ID F6UH76_MONDO Unreviewed; 503 AA.
AC F6UH76;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=aromatase {ECO:0000256|ARBA:ARBA00038885};
DE EC=1.14.14.14 {ECO:0000256|ARBA:ARBA00038885};
DE AltName: Full=Cytochrome P-450AROM {ECO:0000256|ARBA:ARBA00043174};
DE AltName: Full=Estrogen synthase {ECO:0000256|ARBA:ARBA00042499};
GN Name=CYP19A1 {ECO:0000313|Ensembl:ENSMODP00000002559.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000002559.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000002559.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000002559.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR RefSeq; XP_016284103.1; XM_016428617.1.
DR AlphaFoldDB; F6UH76; -.
DR STRING; 13616.ENSMODP00000002559; -.
DR Ensembl; ENSMODT00000002613.4; ENSMODP00000002559.3; ENSMODG00000002101.4.
DR GeneID; 100031295; -.
DR KEGG; mdo:100031295; -.
DR eggNOG; KOG0157; Eukaryota.
DR GeneTree; ENSGT00840000129915; -.
DR HOGENOM; CLU_041874_0_0_1; -.
DR InParanoid; F6UH76; -.
DR OMA; PGLQCIG; -.
DR OrthoDB; 5385594at2759; -.
DR TreeFam; TF352039; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000002101; Expressed in ovary and 9 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0070330; F:aromatase activity; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:Ensembl.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0006710; P:androgen catabolic process; IEA:Ensembl.
DR GO; GO:0008585; P:female gonad development; IBA:GO_Central.
DR GO; GO:2000866; P:positive regulation of estradiol secretion; IEA:Ensembl.
DR GO; GO:0032355; P:response to estradiol; IBA:GO_Central.
DR CDD; cd20616; CYP19A1; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24291:SF43; AROMATASE; 1.
DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
SQ SEQUENCE 503 AA; 57710 MW; C7DA2C50CE98D7EF CRC64;
MILEMLNPMH YNLTGMVPEA MPAATMPILL LTCFLLLVWS YEDTSLIPGP GYCMGIGPLL
SHGRFLWMGI GSACNYYNKM YGEFMRVWIC GEETLIISKS SSMFHIMKHS HYISRFGSKL
GLQCIGMHEN GVIFNNNPAL WKAIRPFFTK ALSGPGLVRM VAVWYNSTVI HLDKLEDVTN
ETGYGHVLNL MRRIMLDTSN VSLLGIPLDE NAIVVKIQSY FDAWQALLLK PDIFFKISWL
YKKYEKSVKD LKDALEILIE EKRHRLSTDD KLEDCMDFAS QLIFAQGRGD LTGENVNQCI
LEMLIAAPDT LSVTVYFMLL LIAKHPKVEE AVMKEIQTVI GERDIKIGDV QKLKVVESFI
YESMRYQPVV DLVMRKALQD DVIDGYPVKR GTNIILNIGR MHRLEFFPKP NEFTLENFAK
NVPHRYFQPF GFGPRGCAGK YIAMVMMKVI LVTVLRRFHV QTLTGCCLER IQKKNDLSLH
PDETRDFLEM IFIPRNTEKC QEQ
//
