ID F6VHH2_CALJA Unreviewed; 386 AA.
AC F6VHH2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Rhomboid domain containing 3 {ECO:0000313|Ensembl:ENSCJAP00000037268.2};
DE SubName: Full=Rhomboid domain-containing protein 3 {ECO:0000313|EMBL:JAB04093.1};
GN Name=RHBDD3 {ECO:0000313|EMBL:JAB04093.1,
GN ECO:0000313|Ensembl:ENSCJAP00000037268.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000037268.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000037268.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB04093.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Bladder {ECO:0000313|EMBL:JAB04093.1}, Cerebellum
RC {ECO:0000313|EMBL:JAB42085.1}, and Hippocampus
RC {ECO:0000313|EMBL:JAB15278.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000037268.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GAMT01007768; JAB04093.1; -; mRNA.
DR EMBL; GAMS01007858; JAB15278.1; -; mRNA.
DR EMBL; GAMP01010670; JAB42085.1; -; mRNA.
DR RefSeq; XP_002743690.1; XM_002743644.3.
DR RefSeq; XP_009007024.1; XM_009008776.2.
DR STRING; 9483.ENSCJAP00000037268; -.
DR Ensembl; ENSCJAT00000039367.4; ENSCJAP00000037268.2; ENSCJAG00000020040.5.
DR GeneID; 100408471; -.
DR KEGG; cjc:100408471; -.
DR CTD; 25807; -.
DR eggNOG; KOG2632; Eukaryota.
DR GeneTree; ENSGT00390000013711; -.
DR HOGENOM; CLU_060547_0_0_1; -.
DR OMA; CIGHNYH; -.
DR OrthoDB; 4642509at2759; -.
DR TreeFam; TF332785; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000020040; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0000165; P:MAPK cascade; IEA:Ensembl.
DR GO; GO:0032815; P:negative regulation of natural killer cell activation; IEA:Ensembl.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
DR GO; GO:0002673; P:regulation of acute inflammatory response; IEA:Ensembl.
DR GO; GO:0050708; P:regulation of protein secretion; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.20.1540.10; Rhomboid-like; 1.
DR InterPro; IPR022764; Peptidase_S54_rhomboid_dom.
DR InterPro; IPR035952; Rhomboid-like_sf.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR43066:SF16; RHOMBOID DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR43066; RHOMBOID-RELATED PROTEIN; 1.
DR Pfam; PF01694; Rhomboid; 1.
DR Pfam; PF00627; UBA; 1.
DR SUPFAM; SSF144091; Rhomboid-like; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..184
FT /note="Peptidase S54 rhomboid"
FT /evidence="ECO:0000259|Pfam:PF01694"
FT DOMAIN 326..359
FT /note="UBA"
FT /evidence="ECO:0000259|Pfam:PF00627"
SQ SEQUENCE 386 AA; 40569 MW; F9C3C3F6E86776A0 CRC64;
MHARGPHSPL FLSLPLASSV LMLLMSSLWL LGAGPSLVLA PELLLDPWQV HRLLTHALGH
TALPGLLLSL LLLPTLGWQQ ECHLGTLRFL HASALLALAS GLLAVLLAGL GVSGAAGGCG
YMPVHLGMLA GEGHRPRRPR GALPPWLPPW LLLALTPLLS SEPPFLQLLC GLLAGLAYAA
GAFRWLEPSE RQLQSLQEGI LCRTLAGCWP LRLLPIPSSL AELPVTHPAG VRPPIPGPLY
VASSDLWSHC EGSALPPPGL RPVQPTWEGS SEVGLDWAGA SFSPGTPMWE VLDEQMLQEG
IQASLLDRPS QGPQSPPWLS KSSVSSLRLQ QLEHMGFPTE QAVVALAATG RVEGAVSLLV
GGQVGTEALV TQGKGGPAYS EGPGPP
//
