ID F6URV4_HORSE Unreviewed; 542 AA.
AC F6URV4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Apoptosis antagonizing transcription factor {ECO:0000313|Ensembl:ENSECAP00000006639.3};
GN Name=AATF {ECO:0000313|VGNC:VGNC:14896};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000006639.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000006639.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006639.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000006639.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006639.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AATF family.
CC {ECO:0000256|ARBA:ARBA00008966}.
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DR AlphaFoldDB; F6URV4; -.
DR STRING; 9796.ENSECAP00000006639; -.
DR PaxDb; 9796-ENSECAP00000006639; -.
DR Ensembl; ENSECAT00000008813.3; ENSECAP00000006639.3; ENSECAG00000008531.3.
DR CTD; 26574; -.
DR VGNC; VGNC:14896; AATF.
DR GeneTree; ENSGT00390000000288; -.
DR HOGENOM; CLU_018299_1_2_1; -.
DR InParanoid; F6URV4; -.
DR OMA; RRIRYHV; -.
DR OrthoDB; 26012at2759; -.
DR TreeFam; TF324341; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000008531; Expressed in trophectoderm and 23 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR025160; AATF.
DR InterPro; IPR039223; AATF/Bfr2.
DR InterPro; IPR012617; AATF_C.
DR PANTHER; PTHR15565; AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR15565:SF0; PROTEIN AATF; 1.
DR Pfam; PF13339; AATF-Che1; 1.
DR Pfam; PF08164; TRAUB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 226..379
FT /note="AATF leucine zipper-containing"
FT /evidence="ECO:0000259|Pfam:PF13339"
FT DOMAIN 470..524
FT /note="Apoptosis-antagonizing transcription factor C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08164"
FT REGION 13..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..132
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..207
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 542 AA; 61025 MW; F2CDD7A5B1D93291 CRC64;
MARPQPLALQ LEQLLNPRPR EADPEADPEE ATAARVIDRF DEGEDGEGDF PAVGSIRKLA
SASLLDTDKR YSGKTTSRKA WKEDHWEQTL PGSSDEEISD EEESDDGDSE GLGLEESDED
AMSAAEEQEC GDDGDSSLGR KKNSRSGSVT IPGFSVQSIS DFEKFTEGMD DVGSSEEEED
EEESGVEEGD GEEDVEGESE EDRGEDRNSE DDGVVMTFSS VKVSEEVEKG RAVKNQIALW
DQLLEGRIKL QKALLTTNQL PQPDVFPIFK DKGGPEFASA LKNSHKALKA LLRSLVDLQE
ELLFQYPDTR YLVDGTKPKV ESEEEISSED EELVEEKQRR RRAPAKRKLA MDDYPGFMAK
RFADFTVYRN HTLQKWHDKT KLASGKLGKG FGAFERSILT QIDHILMDKE RLLRRTQTKR
SVYRVLGKPE PAAQPVPESL PGQPEILPEA PANAHLKDLD EEIFDDDDFY HQLLRELIER
KTSSLDPNDQ VAMGRQWLAI QKLRSKIHKK VDRKASKGRK LRSELYRSLF GQLGPPDEGQ
RD
//
