ID F6VHI7_CALJA Unreviewed; 662 AA.
AC F6VHI7; U3CTL9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=EWS RNA binding protein 1 {ECO:0000313|Ensembl:ENSCJAP00000037266.3};
DE SubName: Full=RNA-binding protein EWS isoform 1 {ECO:0000313|EMBL:JAB29148.1};
GN Name=EWSR1 {ECO:0000313|EMBL:JAB29148.1,
GN ECO:0000313|Ensembl:ENSCJAP00000037266.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000037266.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000037266.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:JAB29148.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebral cortex {ECO:0000313|EMBL:JAB29148.1};
RX PubMed=25243066; DOI=10.1186/2047-217X-3-14;
RA Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
RA Moriyama E.N., French J.A., Norgren R.B.Jr.;
RT "De novo assembly of the common marmoset transcriptome from NextGen mRNA
RT sequences.";
RL Gigascience 3:14-14(2014).
RN [3] {ECO:0000313|Ensembl:ENSCJAP00000037266.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the RRM TET family.
CC {ECO:0000256|ARBA:ARBA00008448}.
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DR EMBL; GAMR01004784; JAB29148.1; -; mRNA.
DR STRING; 9483.ENSCJAP00000037266; -.
DR Ensembl; ENSCJAT00000039365.5; ENSCJAP00000037266.3; ENSCJAG00000019987.5.
DR eggNOG; KOG1995; Eukaryota.
DR GeneTree; ENSGT00940000154191; -.
DR OMA; QSTAHGY; -.
DR TreeFam; TF322599; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000019987; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd12533; RRM_EWS; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR InterPro; IPR034869; EWS_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR034870; TET_fam.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR23238; RNA BINDING PROTEIN; 1.
DR PANTHER; PTHR23238:SF3; RNA-BINDING PROTEIN EWS; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF00641; zf-RanBP; 1.
DR SMART; SM00360; RRM; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00322}.
FT DOMAIN 367..453
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 524..555
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 130..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..201
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..482
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..568
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 69139 MW; 18F62D3F97A08432 CRC64;
MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQQAYGQQ SYGTYGQPTD VSYTQAQTTA
TYGQTAYATS YGQPPTVEGT STGYTTPTAP QAYSQPVQGY GTGAYDTTTA TVTTTQASYA
AQSAYGTQPA YPAYGQQPAA TAPTRPQDGN KPTETSQPQS STGGYNQPSL GYGQSNYSYP
QVPGSYPMQP VTAPPSYPPT SYSSTQPTSY DQSSYSQQNT YGQPSSYGQQ SSYGQQSSYG
QQPPTSYPPQ TGSYSQAPSQ YSQQSSSYGQ QSSFRQDHPS SMGVYGQESG GFSGPGENRS
MSGPDNRGRG RGGFDRGGMS RGGRGGGRGG MGAGERGGFN KPGGPMDEGP DLDLGPPVDP
DEDSDNSAIY VQGLNDNVTL DDLADFFKQC GVVKMNKRTG QPMIHIYLDK ETGKPKGDAT
VSYEDPPTAK AAVEWFDGKD FQGSKLKVSL ARKKPPMNSM RGGMPPREGR GMPPPLRGGP
GGPGGPGGPM GRMGGRGGDR GGFPPRGPRG SRGNPSGGGN VQHRAGDWQC PNPGCGNQNF
AWRTECNQCK APKPEGFLPP PFPPPGGDRG RGGPGGMRGG RGGLMDRGGP GGMFRGGRGG
DRGGFRGGRG MDRGGFGGGR RGGPGGPPGP LMEQMGGRRG GRGGPGKMDK GEHRQERRDR
PY
//
