ID F6VAS4_MONDO Unreviewed; 3177 AA.
AC F6VAS4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Calx-beta domain-containing protein {ECO:0000259|SMART:SM00237};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000000500.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000000500.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000000500.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR STRING; 13616.ENSMODP00000000500; -.
DR Ensembl; ENSMODT00000000513.3; ENSMODP00000000500.3; ENSMODG00000000417.3.
DR eggNOG; KOG1306; Eukaryota.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000162501; -.
DR HOGENOM; CLU_000394_0_0_1; -.
DR InParanoid; F6VAS4; -.
DR OMA; ATKDIFY; -.
DR TreeFam; TF316876; -.
DR Proteomes; UP000002280; Chromosome 5.
DR Bgee; ENSMODG00000000417; Expressed in kidney and 5 other cell types or tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 5.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR045658; FRAS1-rel_N.
DR PANTHER; PTHR45739:SF5; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 3; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 5.
DR Pfam; PF19309; Frem_N; 1.
DR SMART; SM00237; Calx_beta; 5.
DR SUPFAM; SSF141072; CalX-like; 5.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..3177
FT /note="Calx-beta domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023880635"
FT TRANSMEM 3128..3149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 312..413
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 438..528
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 549..686
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 711..817
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 838..929
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 953..1044
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1073..1175
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1196..1289
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1310..1408
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1429..1521
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1541..1630
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1664..1761
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1768..1867
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1880..1991
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2006..2112
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2125..2229
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2247..2351
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 3031..3077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3155..3177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3031..3045
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3053..3067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3163..3177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3177 AA; 351465 MW; C0B820D1496C13C1 CRC64;
MTRSWHRPRG TPRQLLEVFA ALLLCCLALR AQTPEPKLWA SGPILGTRSH NHSSMGADIL
AASPGLRVPL GRSVWLDPAR NLVIRVQPGD RCMVMVLGKD GGRVAAVSPP AGLLSPASFP
CAFGPAQVRY THFGARSPAQ QQLRLQLRYD SQSQTLVLPF TMPVDVDFSQ SEVVTRNLPL
TVEKLRGFSN AIDQTVLNFS TASSLNGVPL TCRLTPLPRE TGAFPRYGRL VGPSGAPLPP
GRRMDCQAFL TAGVSYQHMT NPSSPNRDYV PFLVEIVGPE EEGDIKLSRI LVQEHFQMLV
