ID F6UFJ3_XENTR Unreviewed; 1226 AA.
AC F6UFJ3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Ubiquitin carboxyl-terminal hydrolase 40 {ECO:0000313|RefSeq:XP_002932051.3, ECO:0000313|RefSeq:XP_012826680.2};
DE SubName: Full=Ubiquitin specific peptidase 40 {ECO:0000313|Ensembl:ENSXETP00000010577};
GN Name=usp40 {ECO:0000313|Ensembl:ENSXETP00000010577,
GN ECO:0000313|RefSeq:XP_002932051.3, ECO:0000313|RefSeq:XP_012826680.2,
GN ECO:0000313|RefSeq:XP_012826681.2,
GN ECO:0000313|Xenbase:XB-GENE-980927};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000010577};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000010577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000010577};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000010577}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002932051.3, ECO:0000313|RefSeq:XP_012826680.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002932051.3,
RC ECO:0000313|RefSeq:XP_012826680.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002932051.3,
RC ECO:0000313|RefSeq:XP_012826680.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002932051.3; XM_002932005.5.
DR RefSeq; XP_012826680.2; XM_012971226.3.
DR RefSeq; XP_012826681.2; XM_012971227.3.
DR STRING; 8364.ENSXETP00000010577; -.
DR PaxDb; 8364-ENSXETP00000005460; -.
DR Ensembl; ENSXETT00000010577; ENSXETP00000010577; ENSXETG00000004875.
DR KEGG; xtr:100486255; -.
DR AGR; Xenbase:XB-GENE-980927; -.
DR Xenbase; XB-GENE-980927; usp40.
DR eggNOG; KOG1863; Eukaryota.
DR HOGENOM; CLU_009719_0_0_1; -.
DR OMA; PEGSHWF; -.
DR TreeFam; TF106281; -.
DR Proteomes; UP000008143; Chromosome 9.
DR Bgee; ENSXETG00000004875; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF842; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 40; 1.
DR Pfam; PF00443; UCH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|RefSeq:XP_002932051.3,
KW ECO:0000313|RefSeq:XP_012826680.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 43..477
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 14..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1226 AA; 137292 MW; 6812CA011514A520 CRC64;
MFGDLFEEDE DFSFLLSSPN KNGKKSHPRD SKTPEPRGDT RLSGLRNQGG TCYLNSLLQT
LFFTPEFREA LFALGPKELG SLEEKDTPDS RVRIIPLQLQ RLFAQLLLLD QQALSTTDLT
ESFGWNSSEE TSQHDVQELN RILFSALESS LEGTSGHDLI KRLYHGTIVN CIQCKECGYI
SERQEDFLDL TVAVKGVGSL ENSLCSMYLE EEHFDGDNLY RCGSCAKLVP ATKSAKLGKL
PPFLTLSLLR FNFDFVKCER YKETSRYTFP TRLIIRPFCE QHNLEDSVYA YELFSVIIHK
GGCYGGHYHA YIQDVDELGH WGLKEVAKKT ASAQESESKQ DCPIVALASI IAEAGADQMV
AVDQLGQKLL EYMGTSWNKT YRKQHGAMHK FLQSHPSVFQ MSADGSLVGL AHSVPDTVGS
DSESSRPGTP EKSQAPSRSA GHWFDFNDSK VEPIRETDIE KQFQGKESAY MLFYRKCEMN
RPPEAKGNPR FGVPEHILND MDQENIELQT KRTESALQIN CMDLCLHLSS HYQYENGALH
PAHPRNNSKL AIAIDRRRTV EDLKQLAFQV LDESLEGQVL SIARVLPAGL HIFQNLIDAK
MDLVTAGITD GTDIFVWDGK QVGGVMIQSG AEFTPVLLTI LRPVLQTNSS AEFSESQRAF
PSCACLKDIQ KELAGPTCEE SVLCFPSSEN SEQWSFYSAD DSNKSLKELG LRDGSSILLF
DTRSDGDVYL ASERHLSKDA KQNFLMVQDW CRQQDEKETV KIIITPNTTI QDIHVKAVEL
LQLQEECSKN DTCLRPLHRK EKLLPPVPES LTVQEAELKN GCTLGLCKGK APSPSQIFLY
FISGTDLQEG SEQEIILEET LTVRQSLERM LNKAGLPGKA GWHLRKMDWC YEAGEALSDE
ESTLKELNIC AGDTLVITEG KLPPKGFLKL SIWLYCPHTQ QDAMNHVTCE PGALQTSTTE
DNNMQEGGTS NFCSVGEIEI SGDLSLQDVK MQILTLPVFE ALGIPSPEFL RVWTLENKHL
GKILRSPPVL LSEYKLGSKP ALCIEPLQVE ECLGAKDLVL RVQLSVPGER RYFPPVDIVW
DISRGCTAPA LLHRIAMHCS LPTDKVEIAK HFPEKYEWLP ISSWTQHVSR KRKKKKLESL
QGAPYHLKDG DIIGVKNLLL DDWTDFSSEI DRIGKEKQQQ QQRPANGNKS LHAEGLQNNT
AGSNGRAKSK ARKAETSLSI RVGVFR
//
