GenomeNet

Database: UniProt
Entry: F6VPX6_XENTR
LinkDB: F6VPX6_XENTR
Original site: F6VPX6_XENTR 
ID   F6VPX6_XENTR            Unreviewed;      3621 AA.
AC   F6VPX6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUN-2019, entry version 64.
DE   SubName: Full=Laminin subunit alpha 3 {ECO:0000313|Ensembl:ENSXETP00000033055};
GN   Name=lama3 {ECO:0000313|Ensembl:ENSXETP00000033055,
GN   ECO:0000313|Xenbase:XB-GENE-984634};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000033055, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000033055}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000033055};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000033055}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AAMC01030622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01030623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01030624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01030625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01030626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01030627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01030628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01030629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8364.ENSXETP00000033055; -.
DR   PaxDb; F6VPX6; -.
DR   Ensembl; ENSXETT00000033055; ENSXETP00000033055; ENSXETG00000015102.
DR   Xenbase; XB-GENE-984634; lama3.
DR   eggNOG; KOG1836; Eukaryota.
DR   eggNOG; ENOG410YNSE; LUCA.
DR   GeneTree; ENSGT00940000155638; -.
DR   InParanoid; F6VPX6; -.
DR   OMA; WVAPPSY; -.
DR   TreeFam; TF335359; -.
DR   Reactome; R-XTR-2022090; Assembly of collagen fibrils and other multimeric structures.
DR   Reactome; R-XTR-3000157; Laminin interactions.
DR   Reactome; R-XTR-446107; Type I hemidesmosome assembly.
DR   Reactome; R-XTR-8874081; MET activates PTK2 signaling.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000015102; Expressed in 10 organ(s), highest expression level in mesonephros.
DR   GO; GO:0005604; C:basement membrane; IBA:GO_Central.
DR   GO; GO:0005610; C:laminin-5 complex; IBA:GO_Central.
DR   GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0001738; P:morphogenesis of a polarized epithelium; IBA:GO_Central.
DR   GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR   GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR   GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR   GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR   Gene3D; 2.60.120.1490; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR009254; Laminin_aI.
DR   InterPro; IPR010307; Laminin_dom_II.
DR   InterPro; IPR002049; Laminin_EGF.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR000034; Laminin_IV.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR038684; Laminin_N_sf.
DR   Pfam; PF00052; Laminin_B; 1.
DR   Pfam; PF00053; Laminin_EGF; 15.
DR   Pfam; PF02210; Laminin_G_2; 3.
DR   Pfam; PF06008; Laminin_I; 1.
DR   Pfam; PF06009; Laminin_II; 1.
DR   Pfam; PF00055; Laminin_N; 1.
DR   SMART; SM00181; EGF; 9.
DR   SMART; SM00180; EGF_Lam; 16.
DR   SMART; SM00281; LamB; 1.
DR   SMART; SM00282; LamG; 4.
DR   SMART; SM00136; LamNT; 1.
DR   SUPFAM; SSF49899; SSF49899; 4.
DR   PROSITE; PS01248; EGF_LAM_1; 7.
DR   PROSITE; PS50027; EGF_LAM_2; 16.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 3.
DR   PROSITE; PS51115; LAMININ_IVA; 1.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00814887};
KW   Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460,
KW   ECO:0000256|SAAS:SAAS00580772};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Repeat {ECO:0000256|SAAS:SAAS00814929};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29   3621       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003348913.
FT   DOMAIN       32    293       Laminin N-terminal. {ECO:0000259|PROSITE:
FT                                PS51117}.
FT   DOMAIN      294    352       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      353    422       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      423    466       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      528    578       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      580    618       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      619    663       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      664    716       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      718    763       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      764    816       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN      817    863       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1418   1463       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1464   1507       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1508   1556       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1557   1607       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1628   1806       Laminin IV type A. {ECO:0000259|PROSITE:
FT                                PS51115}.
FT   DOMAIN     1840   1886       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     1887   1942       Laminin EGF-like. {ECO:0000259|PROSITE:
FT                                PS50027}.
FT   DOMAIN     2891   3061       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     3268   3440       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   DOMAIN     3447   3619       LAM_G_DOMAIN. {ECO:0000259|PROSITE:
FT                                PS50025}.
FT   COILED     2123   2163       {ECO:0000256|SAM:Coils}.
FT   COILED     2196   2216       {ECO:0000256|SAM:Coils}.
FT   COILED     2269   2342       {ECO:0000256|SAM:Coils}.
FT   COILED     2350   2370       {ECO:0000256|SAM:Coils}.
FT   COILED     2385   2419       {ECO:0000256|SAM:Coils}.
FT   COILED     2429   2449       {ECO:0000256|SAM:Coils}.
FT   COILED     2517   2544       {ECO:0000256|SAM:Coils}.
FT   COILED     2611   2631       {ECO:0000256|SAM:Coils}.
FT   COILED     2648   2668       {ECO:0000256|SAM:Coils}.
