ID F6UWF5_HORSE Unreviewed; 1325 AA.
AC F6UWF5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Kinesin family member 16B {ECO:0000313|Ensembl:ENSECAP00000006137.2};
GN Name=KIF16B {ECO:0000313|Ensembl:ENSECAP00000006137.2,
GN ECO:0000313|VGNC:VGNC:19396};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000006137.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000006137.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006137.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000006137.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006137.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR RefSeq; XP_014590511.1; XM_014735025.1.
DR Ensembl; ENSECAT00000008226.3; ENSECAP00000006137.2; ENSECAG00000007559.4.
DR GeneID; 100050906; -.
DR CTD; 55614; -.
DR VGNC; VGNC:19396; KIF16B.
DR GeneTree; ENSGT00940000162977; -.
DR HOGENOM; CLU_001485_35_0_1; -.
DR OMA; HWHGAQQ; -.
DR OrthoDB; 126886at2759; -.
DR TreeFam; TF105221; -.
DR Proteomes; UP000002281; Chromosome 22.
DR Bgee; ENSECAG00000007559; Expressed in liver and 23 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22732; FHA_KIF16B; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd06874; PX_KIF16B_SNX23; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF6; KINESIN-LIKE PROTEIN KIF1C ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF00787; PX; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 3..358
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1190..1304
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1044..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 373..421
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 610..818
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 844..882
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 950..1030
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1044..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 102..109
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1325 AA; 152547 MW; 4C203F1C8D8A8A7F CRC64;
MASVKVAVRV RPMNRREKDL EAKFIIHMEK SKTTITNLKI PEGGTGDSGR ERTKTFTYDF
SFYSADTKSP DYVSQEMVFK TLGTDVVKSA FEGYNACVFA YGQTGSGKSY TMMGDSGDSG
LIPRICEGLF SRINETTRWD EASFRTEVSY LEIYNEHVRD LLRRKSSKTF NLRVREHPKE
GPYVEDLSKH LVQNYGDVEE LMDAGNINRT TAATGMNDVS SRSHAIFTIK FTQAKFDSEM
PCETVSKIHL VDLAGSERAD ATGATGVRLK EGGNINKSLV TLGNVISALA DLSQDAANPL
VKKKQVFVPY RDSVLTWLLK DSLGGNSKTI MIATISPADV NYGETLSTLR YANRAKNIIN
KPTINEDANV KLIRELRAEI ARLKTLLAQG NQIALLDSPT ALSMEEKLQQ NEARVQELTK
EWTNKWNETQ NILKEQTLAL RKEGIGVVLD SELPHLIGID DDLLSTGIIL YHLKEGQTYV
GREDASTEQD IVLHGLDLES EHCIFENVGG TVTLIPLSGS QCSVNGVQIT EATHLNQGAV
ILLGRTNMFR FNHPKEAAKL REKRKSGLLS SFSLSMTDLS KSCENLSAVM LYNPGLFPIK
GPICLRLEFE RQQREELEKL ESKRKLIEEM EEKQKSDKAE LERMQQEVET QRRETEIVQL
QIRKQEESLK RRSVHIESKL KDLLAEKEKF EEERLREQQE IELQKKKQEE ESFLRVKEEL
QRLQELNHNE KAEKTQIFQE LDQLKKEKDE QYAKFELEKK RLEEQEKEQV MLVAHLEEQL
REKQEMIGLL RRGEVQRVEE EKRALEGIRE ALLRVKEARA EGDDDGEELE RAQLHFLEFK
SRQLVKLANL EKDLVQQKDL LEKEVEEEKE ILERLKSENE EEFGLLEKND DSVTLGTQNL
ERIKPAEYRL QYKERQLQYL LQNRLPTLLE EKQRAFEILD RGPLGLDNTL YQVEKEMEEK
EEQLARYQAN ASQLQKLQAT FEFTANIARQ EEKVRRKEKE ILESREKQQR EALERAVARL
ERRHSALQRR STLGVEIEEQ RQKLATLNSS SSEQSGLRAS LEAEQEALER DQERLEHEIQ
QLKQKICEFD GVQKGHSETL EEKAASSRLP SSAEKSHLVP LMDARINAYI EEEVQRRLQD
LHHVIGSDSN TSADLMKDNE KLHNGTIQRK LKYERMVSRS LGANPDDLKD PIKISIPRYV
LCGQGKDEHF EFEVKITVLD ETWTVFRRYS RFREMHKTLK LKYAELATLE FPPKKLFGNK
DERVVAERRS HLEKYLRDFF SVMLQSATSP LHISKVGLTL SKHTICEFSP FFKKGVFDYS
SHGTG
//