KIQEGTENSP PRPSLGAMMM MEVDQFVLTA LTLESLAAED LESSPDDLVF NILNFSPALP
ESHGQQGYFI NTDNPLGQPI TSFTQQDLRE LKIAYQPPTD DSNQERLFQL ELEVVDVDGA
ASGPFAFMVV VKPMNTLAPL ASRNQGLLLF EGQSRPLSSA QSLEISDEDN LEEVRVTIVK
GLRHGQLVVL GAPTERKYFT SADLAAERVI YQHDGSDTYN DNIIFRMGDG QHDVEFFFSI
TIAPEDDEPP VVNTNTGLSL AEGEVVQISH FELSATDIDS EDSTIRFVLK RPALENEEKE
RGWDLAPTST LTMQHLGEVL LRQSKPPSPL MGKGGKGWTF VEKKGLYEKV VTEWLQQDIL
DGRLFYRHLG PHHPSSMLDQ LVFHVQDDHD PPNQSGQHFF TIMVQPVDVL SPELYSGVSL
EMIVKGYQLT PFQKEFLCYT DMDSDDWHLR YMILTPPTDV DNNHPVPAGE IVLMDAPTIP
ITQFTQAQVN HHKVAYQPPQ QEVGIVPRVV QFTYHVVDSA GNSVPGTFNL FLQPVNNQPP
EVINSGFTVK EGKNFILTSR ELGVIDPDTD ADKIVFTLVQ GPQHGHLLYL EGVMALGTYF
MSDDIVNGHV SYQHGGGETT NDAFQLVVSD RVHQVPITVR VTIKTVEDGI TIPGGGWVGT
SIEVLENGAT KMTTGIIQGK DKDTDIMLTF LVEKPPKLGI ILVNGLPTEQ FTQGDLINGA
VAYAHTGGEI GMQKQHDSFN LTISNHSDLW VNEGKIVEGV QVQVTVLPID SVPPEMKVGE
LFSVPEGGKS TLTLRHLDAK DIDTPHNDVL CTIIGQPSFG YLENISPAPG SEKSQAGSPI
SAFTIKDICQ GYINFVQSIH KGVEPREDQA TFHCSDGINF SPNHIFPIII LPTNDEQPEL
FTHEFVVLEG MSLVIDTPLL NTADADLPPD KLQFQITVLP QNGQIVQQLA TGSQPVHSFT
LEEIQEASTI VYEHDDSETT EDSFEVWVTD GKHMIHRKIP ITVILVDDET PRLIINDGLE
VDIGQTKVIT NQVLKATDLD SNDKDLAYIL RSGPRQGLLQ KLFEPRGRVG SNLTLGMNFT
QSEIDQGLIC YSHKGLEGIQ DIIRFDVTDG INPLIDRSFY VTISSTDKVF PEVINKGVTL
KEGARVILTT DLLSTSDINS PDEQLHFSIT RAPTRGHLES SDLPEEPISS FTQLQLAGNK
ISYVHTAEDE IKMDSFEFKV SDGHNSIFRT FCVSITDVDN KKPILTIHHL LVCEGEKKLI
TPFELSAEDQ DSPDGLLRFT ITHFPIHGQI LYNSSQPITN FTKQDLNENL ISYQHDGTET
TEDSFSFIVT DGTHTDFYIF PDTVLATHKP QVMKIQISSL DDGVPQIVVN KGAPALRLLQ
TGHLGFLITS KSLKAKDQDS LHKLLKYTVI SGPKHGSLIH LGLGNRNIKM FTQADIDEMK
IGYVLKEGSN ATSDIFYFSV EDTGGNKLRS QSFHLNWAWI SLEKEHYIID EDSKFLEVTL
KRRGYLGETS FINIGTKDGT AQKDKDFKGK PQKQVQFNPG QSTATWRVRI IPDGKYEASE
TFQIILSDPV MAALEFPKMA TADIIDPSDE STVYIPEPEY RIEENIGEFL IPIRRSGDIS
QELMVFCSTH QGTASGTIPS TVLSYSDYIS RPEDHTSILL FDKNKTEETC RVLIIDDSLY
EEEETFTVML SMPMGGQVGI SYPSTKVVIL KDVDDEPVLY FENTEYHIDE SAGSIEIGVW
RKGTDLSKPS TVTIQTRKTE PMSAEASMDY VGVSQSLDFV PGVNMKTFRV TILDDLGQPA
LEGPEKFELV LRMPMGSVIG EPSKATIIID DTITDLPKVQ FKKPSYTGNE KDGQVRAVIY
RNGDISHSST VRCYTRQGSA QVAVDYKERP NTDDSIVTFL PGETEKGCVV TLENDSIYEE
DEDFRLILGT PKSSSVFGAL VGEQKEVLIR VKDEEDKPVI KFSKVKYTVQ EPQHPRKTAV
LRIPVVRLGD TSKVSIVRIH TKDGSATSGE DYNPVSEDIE FKEGEAKHFV EIEVLYDGIK
EMREALTVHL KPDENMVAEI QINKAIVYIE EMDSLADVTF PAVPQVVSLL MYDDTSATIE
KSSPPTGYPV VCVTACNPKY LDYDKTGSIC TSENINDTLT LYRWLVGAPT SNNGVTSLMQ
EVNANTFFTN TKSIALDSLY FQAGSRVQCA ARAVSMSGDV GLELLSSIIT ISQDDGFCQP
YMPGTVGAKP FSAKIHYTGP DDPDYPNLIK LTVMMPHLDG MLPVISTQPL SNFELTLSPD
ATRVGNHKCS NLLDSSEIQT KHGFITNYSR NADGIREALP YQDDTSLRSA QTLRFYHNLN
LDACLWEFNS YYDVSELLTA CGGSVSTDGQ VLNLVQSYVT LRVPLFVSYV FHSPEATGGW
KHFDLQSELR LTFVYDTSIL WKEGIGSLPE SELQGTLHPI SMRINEEGRL VVNFQTKIHF
QGQLVMSHPG TALSSMVMSV DHPGLTFTLS LLRSEPTFHQ PEQRWTFVSG FAIRDYSGTY
TIKLLPCVAA PQQKYSLPMI CHPWEPLTFD LVIRFQQVSD PVATEFSLNT RMFLLSKKEL
WISNDSMDFA EGSDVAFPEG STIYGRVMVD PVQNLGDAFT CNIEQVFLCT GVDGYVPKYS
PEHKAYGCLA DSSSLLYRFK ILDRAQPETQ ARRFQNVSFD AHLATDQVDA LPLVKQPGSD
GFSLSSAALF QVAASREWYL HAVYTVRSRE NAKKSIGKRS TDHMPARARG PSTALSLNRS
QRAASDAPTL AQDIGADDSR GTNIQHVVLV RSVAPVFSHK DSLPPGTQGQ QPELEMAEAK
MQSGAGPILG AGGSLLLLSC IALVAVFLLR HRKRGPLGKD APSNRKTPTS QHSSSEV
//
