ID F6W187_HORSE Unreviewed; 789 AA.
AC F6W187;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Cadherin 9 {ECO:0000313|Ensembl:ENSECAP00000013963.3};
GN Name=CDH9 {ECO:0000313|Ensembl:ENSECAP00000013963.3,
GN ECO:0000313|VGNC:VGNC:16333};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000013963.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000013963.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013963.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000013963.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000013963.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; F6W187; -.
DR SMR; F6W187; -.
DR STRING; 9796.ENSECAP00000013963; -.
DR PaxDb; 9796-ENSECAP00000013963; -.
DR Ensembl; ENSECAT00000017214.4; ENSECAP00000013963.3; ENSECAG00000016167.4.
DR VGNC; VGNC:16333; CDH9.
DR GeneTree; ENSGT00940000160496; -.
DR HOGENOM; CLU_005284_3_1_1; -.
DR InParanoid; F6W187; -.
DR OMA; VIFDNDY; -.
DR OrthoDB; 3667774at2759; -.
DR TreeFam; TF329887; -.
DR Proteomes; UP000002281; Chromosome 21.
DR Bgee; ENSECAG00000016167; Expressed in prefrontal cortex and 2 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0034332; P:adherens junction organization; IBA:GO_Central.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central.
DR GO; GO:0044331; P:cell-cell adhesion mediated by cadherin; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF99; CADHERIN-9; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 1.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..789
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023862833"
FT TRANSMEM 615..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..159
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 160..268
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 269..383
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 384..488
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 488..605
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 789 AA; 88272 MW; 27D29945280733E6 CRC64;
MGAYHCLPLF IWTCVFHTVD SIPLQEKVSG DFPNKRIVGL TKDDGKMLHR TKRGWMWNQF
FLLEEYTGTD TQYVGKLHTD QDKGDGNLKY ILTGDGAGSL FVIDENTGDI HAAKKLDREE
KSLYILRAKA IDRKTGRQVE PESEFIIKIH DINDNEPKFT KELYTASVPE MSGVGTSVIQ
VTATDADDAN YGNSAKVVYS ILQGQPYFSV DPESGIIKTA LPDMSRENRE QYQVVIQAKD
MGGQMGGLSG TTTVNITLTD VNNNPPRFPQ STYQFNSPES VPLGTHLGRI KANDPDLGEN
AEIEYSIAEG DGADVFDVIT DKDTQEGIIT VKQNLDFEKK MLYTLRVDAS NTHPDPRFLH
LGPFKDTAVV KISVEDIDEP PVFSKISYLI EVDEDVKEGS IIGQVTAYDP DAVSNLIKYS
VDRHTDMDRI FSIHSENGSI FTLKTLDRES SPWHNITITA TEINNSKQSS QVPVFIRILD
INDHAPEFAM YYETFVCENA KPGQLIQTVS VMDKDDPPRG HKFFFEPVPE FPLNPNFTIV
DNKDNTAGIM TRKDGYSRNK MSTYLLPILI FDNDYPIQSS TGTLTIRVCA CDSEGNMQSC
SAEALVLTAG LSTGALIAIL LCVIILLVLV VLFAALKRQR KKEPLIISKD DVRDNIVTYN
DEGGGEEDTQ AFDIGTLRNP EAREDSKLRR DVMPETIFQI RRTVPLWENI DVQEFIHRRL
KENDSDPSAP PYDSLATYAY EGNDSIADSL SSLESLTADG NQDYDYLSDW GPRFKKLADM
YGGDDSDRD
//