GSPGPASSSA NQSPGSAPKE ELKGTLESVG AGPEEVGRDL GDGIKNSGRA
QEPGPEGGPP EQDPQKLAEG EGQEEPQYEN VVTISGPPEP
//
