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Database: UniProt
Entry: F6V3D2_CANLF
LinkDB: F6V3D2_CANLF
Original site: F6V3D2_CANLF 
ID   F6V3D2_CANLF            Unreviewed;       412 AA.
AC   F6V3D2;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   16-OCT-2019, entry version 46.
DE   SubName: Full=Receptor associated protein of the synapse {ECO:0000313|Ensembl:ENSCAFP00000012765};
GN   Name=RAPSN {ECO:0000313|Ensembl:ENSCAFP00000012765,
GN   ECO:0000313|VGNC:VGNC:45350};
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC   Canis.
OX   NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000012765, ECO:0000313|Proteomes:UP000002254};
RN   [1] {ECO:0000313|Ensembl:ENSCAFP00000012765, ECO:0000313|Proteomes:UP000002254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000012765,
RC   ECO:0000313|Proteomes:UP000002254};
RX   PubMed=16341006; DOI=10.1038/nature04338;
RG   Broad Sequencing Platform;
RA   Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA   Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA   Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA   Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA   Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA   Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA   Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA   Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA   Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA   Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA   Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA   Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA   Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA   Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA   Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA   Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA   Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA   Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA   Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA   Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA   Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA   Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA   Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA   Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA   Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA   Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA   Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA   Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA   Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA   Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA   Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA   Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA   Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA   Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA   Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA   Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA   Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA   Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA   Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT   "Genome sequence, comparative analysis and haplotype structure of the
RT   domestic dog.";
RL   Nature 438:803-819(2005).
RN   [2] {ECO:0000313|Ensembl:ENSCAFP00000012765}
RP   IDENTIFICATION.
RC   STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000012765};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AAEX03011485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAEX03011486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_850095.1; XM_845002.4.
DR   SMR; F6V3D2; -.
DR   STRING; 9612.ENSCAFP00000012765; -.
DR   PaxDb; F6V3D2; -.
DR   Ensembl; ENSCAFT00000013802; ENSCAFP00000012765; ENSCAFG00000008690.
DR   GeneID; 609725; -.
DR   KEGG; cfa:609725; -.
DR   CTD; 5913; -.
DR   VGNC; VGNC:45350; RAPSN.
DR   eggNOG; KOG1941; Eukaryota.
DR   eggNOG; ENOG41103HX; LUCA.
DR   GeneTree; ENSGT00390000016785; -.
DR   OMA; MCGESIG; -.
DR   OrthoDB; 1245397at2759; -.
DR   TreeFam; TF328344; -.
DR   Proteomes; UP000002254; Chromosome 18.
DR   Bgee; ENSCAFG00000008690; Expressed in 2 organ(s), highest expression level in liver.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR   GO; GO:0099634; C:postsynaptic specialization membrane; IEA:Ensembl.
DR   GO; GO:0033130; F:acetylcholine receptor binding; IEA:Ensembl.
DR   GO; GO:0043495; F:protein membrane anchor; IEA:InterPro.
DR   GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0007271; P:synaptic transmission, cholinergic; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; -; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001237; Postsynaptic.
DR   InterPro; IPR018293; Postsynaptic_CS.
DR   InterPro; IPR019568; Rapsyn_myristoylation/link_N.
DR   InterPro; IPR013026; TPR-contain_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR041617; TPR_MalT.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF10579; Rapsyn_N; 1.
DR   Pfam; PF17874; TPR_MalT; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   PRINTS; PR00217; POSTSYNAPTIC.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00028; TPR; 7.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS00405; 43_KD_POSTSYNAPTIC; 1.
DR   PROSITE; PS50005; TPR; 5.
DR   PROSITE; PS50293; TPR_REGION; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002254};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   REPEAT        6     39       TPR. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00339}.
FT   DOMAIN      123    319       TPR_REGION. {ECO:0000259|PROSITE:
FT                                PS50293}.
FT   REPEAT      123    156       TPR. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00339}.
FT   REPEAT      163    196       TPR. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00339}.
FT   REPEAT      206    239       TPR. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00339}.
FT   REPEAT      286    319       TPR. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00339}.
FT   DOMAIN      363    403       RING-type. {ECO:0000259|PROSITE:PS50089}.
FT   COILED      302    329       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   412 AA;  46375 MW;  582E1889D81051E8 CRC64;
     MGQDQTKQQI EKGLQLYQSN QTEKALHVWM KVLEKSADLV GRFRVLGCLV TAHSEMGRYK
     EMLKFAVVQI DTARELEDAD FLLESYLNLA RSNEKLCEFH KTISYCKTCV GLPGTRAGAQ
     LGGQVSLSMG NAFLGLSLFQ KALESFEKAL RYAHNNDDTM LECRVCCSLG SFYAQVKDYE
     KALFFPCKAA ELVSDYGKGW SLKYRAMSQY HMAVAYRLLG HLGSAMECCE ESMKIALQHG
     DRPLQALCLL CFADIHRSRG DLETAFPRYD SAMSIMTEIG NRLGQVQVLL GVAKCWIARK
     ALDKALDVIE KAQDLAEEVG NKLSQLKLHC LSESIYRSKG LQRELRAHVV RFHECVEETE
     LYCGLCGESI GERNSRLQAL PCSHIFHLRC LQNNGTRSCP NCRRSSMKPG FV
//
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