ID F6VG21_XENTR Unreviewed; 474 AA.
AC F6VG21;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN Name=rnf217 {ECO:0000313|Ensembl:ENSXETP00000047224,
GN ECO:0000313|RefSeq:XP_004914658.1,
GN ECO:0000313|Xenbase:XB-GENE-987824};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000047224};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000047224}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000047224};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000047224}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_004914658.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_004914658.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_004914658.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR RefSeq; XP_004914658.1; XM_004914601.4.
DR Ensembl; ENSXETT00000047224; ENSXETP00000047224; ENSXETG00000021840.
DR GeneID; 100379757; -.
DR KEGG; xtr:100379757; -.
DR AGR; Xenbase:XB-GENE-987824; -.
DR CTD; 154214; -.
DR Xenbase; XB-GENE-987824; rnf217.
DR eggNOG; KOG1815; Eukaryota.
DR HOGENOM; CLU_608282_0_0_1; -.
DR OMA; RCPITEC; -.
DR OrthoDB; 2943236at2759; -.
DR TreeFam; TF330860; -.
DR Proteomes; UP000008143; Chromosome 5.
DR Bgee; ENSXETG00000021840; Expressed in 4-cell stage embryo and 10 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20342; BRcat_RBR_RNF217; 1.
DR CDD; cd20350; Rcat_RBR_RNF217; 1.
DR CDD; cd16622; vRING-HC-C4C4_RBR_RNF217; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047551; BRcat_RBR_RNF217.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047552; Rcat_RBR_RNF217.
DR InterPro; IPR047550; RNF217_RBR_vRING-HC.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685:SF478; E3 UBIQUITIN-PROTEIN LIGASE RNF217; 1.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT TRANSMEM 431..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..410
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 474 AA; 53114 MW; 1E3695645F627D08 CRC64;
MGMGDQHEEP HNTGNTGSSE EEADEEEEED GGRERGQIPP ASDRVSAIAY DDRELATSVD
CEEHRVDSIS AVHYEGPLAS CYPDTPPSDR DIEAVGCQPG AGTVSRAQGG GSIAVKTRKR
CSVLCTVYCV ESDLSSDLPP LYHIDEGSLP ELPTRASRLS STGELALSPT SLELELSPIL
ISNVGDSALK VMMSCRVCLE DRSLKPLPCC KKPVCDECLK RYLSSQVQLG QAEIRCPITE
CNKHLDESTI LYSLPHDDII KYKYFLELSR VDSSTKPCPQ CKHFTTFRSK THIPNLTKSE
NKLKIQCPSC QFIWCFKCHA PWHEGVNCRE YKKGDKLLRH WANEIEHGQR NAQKCPRCKV
HIQRTEGCDH MTCSQCNTNF CYRCGERYRQ LRFFGDHTSN LSIFGCKYRY LPERPHVRRL
VRGSVCAGKL LIAPLLIVLG LVLGALAIVI GLFGLPIYCL CKKQRKRTRT GMPW
//
