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Database: UniProt
Entry: F6VDH4_ORNAN
LinkDB: F6VDH4_ORNAN
Original site: F6VDH4_ORNAN 
ID   F6VDH4_ORNAN            Unreviewed;       385 AA.
AC   F6VDH4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   16-OCT-2019, entry version 55.
DE   SubName: Full=Potassium voltage-gated channel subfamily J member 11 {ECO:0000313|Ensembl:ENSOANP00000012242};
GN   Name=KCNJ11 {ECO:0000313|Ensembl:ENSOANP00000012242};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000012242, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000012242}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000012242};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   STRING; 9258.ENSOANP00000012242; -.
DR   Ensembl; ENSOANT00000012244; ENSOANP00000012242; ENSOANG00000007682.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00970000193347; -.
DR   InParanoid; F6VDH4; -.
DR   OMA; GMYAVDY; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000007682; Expressed in 6 organ(s), highest expression level in heart.
DR   GO; GO:0008282; C:inward rectifying potassium channel; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR   GO; GO:0015272; F:ATP-activated inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
DR   GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050877; P:nervous system process; IEA:Ensembl.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003279; K_chnl_inward-rec_Kir6.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF44; PTHR11767:SF44; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01332; KIR62CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     72     96       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    103    121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    141    164       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       36    169       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      177    349       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      362    385       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   SITE        156    156       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   385 AA;  43098 MW;  05A38A3AFCBFC7F8 CRC64;
     MLSRKGIIPE EYVLTRLAED PAEPRYRARE RRARFVAKNG NCNVAHKNIR EQGRFLQDVF
     TTLVDLKWHH TLLIFTMSFL CSWLLFAMAW WLLAFAHGDL DRLVPCVTSI HSFASAFLFS
     IEVQVTIGFG GRMVTEECPL AILVLIVQNI VGLMVNAIML GCIFMKTAQA HRRAETLIFS
     KHAVIAVRHG RLCFMLRVGD LRKSMIISAT IHMQVVRKTT SPEGEVVPLH QVDIPMENGV
     GGNSIFLVAP LIIYHVIDSS SPLYDLAPGD LHHHEDLEVV VILEGVVETT GITTQARTSY
     LADEILWGRR FVPIVAEEDG RYSVDYSKFG NTVKVPTPAC TARQLEENRS LLDTLPLTSP
     KSQLRKRSVA GARAKPRFSI APDSS
//
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