ID F6VEN0_HORSE Unreviewed; 1027 AA.
AC F6VEN0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 4.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Retinal guanylyl cyclase 1 {ECO:0000256|ARBA:ARBA00040311};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=GUCY2D {ECO:0000313|Ensembl:ENSECAP00000009869.4,
GN ECO:0000313|VGNC:VGNC:18663};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000009869.4, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000009869.4, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009869.4,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000009869.4}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000009869.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
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DR AlphaFoldDB; F6VEN0; -.
DR Ensembl; ENSECAT00000012492.4; ENSECAP00000009869.4; ENSECAG00000011645.4.
DR VGNC; VGNC:18663; GUCY2D.
DR GeneTree; ENSGT00940000161326; -.
DR HOGENOM; CLU_001072_1_0_1; -.
DR OrthoDB; 3683909at2759; -.
DR TreeFam; TF106338; -.
DR Proteomes; UP000002281; Chromosome 11.
DR Bgee; ENSECAG00000011645; Expressed in retina and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06371; PBP1_sensory_GC_DEF-like; 1.
DR CDD; cd14043; PK_GC-2D; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF228; RETINAL GUANYLYL CYCLASE 1; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Coiled coil {ECO:0000256|SAM:Coils}; Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vision {ECO:0000256|ARBA:ARBA00023305}.
FT TRANSMEM 469..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 472..812
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 884..986
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 821..848
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1027 AA; 111514 MW; DE95F0C1FE90AAE8 CRC64;
MTACALLAGG LPDPRLCAPA RWPRSPPGLL RTLPRPWPRL RLLLLLLLLP PSVLSAVFRV
GVLGPWACDP IFARARPELA ARLAAARLNH DPALEGGPRF EVALLPEPCR TPGSLGAVSS
ALARVSGLVG PVNPAACRPA ELLAQEAGVT LVPWGCPGTR AAGTTAPAVT PAADALYALL
REFRWAHVAL VTAPQDLWVE AGRALSTALR ARGLPVALVT SMEPSDLSGA REALRRVRDG
PRVRAVIMVM HSVLLGGEEQ RCLLEAAEEL GLADGSLVFL PFDTLHYALS PGPEALAVLA
NNSQLRRAHD AVLTLTRHCP PGGSVLDSLR RAQEHQELPS DLNLQQVSPL FGTIYDAVYL
LAGGVARARA AAGGSWVSGA AVAHHVRDAQ VPGFCGALGG AEEPQFVLLD TDAAGDRLFA
TYMLDPTRGS LWSAGTPVHF PRGGRGPGPD PWCWFDPDDI CNGGVEPRLV FIGFLLAVGM
GLAGVFLAHY VRHRLLHIQM ASGPNKIILT LDDITFLHPQ GGSSRKVIQG SRSSLAARSV
SDIRSVPSQP MDSSNIGLYE GDWVWLKKFP GDQHIAIRPA TKTAFSKLRE LRHENVALYL
GLFLAGGSSG AAAPREGMLA VVSEHCARGS LHDLLAQRDI KLDWMFKSSL LLDLIKGMRY
LHHRGVAHGR LKSRNCVVDG RFVLKVTDHG HGRLLEAQKV LPETPSAEDQ LWTAPELLRD
PALERQGTLA GDVFSLGIII QEVVCRSTPY AMLELTPEEV VQRLQSPPPL CRPSVSMDQA
PMECIQLMKQ CWAEQPDLRP SMDRTFDLFK SINKGRKTNI IDSMLRMLEQ YSSNLEDLIR
ERTEELELEK QKTDRLLTQM LPPSVAEALK MGTPVEPEYF EEVTLYFSDI VGFTTISAMS
EPIEVVDLLN DLYTLFDAII GSHDVYKVET IGDAYMVASG LPQRNGQRHA AEIANMALDI
LSAVGSFRMR HMPEVPVRIR IGLHSGKPRP FGAPPHLPLW GRLHISYTGG KLVGWVGEGT
CLEASFA
//
