ID F6UDJ8_ORNAN Unreviewed; 732 AA.
AC F6UDJ8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
GN Name=MTMR12 {ECO:0000313|Ensembl:ENSOANP00000017321.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000017321.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000017321.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017321.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000017321.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017321.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004369}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR AlphaFoldDB; F6UDJ8; -.
DR STRING; 9258.ENSOANP00000017321; -.
DR Ensembl; ENSOANT00000017324.3; ENSOANP00000017321.3; ENSOANG00000010931.4.
DR eggNOG; KOG1089; Eukaryota.
DR GeneTree; ENSGT00940000160263; -.
DR HOGENOM; CLU_021912_2_0_1; -.
DR InParanoid; F6UDJ8; -.
DR OMA; LRFQGHG; -.
DR TreeFam; TF315197; -.
DR Proteomes; UP000002279; Chromosome 3.
DR Bgee; ENSOANG00000010931; Expressed in ovary and 8 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:UniProtKB-SubCell.
DR CDD; cd14594; PTP-MTMR12; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR030576; MTMR12_PTP.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 223..660
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
SQ SEQUENCE 732 AA; 83488 MW; EF6F9C706F28B0E0 CRC64;
MLAKGGGGGG AGAGAGAGGG GGGTGLGLGG GRGPKPSFVS YVRPEEMHTN EKETAEKEVN
LRLLPGEQVL CEANMVLKVI QEDSCQRGIC GRLICTDFKI AFLGDESASE DNELQFKNKV
LGENDITLHC VDQIYGVFDE KKKSLLGHLK KYPEKLIIHC KDLRVFHFCL RYTKEEEVKR
IVSGIIHHTQ APKLLKRLFL FSYATAATSN KVVIEKRNKT VMFDTIKDWR QELERTRGNM
KYKAVSANED YKICEKFPAY FVVPISLPEE DISRFQGKGI PIWCWSCHNS CALLKMSAFP
REPDESTLQI QKAFLDGIYK TIHKPPYETV KTEDLSNSLS LQEIQTAYSK FKQLFLIDNS
SEFWDTDVKW FSLLENSNWL DIIRRCLKKA VEIAEYLEGQ NVNILLLEEN ASDLCCIISS
LVQVMMDPYC RTKLGFQSLI QKEWVMGAHS FLDRCNHLRQ NEKEEVPVFL LFLDCVWQLV
QQYPPAFEFT ETYLTVLSDS MYIPIFSTFF FNSPCQKDSN LAGESQDAQS RPLSLLSVWD
WSVQFEPKAL SLLNNPLYVE KPKLEKSQKK ATPFKHQRQL SFPLTQTKSS PKKGFFREET
DHFIKNILGK RISKLINSSD EVPNNFREFY DSWHSKPIDY HGLLLPHLEG PEIKVWAQRY
LRWIPEAQIL GGGMVATVAK VLEMMEEVQS LQKKIDEKHN SQKASQTDVV SLLKKSTRLS
SLFPLLYSRD IP
//