FT   DISULFID    318    327       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    390    399       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    442    451       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    528    540       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    530    547       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    549    558       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    594    603       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    619    631       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    639    648       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    664    676       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    666    683       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    685    694       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    734    743       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    787    796       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    817    829       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    819    836       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID    838    847       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1418   1430       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1420   1437       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1439   1448       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1480   1489       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1532   1541       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1557   1569       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1559   1576       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1578   1587       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1859   1868       {ECO:0000256|PROSITE-ProRule:PRU00460}.
FT   DISULFID   1913   1922       {ECO:0000256|PROSITE-ProRule:PRU00460}.
SQ   SEQUENCE   3621 AA;  401448 MW;  9A9B1B7A2201C771 CRC64;
     ACRGAAGCSQ HFSWALLLLF CMTGRTSSQQ SVGFSLHPAS FNLAQGAKIR ATATCGEEES
     GPSPGGGVGT VPRMDLYCKL VGGPAATPGH TIQGQFCDFC NSADPGKAHP ISNAIDGTER
     WWQSPPLSLG LEYNKVNVTI DLGQLFHVAY VLIKFANSPR PDLWVLERSV DFGRTYSPWQ
     YFANSKIDCI NHFKKEAKQP ITRDDDVICT TEYSRIVPLE NGEIVVSLIN GRPGAKYFMD
     SPVLRDFTKA TNIRLRFLRT NTLLGHLISK AQRDPTVTRR YYYSIKDISI GGRCVCHGHA
     DTCTVRNSGN QNLYECRCQH NTCGEICDRC CPGFNQKSWQ PATIDSTNEC EPCNCHGHAS
     DCYYDADIDT RKGSLDIYGQ YRGGGVCINC QHNTAGVNCE RCAKGYYRPY GVPKEASHGC
     VPCSCSPDKA DGCEEGSGRC YCKPNFSGNN CERCAEGFYN FPVCTRAMAS IVLGGPGQHC
     VRGHCAWAAT DAQLKPLLTI MTCAPHFKFN RCCTCIYPTF HLKCQTDCKC KGPGTVNGNC
     DMQTGQCHCR AGFQGTACDR CSAGHFHYPF CQKCNCHPTG VVPEVCDPTG KCLCHFRAEG
     AQCDQCRPGY HSFPKCEECN CDMFGAADPS CGFNGQCRCR TNFAGLTCSQ CAPGFYNYPS
     CTPCQCSSQG SYQSTCDLVT GQCYCRPDAT GQRCDKCTSG SHDFPRCEGF SGECDPTGTL
     HIQDVCTTPG YCRCLPRVEG LTCNRCKPLY WNLARENPNG CADCMCEVQG TISGIGECHK
     TEGDCYCKTN VCSASCDTCK DGYYLLEARN YFGCKGCQCD LGGAISHLCS ESSGTCSCRD
     NVEGMKCNQP KSNYYFPDLY QIKFEIEDGT TPLGRDVRFG YDSTEFPGFS WRGYAQMTSI
     QNEVKLSVNV ERSNLNVFRI ILRYINFELH PITGRITAYQ SRSSKGKHAF VNSCTFQSKE
