ID F6UB35_XENTR Unreviewed; 1361 AA.
AC F6UB35;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=GTPase-activating protein and VPS9 domains 1 {ECO:0000313|Ensembl:ENSXETP00000012072};
GN Name=gapvd1 {ECO:0000313|Ensembl:ENSXETP00000012072};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000012072};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000012072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000012072};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000012072}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
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DR PaxDb; 8364-ENSXETP00000061766; -.
DR Ensembl; ENSXETT00000012072; ENSXETP00000012072; ENSXETG00000005493.
DR AGR; Xenbase:XB-GENE-997388; -.
DR Xenbase; XB-GENE-997388; gapvd1.
DR eggNOG; KOG2319; Eukaryota.
DR HOGENOM; CLU_002165_1_0_1; -.
DR TreeFam; TF105908; -.
DR Bgee; ENSXETG00000005493; Expressed in 4-cell stage embryo and 14 other cell types or tissues.
DR ExpressionAtlas; F6UB35; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd05129; RasGAP_RAP6; 1.
DR Gene3D; 1.10.246.120; -; 1.
DR InterPro; IPR041545; DUF5601.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR Pfam; PF18151; DUF5601; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
FT DOMAIN 144..353
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 444..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1043..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1361 AA; 151678 MW; 3A6F91B846A5C0D7 CRC64;
MVKPDIHTLA RHLKQERLYV NSEKQLIQRL NADVLKTAER LYRTSWIAKQ QRINLDRLIL
TSAEASPAEC CQHAKVLEDT QFVDGYKQLG FQETAYGEFL NRLRENPRLI ASCLVAGEKL
NHENAQSVIH TVFTSLYGNC IMQEDESYLL QVLRYLIEFE LKESDNPQRL LRRGTCAFSI
IFKLFSEGLF SAKLFLTATL HEPIMQLLVE DEDHLETDPS KLIERFSPAQ QEKLFGEKGS
EAFRQRVQEM VESNEAKLVT LVNKFIGYLK QNTYCFPHSL RWIVSQMFKT LSCVEGLEVS
EVRSMCTDLL LTCFICPAIV NPEQYGIISD APINEVARFN LMQVGRLLQQ LALTGFEEGD
SRNKNNLSKF DKSCVAAFLD VVIGGRAVET PPLSSVNLLE GLSRTVVYMT YSQLMSLLGF
LRTVISSDQL REEDRMALEN LLATVPQTKP GKSNNDTTPY STPQLSPATT PACKKNRLPI
VTRSRSKTSL MEAENEGSPQ EVTPGQPEEV LVISLGTGPQ LTPGMMSENE VLNMQLVDGG
QVDVPVDESK LHGKPDKTLR FSLCSDNLEG ISEEEENPCS TGPSNRSNSV SSLDLEGESV
SELGGGPSGS NGVEALQLLE HEQATTQDNL DDKLRKFEIR DMMGLTDDRD ISETVSETWS
TDVLGSDFDP NIDEDRLQEI AGAAAENMLG SLLCLPGSGS ILLDPCTGST ISETTSEAWS
VEVLPSDSAP DLKQEERLQE LESCSGLGST SDDTEVREVS SRPSTPGLSV VSGISATSED
IPNKIEDLRS ECSSDFGGKD SVTSPEAEES VHGPHHITAP PTQTESLLAM FDPLAPASNE
VVRPKVHYAR PSHPPPDPPV LEGASGGNEA RLPMFGSHVF VPMESEAYRQ RHSCPERLVR
SRSSDIASSI RRPMSDPGWV RRGVNEDREL PTGTAINALI NPPQASSSSP SKDSSRGEPE
EKKDSDDERS DRNKPWWKKR FVSAMPKAPI PFRKKEKHEK EREDLVQDRF SVADDSTSQL
GPHSQAAEDI LAKYRNAIKR TIPNEGSSVP YEGADAVGDG ESLHDSPRDE ALQNMASDDL
LDSASQVAHP QEPAFSYRDA KKKLRLALCS ADSVAFPVLS HSTRNGLPDH TDPEDNEIVC
FLKVQLAEAI NLQDKNLMAQ IQETMRCVSR FDSRSCSKIL ASIAEDYRKR ASYIAYLTRC
RQGLQTTQAH LERLLQRVLR DKEVSTRYFT TVCVRLLLES KEKEIHEFIQ DFQKLTAADD
KTAQVEEFLQ SLYGAMAQDV IWQNASEEQL QDAQIAIERS IMNRIFKLAF YPNQDADILR
DQVLHEHIKR LSKVVTANHR ALQIPEVIKP FLKLWDSSEP Q
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