ID F6UP56_MACMU Unreviewed; 462 AA.
AC F6UP56;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Transcriptional enhancer factor TEF-3 {ECO:0000256|PIRNR:PIRNR002603};
GN Name=TULP3 {ECO:0000313|VGNC:VGNC:78677};
GN Synonyms=TEAD4 {ECO:0000313|Ensembl:ENSMMUP00000014816.4};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000014816.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000014816.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000014816.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription factor which plays a key role in the Hippo
CC signaling pathway, a pathway involved in organ size control and tumor
CC suppression by restricting proliferation and promoting apoptosis.
CC {ECO:0000256|PIRNR:PIRNR002603}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR002603}.
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DR AlphaFoldDB; F6UP56; -.
DR SMR; F6UP56; -.
DR Ensembl; ENSMMUT00000015814.4; ENSMMUP00000014816.4; ENSMMUG00000004172.4.
DR VEuPathDB; HostDB:ENSMMUG00000004172; -.
DR VGNC; VGNC:78677; TULP3.
DR GeneTree; ENSGT00940000158155; -.
DR HOGENOM; CLU_012515_0_0_1; -.
DR OMA; TAFHRKV; -.
DR TreeFam; TF313443; -.
DR Proteomes; UP000006718; Chromosome 11.
DR Bgee; ENSMMUG00000004172; Expressed in hindlimb stylopod muscle and 20 other cell types or tissues.
DR ExpressionAtlas; F6UP56; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0035329; P:hippo signaling; IEA:UniProtKB-UniRule.
DR Gene3D; 2.70.50.80; -; 1.
DR Gene3D; 6.10.20.40; TEA/ATTS domain; 1.
DR InterPro; IPR000818; TEA/ATTS_dom.
DR InterPro; IPR038096; TEA/ATTS_sf.
DR InterPro; IPR027255; TEF-3.
DR InterPro; IPR016361; TEF_metazoa.
DR InterPro; IPR041086; YBD.
DR PANTHER; PTHR11834; TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED; 1.
DR PANTHER; PTHR11834:SF2; TRANSCRIPTIONAL ENHANCER FACTOR TEF-3; 1.
DR Pfam; PF01285; TEA; 1.
DR Pfam; PF17725; YBD; 1.
DR PIRSF; PIRSF002603; TEF; 1.
DR PIRSF; PIRSF500722; TEF-3; 1.
DR PRINTS; PR00065; TEADOMAIN.
DR SMART; SM00426; TEA; 1.
DR PROSITE; PS00554; TEA_1; 1.
DR PROSITE; PS51088; TEA_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|PIRNR:PIRNR002603};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR002603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR002603};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR002603};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR002603}.
FT DOMAIN 64..140
FT /note="TEA"
FT /evidence="ECO:0000259|PROSITE:PS51088"
FT DNA_BIND 64..140
FT /note="TEA"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00505"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..241
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 51032 MW; B4B26AF8EE43D3D8 CRC64;
MTHTVRPLLT GAAVPVPTGP TGAPPSGALE GKAGTITSNE WSSPNSPEGS NVSGGSQALD
KPIDNDAEGV WSPDIEQSFQ EALAIYPPCG RRKIILSDEG KMYGRNELIA RYIKLRTGKT
RTRKQVSSHI QVLARRKARE IQAKLKDQAA KDKALQSMAA MSSAQIISAT AFHSSMALAR
GPGRSAVSGF WQGALPGQAG TSHDVKPFSQ QTYAVQPPLP LPGFESPAGP APSPSAPPAP
PWQGRSVASS KLWMLEFSAF LEQQQDPDTY NKHLFVHIGQ SSPSYSDPYL EAVDIRQIYD
KFPEKKGGLK ELFERGPSNA FFLVKFWADL NTNIEDEGSS FYGVSSQYES PENMIITCST
KVCSFGKQVV EKVETEYARY ENGHYSYRIH RSPLCEYMIN FIHKLKHLPE KYMMNSVLEN
FTILQVVTNR DTQETLLCIA YVFEVSASEH GAQHHIYRLV KE
//
