ID F6US11_HORSE Unreviewed; 1057 AA.
AC F6US11;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSECAP00000006633.3};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSECAP00000006633.3,
GN ECO:0000313|VGNC:VGNC:17912};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000006633.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000006633.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006633.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000006633.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006633.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005610830.1; XM_005610773.2.
DR AlphaFoldDB; F6US11; -.
DR SMR; F6US11; -.
DR STRING; 9796.ENSECAP00000006633; -.
DR PaxDb; 9796-ENSECAP00000006633; -.
DR Ensembl; ENSECAT00000008807.4; ENSECAP00000006633.3; ENSECAG00000008144.4.
DR VGNC; VGNC:17912; FARP2.
DR GeneTree; ENSGT00940000158642; -.
DR HOGENOM; CLU_012301_0_0_1; -.
DR InParanoid; F6US11; -.
DR OMA; HKHMPED; -.
DR OrthoDB; 2876516at2759; -.
DR TreeFam; TF351276; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000008144; Expressed in retina and 23 other cell types or tissues.
DR ExpressionAtlas; F6US11; baseline.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17190; FERM_F1_FARP2; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 51..331
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 554..745
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 774..871
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 948..1045
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 419..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..913
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1057 AA; 120159 MW; 81D7E9951C41DEA2 CRC64;
MGEIEGTYRI LQTPGTRLGT QIPAGVSTLE PGQSLSAGTG QTSARMQEKH LHVRVKLLDN
TVEIFDIEPK CDGQTLLTHV WRRLNLIECD YFGLEFQNSQ SCWIWLEPMK PIIRQVRRPK
NAMLRLAVKF FPPDPGQLQE EYTRYLFALQ LRRDLLEERL TCTDTTAALL TSHLLQSEIG
DYDEALDREH LKVNEYLPSQ ERSLEKILEF HRKHTGQTPA ESDFQVLEIA RKLEMYGIRF
HTASDREGAK INLAVSHMGV LVFQSTTKIN TFNWSRVRKL SFKRKRFLVK LHPEVHGPYQ
DTLEFLLGSR DECKNFWKIC VEYHTFFRLF DQPKPKAKAV FFSRGSSFRY SGRTQKQLAD
YVKDGGMKRI PYERRHSKTR LSIRALTADL PRQSISFTEG VRTSASPSAI NASFYSVPTS
PLAPPGPPDF KDSSGSLTEP QAPDVKRPAA ERSSGAAAEG PDSRWAQPPG APALQPCQGL
IMESPQPSPS TQKSPLSLSP AFQVTLGPAE QGSSPLLSPV LSNAGGARMD DEEEPKHKKL
VRTNNIRKCT AADEAYFIAK EILATERTYL KDLEVITVWF RSAVVKEDAM PADLMTLLFS
NIDPIYEFHR GFLHEVEQRL ALWEGSSNAH ATGGHQRIGD VLLRNMQQLK EFTSYFQRHD
EVLTELEKAT KRSKKLEMVY KEFELQKVCY LPLNTFLLKP IQRLVHYRLL LSRLCGHYVP
GHRDHADCRD ALKAITEVTS TLQHSLVRLE NLQKLTELQR DLVGIENLIT PGREFIREGC
LHKLTRKGLQ QRMFFLFSDM LLYTSKGVSG TSHFRIRGLL PLRGMLVEES ESEWSVPHCF
TIYAAQKTMV VAASTRLEKE KWMHDLNTAI EAAKSGADAS LALPGSMVCT PPHRSSDEVS
LEQESEEDAR STHSSLEGQG QHRANTTVHV CWYRNTSVSR ADHIAAVENQ LSGYLLRKFK
NSTGWQKLWV VFTNFCLFFY KTHQDDYPLA SLPLLGYSVS VPRAADGIHK EHVFKLQFKS
HIYFFRAESK YTFGRWMEVI ERASSSPGRP GPPEEEA
//
