ID F6UK15_CIOIN Unreviewed; 435 AA.
AC F6UK15;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=DM2 domain-containing protein {ECO:0000259|PROSITE:PS51925};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000003409.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000003409.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SMARCD family.
CC {ECO:0000256|ARBA:ARBA00010619}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EAAA01002634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6UK15; -.
DR STRING; 7719.ENSCINP00000003409; -.
DR Ensembl; ENSCINT00000003409.3; ENSCINP00000003409.3; ENSCING00000013288.2.
DR GeneTree; ENSGT00940000156629; -.
DR HOGENOM; CLU_023529_0_2_1; -.
DR InParanoid; F6UK15; -.
DR OMA; PSMEASY; -.
DR TreeFam; TF106486; -.
DR Proteomes; UP000008144; Chromosome 8.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.245.10; SWIB/MDM2 domain; 1.
DR InterPro; IPR019835; SWIB_domain.
DR InterPro; IPR036885; SWIB_MDM2_dom_sf.
DR InterPro; IPR003121; SWIB_MDM2_domain.
DR PANTHER; PTHR13844:SF7; BRAHMA-ASSOCIATED PROTEIN OF 60 KDA; 1.
DR PANTHER; PTHR13844; SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D; 1.
DR Pfam; PF02201; SWIB; 1.
DR SMART; SM00151; SWIB; 1.
DR SUPFAM; SSF47592; SWIB/MDM2 domain; 1.
DR PROSITE; PS51925; SWIB_MDM2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 210..287
FT /note="DM2"
FT /evidence="ECO:0000259|PROSITE:PS51925"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 435 AA; 50751 MW; CE96ED261AFF3209 CRC64;
MHNSPSRTEP PRKRPGVSHQ TNATPISSSQ ADIRNKQVFT KKKKLSDKVL PQSVRDLVPE
SQAYMDLLAF ERKLDSTIMR KRLDIQEALK RPVKVKRKLR VFISNQFFPA KTDSDAKEET
AKASWELRVE GRLLDLPQPN PSNRHETKHK RKFSSFFKSL VIELDKDLYG PDNHLVEWHR
TQTTQETDGF QVKRQGDKNV RCTMLFMLNY LPPQFKLDSR LARLLGIHTQ SRPVIIQGLW
QYIKTHNLQD NHEREIINCD PYLEQLLGKS RIRFADVPQL LQPLLHPPDP IVIQHVISVD
PADAKKQACY DIEVEIDDTL KTQMSSFLLS SASQQDIADL ERRIHDTVAN VKQHRIQREF
YMGFSDNPQE FIADWISSQT KDLKTMTDAT GNKEEERLAD YYYAPWSQEA VNRYFYSKLQ
QRRIELDQVL KSSNI
//
