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Database: UniProt
Entry: F6VC27_HORSE
LinkDB: F6VC27_HORSE
Original site: F6VC27_HORSE 
ID   F6VC27_HORSE            Unreviewed;       896 AA.
AC   F6VC27;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   31-JUL-2019, entry version 67.
DE   SubName: Full=Vav guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSECAP00000013261};
GN   Name=VAV1 {ECO:0000313|Ensembl:ENSECAP00000013261,
GN   ECO:0000313|VGNC:VGNC:24888};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013261, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000013261, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013261,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000013261}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013261};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   Ensembl; ENSECAT00000016417; ENSECAP00000013261; ENSECAG00000014896.
DR   VGNC; VGNC:24888; VAV1.
DR   eggNOG; KOG2996; Eukaryota.
DR   eggNOG; ENOG410XPH6; LUCA.
DR   GeneTree; ENSGT00940000159125; -.
DR   Proteomes; UP000002281; Chromosome 7.
DR   Bgee; ENSECAG00000014896; Expressed in 3 organ(s), highest expression level in liver.
DR   ExpressionAtlas; F6VC27; baseline.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00029; C1; 1.
DR   CDD; cd01223; PH_Vav; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd10405; SH2_Vav1; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR022613; CAMSAP_CH.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037832; PH_Vav.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR003096; SM22_calponin.
DR   InterPro; IPR028530; Vav1.
DR   InterPro; IPR035879; VAV1_SH2.
DR   PANTHER; PTHR45818:SF2; PTHR45818:SF2; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF11971; CAMSAP_CH; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00888; SM22CALPONIN.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Guanine-nucleotide releasing factor {ECO:0000256|SAAS:SAAS01163629};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00253054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
KW   ECO:0000256|SAAS:SAAS01042643}; Zinc {ECO:0000256|SAAS:SAAS00253075}.
FT   DOMAIN        1    119       Calponin-homology (CH).
FT                                {ECO:0000259|PROSITE:PS50021}.
FT   DOMAIN      194    373       DH. {ECO:0000259|PROSITE:PS50010}.
FT   DOMAIN      402    504       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      515    564       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      649    743       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   DOMAIN      760    820       SH3. {ECO:0000259|PROSITE:PS50002}.
FT   REGION      568    589       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    571    589       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   896 AA;  103394 MW;  7B6CEB855144E554 CRC64;
     MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV
     NLRPQMSQFL CLKNIRTFLS TCGEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI
     AQNKGIMPFP TEDESVGDED IYNGLSDQID DTVEEDEDLY DCVENEEAEG DEIYEDLMRS
     EPVPMLPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF MKPLQRFLKP QDIEIIFINI
     EDLLRVHTHF LREMKEALAT PSAPTLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVATA
     REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQDT VEKENLRLAL
     DAMRDLAQCV NEVKRDNETM RQITNFQLSI ENLDQSLAHY GRPKIDGELK ITSVERRSKM
     DRYAFLLDKA LLICKRRGDS YDLKDFVNLH SFQVRDDSSG ERDNKKWTHM FLLIEDQGAQ
     GYELFFKTRE LKKKWMEQFE MALSNIYPEN ATANGHDFQM YSFEETTSCK ACQMLLRGTF
     YQGYRCHRCR APAHKECLGR VPPCGRHGQD SAGTMKKDKP HRRAQDKKRN ELGLPKMEVC
     QEYYGLPPPP GAFGPFLRLN LGDIVELTKA EAEQNWWEGP PQDLSVHLWY AGPMERAGAE
     SILTNRSDGT FLVRQRVKDA AEFAISIKYN VEVKHIKIMT AEGLYRITEK KAFRGLVELV
     EFYQQNSLKD CFKSLDTTLQ FPFKEPERRA ISKPAAGSTK YFGTAKARYD FCARDRSELS
     LKEGDIIKIL NKKGQQGWWR GEIYGRVSWG ELGSLGKGRG GDPVMVERPW NCGMEKVGSG
     SRGGLPGRTG GRDISFHRDF IHLCNLHLFI AFIFYAPGIL LGAKETEKNP VQSLPS
//
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