ID F6VKZ1_MONDO Unreviewed; 406 AA.
AC F6VKZ1;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=WD repeat-containing protein 18 {ECO:0000256|RuleBase:RU369067};
GN Name=ARID3A {ECO:0000313|Ensembl:ENSMODP00000007019.2};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000007019.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000007019.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000007019.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as a component of the Five Friends of Methylated
CC CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by
CC methylated CHTOP, leading to desumoylation of ZNF148 and subsequent
CC transactivation of ZNF148 target genes. Component of the PELP1 complex
CC involved in the nucleolar steps of 28S rRNA maturation and the
CC subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. May
CC play a role during development. {ECO:0000256|RuleBase:RU369067}.
CC -!- SUBUNIT: Component of the 5FMC complex, at least composed of PELP1,
CC LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated
CC CHTOP and ZNF148. Interacts with NOL9. Component of the PELP1 complex,
CC composed of at least PELP1, TEX10 and WDR18. The complex interacts with
CC pre-60S ribosome particles. {ECO:0000256|RuleBase:RU369067}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|RuleBase:RU369067}. Nucleus, nucleoplasm
CC {ECO:0000256|RuleBase:RU369067}. Cytoplasm
CC {ECO:0000256|RuleBase:RU369067}. Dynein axonemal particle
CC {ECO:0000256|RuleBase:RU369067}. Note=Mainly found in the nucleoplasm,
CC with low levels detected in the cytoplasmic and chromatin fractions.
CC {ECO:0000256|RuleBase:RU369067}.
CC -!- SIMILARITY: Belongs to the WD repeat IPI3/WDR18 family.
CC {ECO:0000256|RuleBase:RU369067}.
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DR AlphaFoldDB; F6VKZ1; -.
DR Ensembl; ENSMODT00000007160.3; ENSMODP00000007019.2; ENSMODG00000005667.3.
DR GeneTree; ENSGT00940000160899; -.
DR HOGENOM; CLU_029749_0_0_1; -.
DR OMA; VNARIYT; -.
DR Proteomes; UP000002280; Chromosome 3.
DR Bgee; ENSMODG00000005667; Expressed in forelimb bud and 17 other cell types or tissues.
DR ExpressionAtlas; F6VKZ1; baseline.
DR GO; GO:0120293; C:dynein axonemal particle; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR045227; WDR18/Ipi3/RID3.
DR PANTHER; PTHR18763:SF0; WD REPEAT-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR18763; WD-REPEAT PROTEIN 18; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|RuleBase:RU369067};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW rRNA processing {ECO:0000256|RuleBase:RU369067};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 117..158
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 190..211
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 265..306
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 406 AA; 44099 MW; 88801CDB6F2B40CE CRC64;
MAAPVEVAVC TDSAGQLWNC AVWELHSGTS LHTYRGGQTG PRSLALLNGE HLLAGQLGKN
YICAWELQRK DQLQQKIVCP GLVTCLTAAP NGLYVLAGIA ESIYLWEVST GNLLAILNRH
YQDLSCLAFT DDSSHFLSGG KDCLALVWSL HSVLQVEQSK VPDPRHVWSQ HTLPITDLHC
GFGGPLARAA TASLDQTVKL WEISSGELLL SVLFDMAIMS VTMDLAEYHL FCGGTDGSVF
QVDLFSWPGQ REKTFRTEQE NGKLFKGHRN QVTCLSVSAD GSLLLSGSHD ETVRLWDIQS
KQCLRTVSHK GPVTNAFIVL APASMFNPDC KPALPLPKFS KNLLGTESSE GSGTEAVMLR
LGVHRQVGKQ KPRTPIGACD LPGHRIIVLE LMGPSGHLVT EAPRGE
//
