ID F6VED7_XENTR Unreviewed; 327 AA.
AC F6VED7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000256|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000256|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000256|HAMAP-Rule:MF_03008};
DE AltName: Full=eIF-3-beta {ECO:0000256|HAMAP-Rule:MF_03008};
DE AltName: Full=eIF3 p36 {ECO:0000256|HAMAP-Rule:MF_03008};
GN Name=eif3i {ECO:0000313|Ensembl:ENSXETP00000011460};
GN Synonyms=EIF3I {ECO:0000256|HAMAP-Rule:MF_03008}, EIF3S2
GN {ECO:0000256|HAMAP-Rule:MF_03008};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000011460};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000011460}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000011460};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000011460}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C,
CC EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and
CC EIF3M. {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the WD repeat STRAP family.
CC {ECO:0000256|ARBA:ARBA00038394}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000256|HAMAP-
CC Rule:MF_03008}.
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DR AlphaFoldDB; F6VED7; -.
DR Ensembl; ENSXETT00000011460; ENSXETP00000011460; ENSXETG00000005247.
DR Xenbase; XB-GENE-974377; eif3i.
DR eggNOG; KOG1089; Eukaryota.
DR TreeFam; TF315197; -.
DR Bgee; ENSXETG00000005247; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19877; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I; 1.
DR PANTHER; PTHR19877:SF1; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03008};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_03008};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_03008}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 8..49
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 50..91
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 147..196
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 283..313
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 327 AA; 36760 MW; B8C7C84023D97DFE CRC64;
MRERPILLQG HERSITQIKY NRDGDLLFTV AKDPVVNVWY SVNGERLGTY SGHTGAVWCV
DVDWDTRHVL SGSADNSCRL WDCETGKQLA LLETNSAVRT CGFDFGGNII MFSTDKQMGY
QCFVSFIDLR DPTQIEDNEP YMKIPCSESK ITSAVWGPLG ENIIAGHENG ELNQYSAKSG
EIVNSIKEHS KQINDIQTSR DMTMFVTASK DCTSKLFDST SLEHQKTFRT ERPVNSAAIS
PIYDHVVLGG GQEAMDVTTT STRIGKFEAR FFHVAFEEEF GRVKGHFGPI NSLAFHPDGK
SYSSGGEDGY VRIHYFDPQY FDFEFES
//
