ID F6VSQ2_HORSE Unreviewed; 429 AA.
AC F6VSQ2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=F-box and WD repeat domain containing 4 {ECO:0000313|Ensembl:ENSECAP00000018073.3};
GN Name=FBXW4 {ECO:0000313|VGNC:VGNC:17966};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018073.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018073.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018073.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018073.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018073.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6VSQ2; -.
DR Ensembl; ENSECAT00000021901.3; ENSECAP00000018073.3; ENSECAG00000020477.3.
DR VGNC; VGNC:17966; FBXW4.
DR GeneTree; ENSGT00390000005029; -.
DR HOGENOM; CLU_034660_0_0_1; -.
DR TreeFam; TF325020; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000020477; Expressed in bone marrow and 22 other cell types or tissues.
DR ExpressionAtlas; F6VSQ2; baseline.
DR CDD; cd20090; F-box_FBXW4; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14381; DACTYLIN; 1.
DR PANTHER; PTHR14381:SF1; F-BOX_WD REPEAT-CONTAINING PROTEIN 4; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 21..67
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
SQ SEQUENCE 429 AA; 47747 MW; 88E04C7478EFDD6A CRC64;
MAAAAEEEAA TREPAGRPAA GPALWRLPEE LLLLICSYLD MQALGRLAQV CRWLRRFTSC
DLLWRRIARA SLNSGFTRLG TDLMPSVPVK ERVKVSQNWK LGHCREGILL KWRCSQMPWM
QLEGDSLYIS QANFILAYQF RPDGASLNRR PLGVFAGHDE DVCHFVLANS HIISAGGDGK
IGIHKIHSTF TVKYSAHEQE VNCVDCKGGI IVSGSRDRTA KLFRDRDGLL WALLTPKNLG
PQQEGRGWRE QAGAQRAGGC DHRGVLALGR GPAGPGTPGT SPLSCFLSDF SPQTQSGQLM
THLGSDFPPG AGVLDVMYES PFTLLSCGYD TYVRYWDLRT SVRKCVMEWE EPHDSTLYCL
QTDGNHLLAT GSSYYGVVRL WDRRQRACLH AFPLTSTPLS SPVYCLRFTT KHLYAALSYN
LHVLDFQNP
//
