ID F6V9T9_XENTR Unreviewed; 578 AA.
AC F6V9T9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=T-box 18 {ECO:0000313|Ensembl:ENSXETP00000039371};
DE SubName: Full=T-box transcription factor TBX18 {ECO:0000313|RefSeq:XP_002933971.1};
GN Name=tbx18 {ECO:0000313|Ensembl:ENSXETP00000039371,
GN ECO:0000313|RefSeq:XP_002933971.1,
GN ECO:0000313|Xenbase:XB-GENE-489907};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000039371};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000039371}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000039371};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000039371}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_002933971.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002933971.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002933971.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR RefSeq; XP_002933971.1; XM_002933925.5.
DR Ensembl; ENSXETT00000039371; ENSXETP00000039371; ENSXETG00000018148.
DR GeneID; 100489044; -.
DR KEGG; xtr:100489044; -.
DR AGR; Xenbase:XB-GENE-489907; -.
DR CTD; 9096; -.
DR Xenbase; XB-GENE-489907; tbx18.
DR eggNOG; KOG3586; Eukaryota.
DR HOGENOM; CLU_030727_0_0_1; -.
DR OMA; NMSMSGN; -.
DR OrthoDB; 5323209at2759; -.
DR TreeFam; TF106341; -.
DR Proteomes; UP000008143; Chromosome 5.
DR Bgee; ENSXETG00000018148; Expressed in skeletal muscle tissue and 2 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20199; T-box_TBX18_like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF20; T-BOX TRANSCRIPTION FACTOR TBX18; 1.
DR Pfam; PF00907; T-box; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 116..303
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 27..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 62748 MW; 5888049F287E3BF1 CRC64;
MAEKRRSPCT MSLKAHAFSV EALIGAEKQQ QQKKKRKRAE DGAVERVAHS DGADGASSLH
LPQPGPPELE HSVCSILASS PCEDTYGGVK SGNGPCRSPI TPPAVPAQTA PVRVDLQGAE
LWKRFHEIGT EMIITKAGRR MFPAMRVKIT GLDPHQQYYI AMDIVPVDNK RYRYVYHSSK
WMVAGNADSP VPPRVYIHPD SPASGETWMR QVISFDKLKL TNNELDDQGH IILHSMHKYQ
PRVHVIRKDC GEELSPVKPI PVGEGEKAFS FPETIFTTVT AYQNQQITRL KIDRNPFAKG
FRDSGRNRMG LEALVESYAF WRPSLRTLTF EDIPGIPKQG SAGASSLLSG SGAANSHAHL
LPGSPCSSPA FHIGANTSQL CGLTPGDYSA CGRSSLALNR YSTTLAETYN RLTNSTSESF
ATPRTPSYVG MTSSTAMNMS MAGNDNETFG CPQTSLSMQI SGMSPQLQYI MPSPTSNAFS
SSQPHQSSYN AFRLHSPCAL YGYNFSTSPK LASSPEKILS SQGSFLGSSP SGTMTDRQIL
PPVEGVHLLS SAGQQNFFDS RSLGGLPISS SQISAHMV
//
