ID F6VGJ2_MACMU Unreviewed; 1258 AA.
AC F6VGJ2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Cytoplasmic linker associated protein 2 {ECO:0000313|Ensembl:ENSMMUP00000002639.4};
GN Name=CLASP2 {ECO:0000313|Ensembl:ENSMMUP00000002639.4,
GN ECO:0000313|VGNC:VGNC:84201};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000002639.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000002639.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000002639.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6VGJ2; -.
DR Ensembl; ENSMMUT00000002795.4; ENSMMUP00000002639.4; ENSMMUG00000031438.3.
DR VEuPathDB; HostDB:ENSMMUG00000031438; -.
DR VGNC; VGNC:84201; CLASP2.
DR eggNOG; KOG2956; Eukaryota.
DR GeneTree; ENSGT00940000155574; -.
DR TreeFam; TF101155; -.
DR Proteomes; UP000006718; Chromosome 2.
DR Bgee; ENSMMUG00000031438; Expressed in dorsolateral prefrontal cortex and 22 other cell types or tissues.
DR ExpressionAtlas; F6VGJ2; baseline.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF30; CLIP-ASSOCIATING PROTEIN 2; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR SMART; SM01349; TOG; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 84..317
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 612..849
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1015..1251
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 842..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1258 AA; 137251 MW; 0619723A6F8964A2 CRC64;
MAMGDDKSFD DEESVDGNRP SSAASAFKVP APKTSGNPVN SARKPGSAGG PKVGGASKEG
GAGAVDEDDF IKAFTDVPSV QIYSSRELEE TLNKIREILS DDKHDWDQRA NALKKIRSLL
VAGAAQYDCF FQHLRLLDGA LKLSAKDLRS QVVREACITV AHLSTVLGNK FDHGAEAIVP
TLFNLVPNSA KVMATSGCAA IRFIIRHTHV PRLIPLITSN CTSKSVPVRR RSFEFLDLLL
QEWQTHSLER HAAVLVETIK KGIHDADAEA RVEARKTYMG LRNHFPGEAE TLYNSLEPSY
QKSLQTYLKS SGSVASLPQS DRSSSSSQES LNRPFSSKWS TANPSTVAGR VSAGSSKASS
LPGSLQRSRS DIDVNAAAGA KAHHAAGQSV RNGRLGAGAL NPGSYASLGR VRAKLSAPLA
GMGNAKTDSR GRSRTKMVSQ SQPGSRSGSP GRVLTTTALS TVSSGVQRVL VNSASAQKRS
KIPRSQGCSR EASPSRLSVA RSSRIPRPSV SQGCSREASR ESSRDTSPVR SFQPLGPGYG
ISQSSRLSSS VSAMRVLNTG SDVEEAVADA LKKPARRRYE SYGMHSDDDA NSDASSACSE
RSYSSRNGSI PTYMRQTEDV AEVLNRCASS NWSERKEGLL GLQNLLKNQR TLSRVELKRL
CEIFTRMFAD PHGKVFSMFL ETLVDFIQVH KDDLQDWLFV LLTQLLKKMG ADLLGSVQAK
VQKALDVTRE SFPNDLQFNI LMRFTVDQTQ TPSLKVKVAI LKYIETLAKQ MDPGDFINSS
ETRLAVSRVI TWTTEPKSSD VRKAAQSVLI SLFELNTPEF TMLLGALPKT FQDGATKLLH
NHLRNTGNGT QSSMGSPLTR PTPRSPANWS SPLTSPTNTS QNTLSPSAFD YDTENMNSED
IYSSLRGVTE AIQNFSFRSQ EDMNEPLKRD SKKDGGDSMC GGPGMSDPRA GGDATDSSQT
ALDNKASLLH SVPTHSSPRS RDYNPYNYSD SISPFNKSAL KEAMFDDDAD QFPDDLSLDH
SDLVAELLKE LSNHNERVEE RKIALYELMK LTQEESFSVW DEHFKTILLL LLETLGDKEP
TIRALALKVL REILRHQPAR FKNYAELTVM KTLEAHKDPH KEVVRSAEEA ASVLATSISP
EQCIKVLCPI IQTADYPINL AAIKMQTKVI ERVSKETLNL LLPEIMPGLI QGYDNSESSV
RKACVFCLVA VHAVIGDELK PHLSQLTGSK MKLLNLYIKR AQTGSGGADP TTDVSGQS
//
