ID F6VS26_MACMU Unreviewed; 1351 AA.
AC F6VS26; H9Z816;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=ATPase family AAA domain containing 2 {ECO:0000313|Ensembl:ENSMMUP00000026958.4};
GN Name=ATAD2 {ECO:0000313|Ensembl:ENSMMUP00000026958.4,
GN ECO:0000313|VGNC:VGNC:70154};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000026958.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000026958.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000026958.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; F6VS26; -.
DR Ensembl; ENSMMUT00000028808.4; ENSMMUP00000026958.4; ENSMMUG00000020467.4.
DR VEuPathDB; HostDB:ENSMMUG00000020467; -.
DR VGNC; VGNC:70154; ATAD2.
DR eggNOG; KOG0732; Eukaryota.
DR GeneTree; ENSGT00550000074694; -.
DR HOGENOM; CLU_001448_3_2_1; -.
DR TreeFam; TF314783; -.
DR Proteomes; UP000006718; Chromosome 8.
DR Bgee; ENSMMUG00000020467; Expressed in spermatocyte and 22 other cell types or tissues.
DR ExpressionAtlas; F6VS26; baseline.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd05528; Bromo_AAA; 1.
DR CDD; cd19517; RecA-like_Yta7-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR045199; ATAD2-like.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23069; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23069:SF4; ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 976..1031
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 42..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..255
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1178..1193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1351 AA; 153741 MW; 03E53DF2CE838A89 CRC64;
MVVLRSSLEL HNHSAASATD SLDLSNEFLS LEQIGRRRLR SAGAAQKQPV ATTAKAGDGS
SVKEVGTYHR TRALRALRKD AQNSSDSSFE KNVEITEQLG NDKVIPVTRS LRTRNIVQSS
EHLHEDNGDV EVRRSCRIRS RYSGVNQSML FDKLITNTAE AVLQKMDDMK KMRRQRMREL
EDLGVFNETE ESNLNMYTRG KQKDIQRTDE ETTDNQEGSV ESSEEGEDQE HEDDGEDEDD
EDDDDEDDED EEDGEDNQKR YYLRQRKATV YYQAPLEKPR HQRKPNIFYS GPASPARPRY
RLSSAGPRSP YCKRMNRRRH AIHSSDSTSS SSSEDEQHFE RRRKRSRNRA INRCLPLNFR
KDELKGMYKD RMKIGASLAD VDPMQLDSSV RFDSVGGLSS HIAALKEMVV FPLLYPEVFE
KFKIQPPRGC LFYGPPGTGK TLVARALANE CSQGDKRVAF FMRKGADCLS KWVGESERQL
RLLFDQAYQM RPSIIFFDEI DGLAPVRSSR QDQIHSSIVS TLLALMDGLD SRGEIVVIGA
TNRLDSIDPA LRRPGRFDRE FLFSLPDKEA RKEILKIHTR DWNPKPLDTF LEELAENCVG
YCGADIKSIC AEAALCALRR RYPQIYTTSE KLQLDLSSIN ISAKDFEVAM QKMIPASQRA
VTSPGQALST IVKPLLQSTV DKILEALQRV FPHAEFRTNK TLDSDISCPL LESDLAYSDD
DVPSVYDNGL SQKSSHKAKD NFNFLHLNRN ACYQPMSFRP RILIVGEPGF GQGSHLAPAV
IHALEKFTVY TLDIPVLFGV SATSPEETCA QVIREAKRTA PSIVYVPHIH LWWEIVGPTL
KATFTTLLQN IPSFAPVLLL ATSDKPHSAL PEEVQELFIR DYGEIFNVQL PGKEERTKFF
EDLILKQAAK PPISKKKAVL QALEVLPVAP PPEPRSLTAE EVKRLEEQEE DTFRELRIFL
RNVTHRLAID KRFRVFTKPV DPDEVPDYVT VIKQPMDLSS VISKIDLHKY LTVKDYLRDI
DLICSNALEY NPDRDPGDRL IRHRACALRD TAYAIIKEEL DEDFEQLCEE IQESRKKRGC
SSSKYAPSYY HVMPKQNSTL AGDKRSDPEQ NEKLKTPSTP MACSTPAQLK RKIRKKSKWY
LGTIKKRRKI SQAKDDSQNA MDHKIESDTE ETQDTSVDHN ETGNTGESSV EENEKQQNAS
ESKLELRNNS NTCNIENELE DSRKTTACTE LRREKTACNG DASSSQIIHI SDENEGKEMC
VLRMTRARRS QVEQQQLISV EKALAILSQP TPSLVVDHER LKNLLKTVVK KSRNYNIFQL
ENLYAVISQC IYQHLETFYK CSYGHINISL M
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