ID F6V5D8_ORNAN Unreviewed; 425 AA.
AC F6V5D8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Arrestin domain containing 1 {ECO:0000313|Ensembl:ENSOANP00000023873.4};
GN Name=ARRDC1 {ECO:0000313|Ensembl:ENSOANP00000023873.4};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000023873.4, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000023873.4}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000023873.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the arrestin family.
CC {ECO:0000256|ARBA:ARBA00005298}.
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DR AlphaFoldDB; F6V5D8; -.
DR STRING; 9258.ENSOANP00000023873; -.
DR Ensembl; ENSOANT00000023877.4; ENSOANP00000023873.4; ENSOANG00000015161.4.
DR eggNOG; KOG3780; Eukaryota.
DR GeneTree; ENSGT00940000159652; -.
DR HOGENOM; CLU_051966_0_0_1; -.
DR InParanoid; F6V5D8; -.
DR OMA; TLMLKTR; -.
DR TreeFam; TF313650; -.
DR Proteomes; UP000002279; Unplaced.
DR Bgee; ENSOANG00000015161; Expressed in adult mammalian kidney and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:1903561; C:extracellular vesicle; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:1990763; F:arrestin family protein binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0006858; P:extracellular transport; IEA:Ensembl.
DR GO; GO:0140112; P:extracellular vesicle biogenesis; IEA:Ensembl.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR011022; Arrestin_C-like.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR11188; ARRESTIN DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11188:SF163; ARRESTIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF02752; Arrestin_C; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR SUPFAM; SSF81296; E set domains; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 7..139
FT /note="Arrestin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00339"
FT DOMAIN 194..272
FT /note="Arrestin C-terminal-like"
FT /evidence="ECO:0000259|Pfam:PF02752"
FT REGION 288..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..350
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 425 AA; 46313 MW; 72AF129BCCA40650 CRC64;
MGKLQLFEIQ LADSRVIYGP GQPLAGAVTV RLAAPLPYRA IKVTCMGSCG VSNKINDTAW
TVEEPYFNST LSLADKGTLS AGEHTFPFQF LLPATAPTSF EGPFGKVIHQ VRAVIDTPRF
SKDYKCNKVF YILCPLNLND IPDIEVRGLG RWVWEGTGSI CLALLRQWGR LWEALDISRS
LFLCVSVSLT PPRQKVSYKS KRWIYDLRTI AEVEGAAVKA WKHAEWREQI LVPALPQSIL
QGCNLIHIDY YLQVSLKAPE VSVSLPLFIG NIAVNRVPVS PSRLPLPVLP SAPPEDEDAD
AAGGRPAMDS VSISTKSHSQ QRPPPPPLGP APGPSSPDPR LDPEPGGSPG RPPLCLSTGA
TVPYFADGTV VPVPTAGSLI LPPEYSTWGY PYGEPAHSFV KFIRSYLSSA YCVQRAHKSR
GGDRH
//
