ID F6V8G3_CIOIN Unreviewed; 577 AA.
AC F6V8G3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Enolase 4 {ECO:0000256|ARBA:ARBA00034855};
DE EC=4.2.1.11 {ECO:0000256|ARBA:ARBA00012058};
DE AltName: Full=2-phospho-D-glycerate hydro-lyase {ECO:0000256|ARBA:ARBA00031125};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000022815.2, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000022815.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC glyceraldehyde 3-phosphate: step 4/5. {ECO:0000256|ARBA:ARBA00005031}.
CC -!- SIMILARITY: Belongs to the enolase family.
CC {ECO:0000256|ARBA:ARBA00009604}.
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DR EMBL; EAAA01002223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EAAA01002224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6V8G3; -.
DR STRING; 7719.ENSCINP00000022815; -.
DR Ensembl; ENSCINT00000023061.2; ENSCINP00000022815.2; ENSCING00000009849.3.
DR GeneTree; ENSGT00950000182805; -.
DR HOGENOM; CLU_493979_0_0_1; -.
DR InParanoid; F6V8G3; -.
DR OMA; DIRAREC; -.
DR TreeFam; TF354238; -.
DR UniPathway; UPA00109; UER00187.
DR Proteomes; UP000008144; Chromosome 5.
DR GO; GO:0000015; C:phosphopyruvate hydratase complex; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004634; F:phosphopyruvate hydratase activity; IBA:GO_Central.
DR GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR CDD; cd22974; DD_ENO4; 1.
DR Gene3D; 3.20.20.120; Enolase-like C-terminal domain; 1.
DR InterPro; IPR047500; DD_ENO4.
DR InterPro; IPR000941; Enolase.
DR InterPro; IPR036849; Enolase-like_C_sf.
DR InterPro; IPR029017; Enolase-like_N.
DR InterPro; IPR020810; Enolase_C.
DR PANTHER; PTHR11902; ENOLASE; 1.
DR PANTHER; PTHR11902:SF30; ENOLASE 4; 1.
DR Pfam; PF00113; Enolase_C; 1.
DR SMART; SM01192; Enolase_C; 1.
DR SUPFAM; SSF51604; Enolase C-terminal domain-like; 1.
DR SUPFAM; SSF54826; Enolase N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 250..538
FT /note="Enolase C-terminal TIM barrel"
FT /evidence="ECO:0000259|SMART:SM01192"
FT REGION 166..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 63340 MW; 2E79159D786A180B CRC64;
YSYVATEALN RQSKSYQELR QNAANYYAEN AVAPKLEEIL NKMFYEQPND VYGRLSEYFE
EFALTPNIVK ISANKVMDGV GAGGLQCSVF AEVKNQPKVL SSLSMSLEKE ISMLPLQQQH
TTERGCMHIS ESISSKLNNV SLLQQTEVDL MLRDWIDDAE YDKFIGANQP TEEDDGHSRT
PTPSSGRKKK TSSGKAKVGK VPEKPVPPKE PMEDRLKGCT AASAVSVAVL KAAANFLQKS
GIAQQNVDNT VTMPTPAMVV LSGGKSAPGK LHMLKNVFAI AKPGLTISES ISNLIKVYQN
VGKGLSAKSV NFDKIKQISA SGGYEPSYDK PEQPLDAILE AINTSGLVPG QDIFLGIECS
AHEIFDYDKG KYEISTGTLK TADEFIDLLK DLVMRYPSLI MIIDPLRRED REQWTKLCEM
VSEKCFIIGS DVIYGSMHSL NDNMLSARKS SGLVISTGSR VTCSDLARVV GDIRARECVT
IMTSPVGDVC DDIFSDLAVG LGATFVRFGA PSRGENTSKI NRFIEIERII NESKTSKINY
LSKFEFPVIK PPPPAPVSDE ENEIPAENSS PDQKKKK
//
