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Database: UniProt
Entry: F6VV52_MONDO
LinkDB: F6VV52_MONDO
Original site: F6VV52_MONDO 
ID   F6VV52_MONDO            Unreviewed;      1347 AA.
AC   F6VV52;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   24-JAN-2024, entry version 74.
DE   SubName: Full=Synapse defective Rho GTPase homolog 2 {ECO:0000313|Ensembl:ENSMODP00000000370.3};
GN   Name=SYDE2 {ECO:0000313|Ensembl:ENSMODP00000000370.3};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000000370.3, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000000370.3, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA   Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA   Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA   Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA   Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA   Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA   Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA   Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA   VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA   Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA   Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA   Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA   D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA   Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA   Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA   Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA   Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA   Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA   Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA   Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA   Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA   Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA   Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA   Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA   Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA   Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA   Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA   Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA   Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT   coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000000370.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   RefSeq; XP_007480657.1; XM_007480595.2.
DR   STRING; 13616.ENSMODP00000000370; -.
DR   Ensembl; ENSMODT00000000377.4; ENSMODP00000000370.3; ENSMODG00000000311.4.
DR   GeneID; 100012079; -.
DR   KEGG; mdo:100012079; -.
DR   CTD; 84144; -.
DR   eggNOG; KOG1452; Eukaryota.
DR   GeneTree; ENSGT01030000234635; -.
DR   HOGENOM; CLU_005764_1_0_1; -.
DR   InParanoid; F6VV52; -.
DR   OMA; PMLKSPF; -.
DR   OrthoDB; 2905108at2759; -.
DR   TreeFam; TF323458; -.
DR   Proteomes; UP000002280; Chromosome 2.
DR   Bgee; ENSMODG00000000311; Expressed in kidney and 19 other cell types or tissues.
DR   GO; GO:0097060; C:synaptic membrane; IBA:GO_Central.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0046578; P:regulation of Ras protein signal transduction; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR   PANTHER; PTHR46150:SF1; RHO GTPASE-ACTIVATING PROTEIN SYDE2; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT   DOMAIN          814..933
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          970..1185
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          1..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          162..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          253..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          436..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          620..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          753..804
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1262..1295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        177..227
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..330
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..451
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        638..663
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        753..773
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        783..802
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1347 AA;  147267 MW;  BC9395E67E1FBBC4 CRC64;
     MAEPLKRTWS RLRGKRAPRG VARPDRERAR PAEPRVPLAS LAPASPEGED TGPATPCALS
     PRGSGYGSSF GSPLSRRPSS GGRVLLVEES PDLEDEDYYE NLPGPEGEGP VAPVAASAAS
     SSAAGSSPGA GGGRLETGRL RSQLQEAYYL LIQAMHDLQQ VSPPQAPWTG LEGHRHPAAA
     PPPPSPPPSP PPSAPPLLSS PPPLFPSLPP PSPPLPPPPP SPLPLSPLPR MRLLCGRSLE
     SFPICGPSPL RRWSSDSAVP SSAPLATPPS SCAGRDGDAP EPRGGTMDSP GPGCASLAGP
     AGCMGLLPSK RGNGTALIRN SGSSVSPFSD PAAPSGLHRS KGDVPEGPFF KPPVVTVKKL
     QKWMYKGRLL SLGMKGRVSG SPAPKVLDTQ AAPQCLGALK MQESKTHPVP PDQRIMLSDL
     IENVYMSSMK KRELKGLKDN ELNEQRSHNR ITVSKKRNWL HQSTLKSPNL EEESKKTQEV
     THLFKSPSLS QHHRPKPVHK ATNSSTSRNY ALEFSEENDA DDEGEIWYNP IPEDDGHILY
     SVASSGEPNS VNLGISTLTL KVSSGNDLAK TVRHVENLPF SPEHVNVQIA QPTEINQVDS
     MYSAEFIQLK KQRFGFRTQD SSLVEESPPL KSITGPGIPI ATSKSELSTS ESSPPSPNPA
     KKGGSINWSF PDKIKSPKTV RKLSMKMKKL PELSRKLSVK GTLGHIHSSH GPSSLSKCNC
     PGRSHIITLP SGNTIPAAQR NVISRYHLDS SVSSQHSFPK ENSSSSKSTC KGGYLSDGDS
     PELIIKSGKR GSENKHLRGK EVFPNSSNKT EIDIDAFRHY SFSDQPKCSQ YLSGLMSVHF
     YGAEDLKPPR MDSKDVFCAI QVDSVNKART ALLTCRTTFL DMDHTFNIEI ENAQHLKLVV
     FSWEPTPRRN RVCCHGTVVL PTLFRVTKTH QLAVKLEPRG LIYVKVTLME QWENSLPGLD
     ANQEPVIFGV DVQKVVEKEN VGLMVPLLMQ KCIMEIEKRG CQVVGLYRLC GSAAVKKELR
     EAFEKDSKAV GLCENQYPDI NVITGVLKDY LRELPSPLIT KQLYEAVLDA MAKNPLKMTG
     NGCENDPNDS KHTVELLDCL PDIEKATLKM LLDHLKLVAS YHEVNKMTCQ NLAVCFGPVL
     LSQRQETSPH NHRVFTDSKE LASALDFKKH IEVLHYLLQL WPVQRLNVKE PPGDWFPEQK
     SLNCLRRKKQ RPHMLNLSVP EGSGVLRPRQ ARLDSPLSNR YAGDWSGCGE NYFVNPKENV
     NEVDYDDVPS EDTESGEDCS KGDGPDTGAQ QPKPISKECP FQTYLAMQAI DSSVDRTVNL
     KDLQESIDIL IGNLERELNK NKLNISV
//
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