ID F6URY7_XENTR Unreviewed; 2329 AA.
AC F6URY7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 24-JAN-2024, entry version 77.
DE RecName: Full=acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00013058};
DE EC=6.4.1.2 {ECO:0000256|ARBA:ARBA00013058};
GN Name=acaca {ECO:0000313|Ensembl:ENSXETP00000019619};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000019619};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000019619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000019619};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000019619}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
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DR Ensembl; ENSXETT00000019619; ENSXETP00000019619; ENSXETG00000008955.
DR Xenbase; XB-GENE-1013637; acaca.
DR eggNOG; KOG0368; Eukaryota.
DR HOGENOM; CLU_000395_5_0_1; -.
DR TreeFam; TF300061; -.
DR UniPathway; UPA00655; UER00711.
DR Bgee; ENSXETG00000008955; Expressed in brain and 12 other cell types or tissues.
DR ExpressionAtlas; F6URY7; baseline.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR45728:SF5; ACETYL-COA CARBOXYLASE 1; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 121..622
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 275..470
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 749..823
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 1558..1896
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 1900..2216
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 2329 AA; 263211 MW; 28E819618AC4F8BE CRC64;
MGHFFPPDPP LSKLLDQHSR FIIGSVSEDN SEDEFSSMVR VDLEDKERSS SPASIASTAS
DTLSDMGLSN YQDNLALQMR PSMSGLHLVK QGRDRKKIDL QRDFTVASPA EFVTRFGGNK
VIEKVLIANN GIAAVKCMRS IRRWSYEMFR NERAIRFVVM VTPEDLKANA EYIKMADHYV
PVPGGPNNNN YANVELILDI AKRIPVQAVW AGWGHASENP KLPELLLKNG IAFMGPPSQA
MWALGDKIAS SIVAQTAGIP TLPWSGSGLK VDWQESDLKK STLIVPPEVY GKGYVKDVDD
GLKAAEVVGY PVMIKASEGG GGKGIRKVNN AEDFPNLFRQ VQAEVPGSPI FVMRLAKQSR
HLEVQILSDQ YGNAISLFGR DCSVQRRHQK IIEEAPASIA TATIFEQMEQ CAVKLAKMVG
YVSAGTVEYL YSQDGSFYFL ELNPRLQVEH PCTEMVADVN LPAAQLQIAM GVPLHRIKDI
RMLYGLPAWG DSPIDFDNSL NAPCPRGHVI AARITSENPD EGFKPSSGTV QELNFRSNKN
VWGYFSVAAA GGLHEFADSQ FGHCFSWGEN REEAISNMVV ALKELSIRGD FRTTVEYLIK
LLETESFQNN RIDTGWLDRL ISEKVQAERP DAMLGVVCGA LHVADVTFRN SVSNFLHSLE
RGQVLPAHTL LNTVDVELIY EGEKYVLKVT RQSPNSYVVI MNNSCVEVDV HRLSDGGLLL
SYDGSSYTTY MKEEVDRYRI TIGNKTCVFE KENDPSILRS PSAGKLIQYV VEDGGHVFAG
QCYAEIEVMK MVMTLTAVES GCIHYVKRPG AALEPGCVIA KLQLDDPSRV QQAELHRGPL
PLIHSTALRG EKLHRVFHCV LDNLVNVMNG YCLPEPYFSS KLKDWVERLM KTLRDPSLPL
LELQDIMTSV SGRIPPNVEK SIKKEMAQYA SNITSVLCQF PSQQIANILD SHAATLNRKS
DREVFFMNTQ SIVQLVQRYR SGIRGHMKAV VMDLLRQYLK VETQFQHGHY DKCVFALREE
NKSDLTMVLN SIFSHAQVTK KNLLITMLID QLCGRDPTLT DELLNILMEL TQLSKTTNAK
VALRARQVLI ASHLPSYELR HNQVESIFLS AIDMYGHQFC IENLQKLILS ETSIFDVLPN
FFYHSNQVVR MAALEVYVRR AYIAYELNSV QHRQLKDNTC VVEFQFMLPT SHPNRMSFSS
NLNHYGMVHV VSDVLLDTSF TPPCQRMGGM VAFRTFEDFV RLFDDVMSCF SDSPPQSPVF
PEAGHPSLYD EDDNKVPINE PIHILNVAIK TDCDIDDDGL AAMFREFTQS KVTFFPCCLF
LCLAFLFLHK DFRKQVNCEV DQRFQFEEDR IYRHLEPALA FQLELNRMRN FDLTAIPCAN
HKMHLYLGAA KVEVGTEVTD YRFFVRAIIR HSDLVTKEAS FEYLQNEGER LLLEAMDELE
VAFNNTNVRT DCNHIFLNFV PTVIMDPSKI EESVRSMVMR YGSRLWKLRV LQAELKINIR
LTPTGKQIPI RLFLTNESGY YLDISLYKEV TDSRTAQIMF QAYGDKQGPL HGMLINTPYV
TKDLLQSKRF QAQSLGTTYV YDIPEMFRQA LIKLWESMEA HAFLPKSPLP SDVLTYTELV
LDDQGQLVHM NRLPGGNEIG MVAWKMTLKS PEYPDGRDII VIGNDITYKI GSFGPQEDLL
YLRASELSRS EGIPRIYVAA NSGARIGLAE EIRHMFHVAW EDPADPYKGF KYLYLTPQDY
KKVSALNSVH CEHVEDEGES RYKITDIIGK EEGLGVENLR GSGMIAGESS LAYEEIITIN
LVTCRAIGIG AYLVRLGQRT IQVENSHIIL TGAGALNKVL GREVYTSNNQ LGGIQIMHNN
GVTHSTVYDD FEGVYTILQW LSYMPKCVAS PVPILTPKDS IERLIEFTHT KAPYDPRWML
AGRPHPTQKG QWLSGFFDYG SFMEIMQPWA QTVVVGRARL GGIPVGVVAV ETRTVELSVP
ADPANLDSEA KIIQQAGQVW FPDSAFKTAQ AIKDFNREGL PLMVFANWRG FSGGMKDMYD
QVLKFGAYIV DGLREYRQPV LVYIPPQAEL RGGSWVVIDP TINPRHMEMY ADKESRGGVL
EPEGTVEIKF RRKDLIKTMR RVDPVYIHLA EKLGTPELGA ADCKELETKL KEREEFLLPI
YHQVAVQFAD LHDTPGRMQE KGVITDVIEW KTSRTFFYWR LRRLLLENVA KKKIHSANPE
LTDGQIQAML RRWFVEVEGT VKAYLWDNNK DVVEWLEKQM AEEEGTRSVV DENIKYISRD
YILKQIRSLV QENPEVAMDS IVHMTQHISP TQRAEIVRIL STMDSPTSS
//