     IVFPPSKQPA FLTVPGKSFA EPFSLAPGNW NINLTVESVL LDYLVLLPSD FYEAPILQMR
     VTEPCTNTGH VGDNCLIYQH LTVDAFKCVL GTELKYMRRE GVTQPITIRQ AKHGLPTMAD
     ISGRQVDLYL WMNVPRVGSY VLLFEYANED DHHHVANVRI SNNPLSEARV NLYSCNYSFL
     CRSIVVDNMN RIAVFELISD VEIHLSASSV HFLLHKMCIV PAEEFFIEYA EPKVRCVAVY
     GRNPSQSPSC VQSSFYENPP LSLLLDPVKN SKGDSGQINI IHNSVKEPGP SAHWGNGVLL
     KSPQNQVTLS WRIPHAGRYV FIAQYYQTLS PMFPVLVHVN GGARWSGSFN ASFCPHLFGC
     RDLVVAGNRI ALDVTNPDLA VIVEVPLEKS LILEYVLLVP ADSYSHELLQ EKPVDKSYDF
     INICGLNSFY IDPVNSPGFC KDSARSLVVF YNDGALPCNC NLEGATNPTC SPYGGQCSCR
     ANIIGRRCSR CATGYYGFPH CRSCNCGSRL CDEVTGKCIC PPQTLKPKCE ICNQQSFSYH
     PLVGCEGCNC STVGVVQPTL SHCDGTSGQC KCKPRIVGRQ CDRCSPGHFH FPDCFPCDCN
     PKGTEPHICN PHTGTCLCKE NVIGKKCDVC RRGSFRLDSS NPSGCTTCFC FGATDICQSS
     NKYRKKLVDM RSWSLETSEQ ARVAVTYNPG SNSVVADVQE LPPSVHNLYW VAPESYLGEK
     ISSYGGYLTY QLKSFGLPNE GMVLLDKRPD VQLTGRQMSI VYVGPNNPLP DRLYYGRVQL
     IERNFRHASS NNMVSREELM IILSNLESLH IRGLYFSETQ RLTLGEVGLD DITTSGSGEI
     ASQVEICSCP SEYSGDSCQN CAPGHYRDNS GLFLGKCVPC MCNGHSNRCQ DGSGICINCL
     HDTTGDYCEF CKEGYTGNAT LGNCRLCPCP LSVPSNSFAT GCVGTGRNMR CMCKPGYAGV
     SCERCAPGYY GNPLKFGSSC QPCNCGNNGQ LRSCDPLTGG KSKCNGYGFY ILCPFLWMIS
     RTEMSAQICD LLTLQTLNCV TNVNQKLGVI AEQSFQQIYG HGRLDFDLSF FLFMASSLWH
     GSSYNLKVIE NTECFNEEPK DTDIDENDDC KYCIYLSILL TGLALRKKGP LVMNIYHDFL
     VFLGGGQRCK ACDGCVSSLL VDLARMVDEL NLVKLQLQNV KANTQALQQI GALEARIREV
     KLQHDSYISK LASQRLKVDK MGTETNTLEQ EITALLEKAK MNAKKYETIA LNAEETFRSG
     SQLLLTIDLL LKNINILIRQ IASAEGGTGS GDLGKNMAEA QRMLSEMRKR NFSSQKREAT
     IEKEEAKALL NRVKNQFQKH QDQNKNLIRD ITKSINDYEA KLNDLRAVLN EANGQIKQAN
     NINTDNAAVL QDIKNKVKDL TRQQKEATSH LNAAETSLGQ TDSMLRLLQK SKEEYEKLAA
     QLDGAKQELS EKVNTLSKAA SKEPLVIMAE KHAQSLQDLA NQLTEIKRNV SSEDLVRCAM
     DAASAYDSII NAVKEAEVAA NKAKDAADSA LGKVEKEDLP GKAKQSKADS EALLAQAKNA
     QKSLQDLNPE LEDIKDRLVE AKEKKDKLPG ELASVQNSID GIKRDDIDNL ITSANELVKN
     ANAITEDVED ELVPIKGDLE KLNLTIGTTQ SADYNEKLEE ASNSVKNLTG SLPDLFDAMN
     HINSLMPLAN ISESVSRIRE LIQQARDAAN KVVVPMRFNG TTGVEVRPPS NLEDLKAYTH
     LSFFLQRPAS RTDRRKRQLT PDMFVMYLGR KDASKDFIGL AVKDDKLMCV YNLGGNEAEI
     NVDPYVSQNN PDEAIMDHVV LERIYQYLSL NYTKSFTSTR PDPVAKYTTD VRRNMLLSLD
     PEDVVFYVGG YPSDFRPPSK MNFRNYIGCI ELDSLNQNGI SLYNFKRTFN LNTTLVQPCK
     SRDKNLYKEE SERSFFEGTG YASISSTLPT GRNLRYEQTI QTTTDEGVVF FAENGTSYIS
     LIIENGILVL QYRIESGTVQ KIKSTNGLVS DGNEHVLFQL IASKYILNPA NFRAAQSKTY
     YFVNTYYLGG IPAVLREHNY LRCVLERYNI QTAPFRGCVK NVKTPLSSAT FKETYGVSRR
     CSDDWNIVRS AEFARGGTLG LKSDGFTFPQ NFQTSFGFQT SQPSATLLSY TTQSRACNPL
     LHNGETFLEL DKQHEQSVKE KKDHFYSFIR FKLNLSLLKD FVTQSQGGRG ELYERVWFVS
     TGINKVIGSK EVFGTPTFLE KAVYNYIYKA ASRFVAPGIL RTAVGLEYSA FMAFKNWPLN
     PINCRRSNRK RQSNRSNAFL ASRCDGRNIS ISEVQYSHMS WSRHSRLVFL HSVPCSRSHF
     SLDVRTTESS GLIFLMTDKE ETSHLSLHIS KGRYVFSLST KGNKLKIRSQ DKYNDGKWHT
     VIFSWDGLSG RLVVDGLKAR KGTLMKYFGL EKMTSVRLGG VPSLKIKSVP KKSFSGCLKN
     LKLNGLALEG PSHTFAVTPC YDGSFEKGIF FAPDGGHVVI DNSFNWNMDF EIALNIRPQS
     QSGVLFHTGS KGQQLSLYME AGELILSADG DTGEVLVSLT PQRALCDGKW HIIKVSLKHN
     VVKLEVDKQL KQFVVPSSLT LNNPDAPLFL GGLPDALEVP RLPAKILFVG CMKNVKVNNK
     IINFSKMSTF SGAVSFSRCP A
//
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