ID F6UY83_CALJA Unreviewed; 4103 AA.
AC F6UY83;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PRKDC {ECO:0000313|Ensembl:ENSCJAP00000025126.4};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000025126.4, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000025126.4}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000025126.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR Ensembl; ENSCJAT00000026554.5; ENSCJAP00000025126.4; ENSCJAG00000013572.5.
DR GeneTree; ENSGT00940000155633; -.
DR HOGENOM; CLU_224534_0_0_1; -.
DR Proteomes; UP000008225; Chromosome 16.
DR Bgee; ENSCJAG00000013572; Expressed in ovary and 6 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0048584; P:positive regulation of response to stimulus; IEA:UniProt.
DR GO; GO:0080135; P:regulation of cellular response to stress; IEA:UniProt.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2880..3545
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3728..4028
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4071..4103
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3202..3230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3211..3230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4103 AA; 466594 MW; FB87EB931CC77CE4 CRC64;
MAGSGAGVRC SLLRLQETLS AADRCGAALA GHQLIRGLGQ ECVLSGSPAL LALQTSLVFS
RDFGLLVFVR KSLNSIEFRE CREEILKFLC IFLEKMGQKM APYCLEIKNT CTSVYTKDRA
AKCKIPALDL LIKLLQTFRS SRLMDELKIG ELFSKFYGEL ALKKKIPDTV LEKVYELLGL
LGEVHPSEMI NNAENLFRAF LGELKTQMTS AVREPKLPVV AGCLKGLSSL LCNFTKSMEE
DPQTSKEIFN FVLKAIRPQI DLKRYAVPSA GLRLFALHAS QFSTCLLDKY VSLFEVLLKW
CAHTNVELKK AAQSALESFL KQVSYMVAKN AEMHKSKLQY FMEQFYGIIR NMDSNNKELS
IAIRGYGLFA GPCKVINAKD VDIMYIELIQ RCKQMFLTQT DIGDDRVYQM PSFLQSVASV
LLYLDTVPEV YTPVLEHLVV MQIDSFPQYS PKMQLVCCRA VVKVFLALAA KGPVLRNCIS
TVVHQGLIRI CSKPVVLPKG AESESEDHRA SGEVRTGKWK VPTYKDYVDL FRHLLSSDQM
MDSILADEAF FSVNSSHQSL NHLLYDEFVK SVLKIVEKLD LTLETQTVGE QENGDEAPGV
WVIPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKQVE FFEPWVYSFS HELILQSTRL
PLISGFYKLL SITVRNAKKI NYFEGVSPKS LQHSPEDPEK YSCFALFRKF GKEVAVKMKQ
YKDELLASCL TFLLSLPHDI IELDLRAYVP VLQMAFKLGL SHTPLAEVGL SALEEWSVYI
HKHEMQPYYK DILPFLDGYL KTSALSDETK SNWEVSALSR AAQKGFNKIV LKHLKKAKNL
SSSEAMSLEE IRIRIVQMLG SLGGQINKNL LAVASSDEMM KRYVAWDREK RLSFAVPFRE
MKPVIFLDVF LPRVTELALT ASDRQTKVAA CELLHSMVMF MLGKATQMPE GGQGVPPMYQ
LYKRTFPVLL RLACDVDQVT RQLYEPLVMQ LIHWFTNNKK FESQDTVALL EAILDGIVDS
VDSTLRDFCG RCIREFLKWS IKQTTPQQQE KSPVNTKSLF KRLYSLALHP NAFKRLGASL
AFNNIYREFR EEESLVEQFV FEAFVIYMES LALAHTDEKC LGTIQQCCDA IDHLCRIIEK
KHVSLNKAKK RRVPRGFPPS ASLCLLDLVK WLLANCGRPQ TECRHKSIEL FYKFVPLLPG
NRSPNLWLKD VLKEEGVSFL INIFEGGSCR QPSGILAQPT LLHLRGPFSL RATLCWLDLL
LAALECYNTF IGERTVGAFQ VLGIEAQSSL LKAVAFFLES IAMHDIVAAE KCFGAGAAGT
TPSPQEGERY NYSKCTVVVR IMEFTTTLLN TSPEGWKLLK KDLCNTHLMR VLVQTLCEPA
SVGFSIGDIQ VMDHLPDVCV NLMKALKMSP YEDTLETHLR EKITARRIEE LCAVNLYGPD
AQVHRSRLAA VVSACKQLHR AELLHAILPS QSTDLPHSLG TELLTLVYKS IAPGDERQCL
