ID F6V6S5_HORSE Unreviewed; 472 AA.
AC F6V6S5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Submaxillary mucin-like protein {ECO:0008006|Google:ProtNLM};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000004954.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000004954.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000004954.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000004954.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000004954.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR AlphaFoldDB; F6V6S5; -.
DR STRING; 9796.ENSECAP00000004954; -.
DR PaxDb; 9796-ENSECAP00000004954; -.
DR Ensembl; ENSECAT00000006883.3; ENSECAP00000004954.3; ENSECAG00000006703.3.
DR GeneTree; ENSGT00720000108953; -.
DR HOGENOM; CLU_259988_0_0_1; -.
DR InParanoid; F6V6S5; -.
DR OMA; CEKEIIC; -.
DR TreeFam; TF337957; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000006703; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR47246; MUCIN-19; 1.
DR PANTHER; PTHR47246:SF1; MUCIN-19; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00214; VWC; 2.
DR PROSITE; PS01185; CTCK_1; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 249..315
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 382..464
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 49406 MW; 65374221305FC498 CRC64;
SGTTIISGSS HTGDTTAVPR GQATGSVTGT TGVTPGTTVA PGSSNTEATT SVGESGIRRI
EITTGTTEGI SGKTQKLGSA NTGASGTTGS YVPGNETGAT TSLESGRTTE GGIKIVTTGV
ITGTTIASGS SKAKATTSTE IQATTGARIV TGTTTLRLSN DTTRSGIRTG TTVVSSRITG
VPESSSPGTS KKASKTTVAP GIFTTGSTSV SSGITTSPEV SYPETPVATT GNQETENNTD
CPTSLPPPPV CHGPLGEEKS PGDIWTANCH RCTCTDAKAV DCQLQECPSP PTCQTGERLV
KFKANDTCCE IGYCEPRTCF FNNTDYEIGD SFDDPNNPCV SYSCGDTGLV AVVQDCPKQT
WCAEEDRVYD SNKCCYTCKA DCRSSPMNVT VKYNDCEKRV EMARCTGECE NTVKYNHDIL
ENSCLCCREE GYEFREIVLD CPDGSTMPYR YRHITTCSCL DMCQQSTTAM PS
//
