ID F6UAH0_XENTR Unreviewed; 592 AA.
AC F6UAH0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Hyaluronan synthase 1 {ECO:0000313|Ensembl:ENSXETP00000008836, ECO:0000313|RefSeq:XP_031762651.1};
GN Name=has1l {ECO:0000313|RefSeq:XP_031762651.1,
GN ECO:0000313|Xenbase:XB-GENE-22062960};
GN Synonyms=has1 {ECO:0000313|Ensembl:ENSXETP00000008836};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000008836};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000008836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000008836};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000008836}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031762651.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031762651.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031762651.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NodC/HAS family.
CC {ECO:0000256|ARBA:ARBA00006782}.
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DR RefSeq; XP_031762651.1; XM_031906791.1.
DR Ensembl; ENSXETT00000008836; ENSXETP00000008836; ENSXETG00000004083.
DR KEGG; xtr:100491673; -.
DR AGR; Xenbase:XB-GENE-961588; -.
DR Xenbase; XB-GENE-961588; has1.
DR Xenbase; XB-GENE-22062960; has1l.
DR eggNOG; KOG2571; Eukaryota.
DR HOGENOM; CLU_029695_3_0_1; -.
DR OMA; CILRRDM; -.
DR TreeFam; TF332506; -.
DR Reactome; R-XTR-2142850; Hyaluronan biosynthesis and export.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000004083; Expressed in egg cell and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR22913; HYALURONAN SYNTHASE; 1.
DR PANTHER; PTHR22913:SF4; HYALURONAN SYNTHASE 1; 1.
DR Pfam; PF13641; Glyco_tranf_2_3; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..540
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 552..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 160..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 68748 MW; 21D7F3AB012B37AB CRC64;
MKEEQLWLGV VRRILTFGFA CLVLTGVTWA FADSIPLVTD EFRILAFGIY GAFLSVHLVI
QSLFAFLEHR KMKRDDNICT YTKMVALTIS AFQEDPVYLR ECLESVKNTH YPPDKLKVIM
VIDGNSPEDQ YMMDMFKEVF AGEDIGTICW QNNYHSWKPE NAAKSPETAQ QDENDTIARS
QQEQSDDLPE TTIDADYEIE VEDPELGEVE HLIKSKRCVC IMQKWGGKRE VMYTAFKALG
ESVDYVQVCD SDTKLDPLAT LELVKVLESN DRYGAVGGDV RILNLEESYI SFMSSLRYWI
AFNVERACQS YFDCVSCISG PLGLYRNDLL QTFLESWYNQ KFLGTHCTFG DDRHLTNRML
SIGYATKYTA RSKCFSETPA QFLRWLNQQT RWTKSYFREW LYNSLWWHKH HLWMTYESVI
AGIFPFFVTA TVVRLFFSCH LWDIVWVLIC VQLIATVKAL YACLLRGNPI MIFMSLYAIL
YMGGLLPSKY FALITMNKSS WGTSGRKKIV GNYIPLLPLS IWGAILFTGI LYTIVMMSLC
TSCRLIEAEK RYLIYGSAFY LGYWALMFLL YWLWVKRTCR RRTDDYDLQG YT
//
