ID F6VPQ6_HORSE Unreviewed; 234 AA.
AC F6VPQ6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=IZUMO family member 2 {ECO:0000313|Ensembl:ENSECAP00000020875.3};
GN Name=IZUMO2 {ECO:0000313|Ensembl:ENSECAP00000020875.3,
GN ECO:0000313|VGNC:VGNC:51042};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000020875.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000020875.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020875.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000020875.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000020875.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Izumo family.
CC {ECO:0000256|ARBA:ARBA00009633}.
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DR AlphaFoldDB; F6VPQ6; -.
DR Ensembl; ENSECAT00000025104.3; ENSECAP00000020875.3; ENSECAG00000034333.3.
DR VGNC; VGNC:51042; IZUMO2.
DR GeneTree; ENSGT00390000015068; -.
DR HOGENOM; CLU_104457_0_0_1; -.
DR OMA; QPRMALQ; -.
DR TreeFam; TF337020; -.
DR Proteomes; UP000002281; Chromosome 10.
DR Bgee; ENSECAG00000034333; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029389; IZUMO.
DR InterPro; IPR042920; IZUMO2.
DR PANTHER; PTHR47745; IZUMO SPERM-EGG FUSION PROTEIN 2; 1.
DR PANTHER; PTHR47745:SF1; IZUMO SPERM-EGG FUSION PROTEIN 2; 1.
DR Pfam; PF15005; IZUMO; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..234
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040199206"
FT TRANSMEM 200..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 234 AA; 25875 MW; A80A1678E3AFF888 CRC64;
MPPALAVLLL CGLLARGRGC LQCEPAAQEA LSQLRAALGP ERFQHERLHA RAQALMLGME
GPFFRDYALN AFVGKVGIGD LELVASFLKN QTSHLMSSSL KAADGLGLWG ASHPTGISFS
PPDGPLLEEL VALRERVIKE LKKALRSYEL KGLQKEEVLD CLHCQKISPK CIKKKYCFVD
GQPRMTLQYQ KASGYWRNQA LFGTITSVCL AVFLFGIIVA SAMTYRQNRK LLLR
//
