ID F6VJJ5_HORSE Unreviewed; 847 AA.
AC F6VJJ5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=cAMP regulated phosphoprotein 21 {ECO:0000313|Ensembl:ENSECAP00000020613.3};
GN Name=ARPP21 {ECO:0000313|Ensembl:ENSECAP00000020613.3,
GN ECO:0000313|VGNC:VGNC:15542};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020613.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020613.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020613.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020613.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020613.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005600892.1; XM_005600835.2.
DR RefSeq; XP_005600893.1; XM_005600836.2.
DR RefSeq; XP_014587282.1; XM_014731796.1.
DR RefSeq; XP_014587283.1; XM_014731797.1.
DR RefSeq; XP_014587284.1; XM_014731798.1.
DR RefSeq; XP_014587285.1; XM_014731799.1.
DR RefSeq; XP_014587286.1; XM_014731800.1.
DR RefSeq; XP_014587287.1; XM_014731801.1.
DR AlphaFoldDB; F6VJJ5; -.
DR STRING; 9796.ENSECAP00000020613; -.
DR PaxDb; 9796-ENSECAP00000020613; -.
DR Ensembl; ENSECAT00000024792.3; ENSECAP00000020613.3; ENSECAG00000022872.4.
DR GeneID; 100050660; -.
DR KEGG; ecb:100050660; -.
DR CTD; 10777; -.
DR VGNC; VGNC:15542; ARPP21.
DR GeneTree; ENSGT00940000160796; -.
DR HOGENOM; CLU_007817_1_0_1; -.
DR InParanoid; F6VJJ5; -.
DR OMA; SSGCVPY; -.
DR OrthoDB; 91945at2759; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000022872; Expressed in prefrontal cortex and 10 other cell types or tissues.
DR ExpressionAtlas; F6VJJ5; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR GO; GO:0034605; P:cellular response to heat; IEA:Ensembl.
DR CDD; cd02642; R3H_encore_like; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR024771; SUZ.
DR PANTHER; PTHR15672:SF14; CAMP-REGULATED PHOSPHOPROTEIN 21; 1.
DR PANTHER; PTHR15672; CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF12752; SUZ; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS51673; SUZ; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 164..227
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT DOMAIN 228..300
FT /note="SUZ"
FT /evidence="ECO:0000259|PROSITE:PS51673"
FT REGION 1..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..130
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..621
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 92984 MW; 3764EA6F13761E50 CRC64;
MSEQGDLSQA MVEGGGPEQE MATPENGIVK SESLDEEEKL ELQRRLEAQN QERRKSKSGA
GKGKLTRSLA VCEESSARPG GESLQDQESI HLQLSSFPSL QEDDKSRKDD SEREKEKDKN
KDKTSEKPKI RMLSKDCSQE YTDSTGIDLH EFLINTLKNN SRDRMILLKM EQEIIDFIGD
NNNHYKKFPQ MSSYQRMLVH RVAAYFGLDH NVDQTGKSVI INKTSSTRIP EQRFCEHLKD
EKGEESQKRF ILKRDNSSID KEDNQQNRMH PFRDDRRSKS IEEREEEYQR VRERIFAHDS
VCSQENLYVE NSRLLEDSNI CNETYKKRQL FRGNRDGSGR TSGSRQSSSE NELKWSDHQR
AWSSTDSDSS NRNLKPAMTK TASFGGITVL TRGDSTSSTR STGKLSKAGS SESSSSAGSS
GSLSRTHQPL QSAPLVSGVA ASSPGCLPYT ENGMGSQVAP SSTSYILLPL EAATGIPPGS
ILLNPHTGQP FVNPDGTPAI YNPPASQQPL RSSMVGQSQQ QPQQQPSPQP QQQVQPPQPQ
MAGTLVTQSV QGLQASSQSV QYPAVSFPPQ HLLPVSPTQQ FPLRDDVVTQ FSQMNLSRQS
SGETPEPPSG PVYPPSLMPQ PTQQPSYVIA SAGQQLPTGG FSGSGPPISQ QVLQAPPSPQ
GFVQQPPPAQ MPVYYYPSGQ YPTSTTQQYR PMASVQYSAQ RGQQMPQTAQ QAGYQPVLSG
QQGFQGLLGV QQPPQSQSVM SNQTGTPVQS VMVSYPTMSS YQVPMTQGSQ GLPQQSYQQP
IILPNQASQG SLPATGMPVY CNVTPPTPQN NLRLIGPHCP SSTVPVMSAS CRTNCASMSN
AGWQVKF
//