PPLDPSCKQL ATGLLEFAFA FGGLCERLVS LLLNPVLLST PSLGSSQSSV IHFSHGEYFY
SLFSETINTE LLKNMDLAVL ELMQSSMDNP KMVSAVLNGM LDQSFRERAS QKHQGLKLAT
VILQHWKKCD SWWAKESPLE SKMAVLTLLA KLLQIDSSVS FNTSHGSFPE VFTTYLSLLA
DTKLDLHLKG QAVTLLPFFT SLTGGSLEEL RRVLEQLIVA HFPMQSREFP AGTPRYNNYV
DCMKKFLDAL EQSQSPMLLE LMTEVLCREH HHVMEDLFQS SFKRIARRGS CVTQVGLLES
VYEMFRKDDP RLSFTRQSFV DRSLLTLLSH CSLDALREFF SRIVVDAIDV LKSRFTKLNE
STFDTQITKK MGYYKMLDVM YSRLPKDDVH AKESKINQAF HGSCITEGNE LTKTLIKLCY
DAFTENMAGE NQLLERRRLY HCAAYNCTIS VICCVFNELK FYQGFLFSEK PEKNLLIFEN
LIDLKHRYNF PVEVEIPMER RKKYIEIRKE ARGAASGDSD GPSYMSSLSC LADSTLSEEM
SQFDFSTGVQ SYSYSSQDPR PTTGRFRRRM ITFHEQQDPA VHADVLELEM DELNRHECMA
PLTALVKHMH RSVGPPPGEE ESVLRDLPPW MKFLHGKLGN PIVPLNIRLF LAKLIVNTEE
VFRPYAKHWL SPLLQLAVSE NNGGEGIHYM VVEIVATVLS WTGLATPTGV PKDEVLANRL
LNFLMKHVFH PKRTVYRHNL EIIKTLVECW KDCLSIPYRL IFEKFSGKDP NSKDNSVGIQ
LLGIVMANDL PPYDPQCGIQ SSEYFQALVN NMSFVKYKEV YAAAAEVLGL ILRYVMERKN
ILEESLCELV AKQLKQHQNT MEDKFIVCLN KVTKSFPPLA DRFMNAVFFL LPKFHGVLKT
LCLEVVLCRV EAMTELYFQL KSKDFVQIMR HRDDERQKVC LDIVYKVMPK LKPVELRELL
NPVVEFVSHP STTCREQMYN ILMWIHDNYR DSESQTDNDS QEIFKLTKDV LIQGLIDENP
GLQLIIRNFW SHETRLPSNT LDRLLALNSL YSPKIEVHFL SLATNFLLEM TSMSPDYPNP
IFEHPLSECE FQECTIDSDW RFRSTILTPM FVETQASQGT LQTRTQEGSL STRWSTAGQL
RATQQHYDFT PTQTADGRSS FDWLTGSSTD PLADHTGPSS DSLLFAHKRS ERSQRVPLKS
VGPDFGKKRL GLPGDEVDNK VKGVAGRVDL LRLRRRFLRD QERLNLIYAR KSLAEQKREK
EMKSELKMKQ DAQVVLYRSY RHGDLPDIQI KHSSLITPLQ AVAQRDPIIA KLLFSSLFSG
ILKEMDKFKT LSEKNIITQK LLQDFSCFLS TTFSFFPPFV SCIQDISCQH AALLSLDPAA
VSASCLASLQ QPVGIRLLEE ALLRLLPSEL PAKRVRGKAR LPPDVLRWVE LAKLYRSIGE
YDVLRGIFSS EIGTKEITQN ALLAEARSNY SEAAKQYDEA LNKQDWVDGE PTEAEKDFWE
LASLDCYNHL AEWKSLEYCS TASVDSENPP DLNKIWSEPF YQETYLPYMV RSKLKLLLQG
EADQSLLTFI DKAMHGELQK VILELHYSQE MSLLYLLQDD LDRAKYYIQN GIQSFMQSYS
SIDVLLHRSR LTKLQSVQAL TEIQEFISFI SKQGNLSSQV NLKRLLNTWT NRYPDAKMDP
MNIWDDIITN RCFFLSKIEE KLTPPPEDSS MNVDEDGDPG DSGEMQEEQE EDISSLIRSC
KFSMKMKMMD SARKQNNFSL AMKLLKELHK ESKTRDDWLV SWVQSYCRLS HCRSRAQRCS
EQVLTVLKTV SLLDENNVSS YLSKNILAFR DQNILLGTTY RIIANALSSE PACLAEIEED
KARTILELSG SSSEDSEKVI AGLYQRAFQH LSEAVQAAEE EAQPSSWSCG PAAGVIDAYM
TLADFCDQQL RKEEENATVT DSAELQAYPA LVVEKMLKAL KLNSNEARLK FPRLLQIIER
YPEETLSLMT KEMSSVPCWQ FIGWISHMVA LLDKDQAIAV QHTVEEITDN YPQAIIYPFI
ISSESYSFKD TSTGHKNKEF VARIKSKLDH GGVIQDFINA LDQLSNPELL FKDWSNDVRA
ELAKTPVNKK NIEKMYERMY TTLGDPKAPG LGAFRRKFIQ TFGKEFDKHF GKGGSKLPRM
KLSDFNDITN MLLLKMNKDS KPPGNLKEWS PWMSDFKVEF LRNELEIPGQ YDGRGKPLLE
YHVRIAGFDE RVTVMASMRR PKRIIIRGHD ETEHPFLVKG GEDLRQDQRV EQLFQVMNGI
LAGDSACSQR ALQLRTYSVV PMTSSDPKAP LCEYRDWLTK MSGKHDVGAY MLMYKGANRT
ETVTSFRKRE SKVPADLLKR AFVRMSTSPQ TFLALRSHFA SSHALICISH WILGIGDRHL
NNFMVAMETG GMIGIDFGHA FGSATQFLPI PELMPFRLTR QFINLMLPMK EMGLMYSVMV
HALRAFRSDP GLLTNTMDVF VKDPSFDWKN FEQKMLKKGG SWIQDINVAE KNWYPRQKIC
YAKRKLAGAN PAVITCDELL LGHEKAPAFR DYVAVARGSK DHNIRAREPE GGLSEETQVK
CLMDQATDPN ILGRTWEGWE PWM
//
