ID F6VV52_MONDO Unreviewed; 1347 AA.
AC F6VV52;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 24-JAN-2024, entry version 74.
DE SubName: Full=Synapse defective Rho GTPase homolog 2 {ECO:0000313|Ensembl:ENSMODP00000000370.3};
GN Name=SYDE2 {ECO:0000313|Ensembl:ENSMODP00000000370.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000000370.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000000370.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000000370.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR RefSeq; XP_007480657.1; XM_007480595.2.
DR STRING; 13616.ENSMODP00000000370; -.
DR Ensembl; ENSMODT00000000377.4; ENSMODP00000000370.3; ENSMODG00000000311.4.
DR GeneID; 100012079; -.
DR KEGG; mdo:100012079; -.
DR CTD; 84144; -.
DR eggNOG; KOG1452; Eukaryota.
DR GeneTree; ENSGT01030000234635; -.
DR HOGENOM; CLU_005764_1_0_1; -.
DR InParanoid; F6VV52; -.
DR OMA; PMLKSPF; -.
DR OrthoDB; 2905108at2759; -.
DR TreeFam; TF323458; -.
DR Proteomes; UP000002280; Chromosome 2.
DR Bgee; ENSMODG00000000311; Expressed in kidney and 19 other cell types or tissues.
DR GO; GO:0097060; C:synaptic membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF1; RHO GTPASE-ACTIVATING PROTEIN SYDE2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 814..933
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 970..1185
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1262..1295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..227
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..451
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..802
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1347 AA; 147267 MW; BC9395E67E1FBBC4 CRC64;
MAEPLKRTWS RLRGKRAPRG VARPDRERAR PAEPRVPLAS LAPASPEGED TGPATPCALS
PRGSGYGSSF GSPLSRRPSS GGRVLLVEES PDLEDEDYYE NLPGPEGEGP VAPVAASAAS
SSAAGSSPGA GGGRLETGRL RSQLQEAYYL LIQAMHDLQQ VSPPQAPWTG LEGHRHPAAA
PPPPSPPPSP PPSAPPLLSS PPPLFPSLPP PSPPLPPPPP SPLPLSPLPR MRLLCGRSLE
SFPICGPSPL RRWSSDSAVP SSAPLATPPS SCAGRDGDAP EPRGGTMDSP GPGCASLAGP
AGCMGLLPSK RGNGTALIRN SGSSVSPFSD PAAPSGLHRS KGDVPEGPFF KPPVVTVKKL
QKWMYKGRLL SLGMKGRVSG SPAPKVLDTQ AAPQCLGALK MQESKTHPVP PDQRIMLSDL
IENVYMSSMK KRELKGLKDN ELNEQRSHNR ITVSKKRNWL HQSTLKSPNL EEESKKTQEV
THLFKSPSLS QHHRPKPVHK ATNSSTSRNY ALEFSEENDA DDEGEIWYNP IPEDDGHILY
SVASSGEPNS VNLGISTLTL KVSSGNDLAK TVRHVENLPF SPEHVNVQIA QPTEINQVDS
MYSAEFIQLK KQRFGFRTQD SSLVEESPPL KSITGPGIPI ATSKSELSTS ESSPPSPNPA
KKGGSINWSF PDKIKSPKTV RKLSMKMKKL PELSRKLSVK GTLGHIHSSH GPSSLSKCNC
PGRSHIITLP SGNTIPAAQR NVISRYHLDS SVSSQHSFPK ENSSSSKSTC KGGYLSDGDS
PELIIKSGKR GSENKHLRGK EVFPNSSNKT EIDIDAFRHY SFSDQPKCSQ YLSGLMSVHF
YGAEDLKPPR MDSKDVFCAI QVDSVNKART ALLTCRTTFL DMDHTFNIEI ENAQHLKLVV
FSWEPTPRRN RVCCHGTVVL PTLFRVTKTH QLAVKLEPRG LIYVKVTLME QWENSLPGLD
ANQEPVIFGV DVQKVVEKEN VGLMVPLLMQ KCIMEIEKRG CQVVGLYRLC GSAAVKKELR
EAFEKDSKAV GLCENQYPDI NVITGVLKDY LRELPSPLIT KQLYEAVLDA MAKNPLKMTG
NGCENDPNDS KHTVELLDCL PDIEKATLKM LLDHLKLVAS YHEVNKMTCQ NLAVCFGPVL
LSQRQETSPH NHRVFTDSKE LASALDFKKH IEVLHYLLQL WPVQRLNVKE PPGDWFPEQK
SLNCLRRKKQ RPHMLNLSVP EGSGVLRPRQ ARLDSPLSNR YAGDWSGCGE NYFVNPKENV
NEVDYDDVPS EDTESGEDCS KGDGPDTGAQ QPKPISKECP FQTYLAMQAI DSSVDRTVNL
KDLQESIDIL IGNLERELNK NKLNISV
//