ID F6UGP7_HORSE Unreviewed; 794 AA.
AC F6UGP7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Protocadherin beta 14 {ECO:0000313|Ensembl:ENSECAP00000001009.2};
GN Name=PCDHB14 {ECO:0000313|Ensembl:ENSECAP00000001009.2};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000001009.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000001009.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000001009.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000001009.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000001009.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6UGP7; -.
DR STRING; 9796.ENSECAP00000001009; -.
DR PaxDb; 9796-ENSECAP00000001009; -.
DR Ensembl; ENSECAT00000001301.3; ENSECAP00000001009.2; ENSECAG00000031230.2.
DR GeneTree; ENSGT00940000163362; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; F6UGP7; -.
DR OMA; IFRAELW; -.
DR OrthoDB; 5402790at2759; -.
DR TreeFam; TF332299; -.
DR Proteomes; UP000002281; Chromosome 14.
DR Bgee; ENSECAG00000001422; Expressed in articular cartilage of joint and 16 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF81; PROTOCADHERIN BETA-14; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..794
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040426932"
FT TRANSMEM 688..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..133
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 134..242
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 243..347
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 348..451
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 452..561
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 576..671
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 794 AA; 86858 MW; 63FB1E9970F29AFB CRC64;
MAIRGALALR KRQVLILFVL LGLSQAGPES VRYSVAEETE IGSFVGNLAR DLGLGVEELS
SREARVVSDD NKKHLHLDLP TGDLLLNEKL DREELCSSTE PCVLHFQVVL ENPLQFFRAE
LHVKDINDHS PTFLDKEILI QISESTTIGT TFLMESAQDL DIGRNSLQNY TVSPNSHFYI
KIRDSSDGKI YPELVLDREL DHEHEPELRL TLTALDGGSP PRSGKTLVLI KVLDVNDNAP
EFPQRLYEVQ VLEDTPIGSW IITISAKDLD AGNYGKISYT FLHASEDIRK TFEINPASGD
VHLRSSLDFE VTQSYTINIQ ATDGGGLSEE CTLLIKVIDI NDNPPEVTMS SITKIIPENA
SETLVALFSV RDKDSGDNGR MVCSIQDDLP FSLKPTFKNF FTLVSEKALD REMRAEYNIT
ITVADMGSPR LKTQHTITVL VSDVNDNAPA FTQTSYTLWV RENNSPALHI GSVSATDRDA
GANAQLTYSL LPPQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFG VGATDRGSPA
LSSQARVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA EAGYLVTKVV AVDGDSGQNA
WLSYRLLKAT EPGLFGVWPH NGEVRTARLL SERDAPKHRL LVQVRDNGEP PRSASVTLHV
LLVDGFSQPY LPLPEAAAEQ ARADPLTVYL VVALASVSSL FLLSVLLFVA VRLCRRSRAA
SLGGCSVPEG PFPGHLVDVS GTGTLSQSYQ YEVCLRAGSG TSEFKFLKSL ACDHQGSVND
VEENSNFVNG FGFN
//
