ID F6V2P0_HORSE Unreviewed; 745 AA.
AC F6V2P0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=T cell activation RhoGTPase activating protein {ECO:0000313|Ensembl:ENSECAP00000018363.3};
GN Name=TAGAP {ECO:0000313|Ensembl:ENSECAP00000018363.3,
GN ECO:0000313|VGNC:VGNC:23858};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018363.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018363.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018363.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018363.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018363.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F6V2P0; -.
DR Ensembl; ENSECAT00000022234.3; ENSECAP00000018363.3; ENSECAG00000020888.4.
DR VGNC; VGNC:23858; TAGAP.
DR GeneTree; ENSGT00940000157993; -.
DR HOGENOM; CLU_014209_1_0_1; -.
DR TreeFam; TF331062; -.
DR Proteomes; UP000002281; Chromosome 31.
DR Bgee; ENSECAG00000020888; Expressed in blood and 19 other cell types or tissues.
DR ExpressionAtlas; F6V2P0; baseline.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR PANTHER; PTHR23179:SF26; T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 114..303
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 316..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 82963 MW; C31B406EBA7166AC CRC64;
MKPVLLGQSR GHTGAKFITG QSAQSLMKLI SSCNVSKTLN ANNMETLIEC QSEGDIKEHP
LLVSCESEES ICQLIEIKKT KKVLSWPFLM KRFSPSSDFS GASEPELKVS LFDQPLSIIC
GDDDTLPRPI QDILTILCIK GPSTEGIFRK GANEKARKEL KEELNSGGMV DLQSLPVHLL
AAVFKDFLRS IPLKLLSCDL FEEWMGALEK LNEEDRIEAL KQVAEKLPRP NLLLLKHLVS
VLYLISKNAV VTKMDASNLA ICVGPNMLSR DNDQNLSLEA QKDLNNKVKT LVEFLIDNCL
EIFGENIPVH SSIASDDSLE HTDSSDMSTL QNDSAYDSND PDVESSCAID SPSRRPQVPS
ETAAGLEPRG PQRTWELSRE PIVSTVARLK SSLSQLDRRY SEPNMPSSQE CLESRKTTQK
LTRSEDDFTM ARNSSHFESE EAEDPFPEEV FPAVESKTRR PQDLKVKYWT QGSGLPSGLV
PKAFSSGSLD ASSDSSPVAS PSSPQRSFFT RHQSFTKTEK SKPNREIKKH SMSFSFSSHK
KVLSKTSSFG SGKPKGFPRD QARKDLKKES QLAGRIVQED LSEIHGQTNL DISSRCYALS
VENVFQLVDQ RCPGSPPSYE ESIRCQALEL AAYGSQTVGS MRAKMLSQDS GLSALLPFHH
GGDSRNICHR EPLDGHGTES WKQRRTVCAS VETIGQVTVP RRPELPRLRT VSESKQKTKW
DYLVRRCSQP IFEADQLQFA RESYI
//