ID F6W1M8_XENTR Unreviewed; 1990 AA.
AC F6W1M8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Structural maintenance of chromosomes flexible hinge domain-containing 1 {ECO:0000313|Ensembl:ENSXETP00000003388};
DE SubName: Full=Structural maintenance of chromosomes flexible hinge domain-containing protein 1 {ECO:0000313|RefSeq:XP_004915276.2};
GN Name=smchd1 {ECO:0000313|Ensembl:ENSXETP00000003388,
GN ECO:0000313|RefSeq:XP_004915276.2,
GN ECO:0000313|Xenbase:XB-GENE-968672};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000003388};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000003388}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000003388};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000003388}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_004915276.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_004915276.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_004915276.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_004915276.2; XM_004915219.4.
DR DNASU; 613097; -.
DR Ensembl; ENSXETT00000003388; ENSXETP00000003388; ENSXETG00000001609.
DR KEGG; xtr:100380032; -.
DR AGR; Xenbase:XB-GENE-961957; -.
DR AGR; Xenbase:XB-GENE-968672; -.
DR Xenbase; XB-GENE-968672; smchd1.
DR eggNOG; ENOG502QREW; Eukaryota.
DR HOGENOM; CLU_002288_1_0_1; -.
DR OMA; PRGEHIM; -.
DR OrthoDB; 4642592at2759; -.
DR TreeFam; TF329426; -.
DR Proteomes; UP000008143; Chromosome 6.
DR Bgee; ENSXETG00000001609; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR038892; SMCHD1.
DR PANTHER; PTHR22640:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR22640; UNCHARACTERIZED; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 1713..1840
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 1951..1990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1967..1982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1990 AA; 224646 MW; 9D3EB7D78F36303F CRC64;
MERGRQGPDS GAGSYKGRMV TLFDRRLEQT QCCEEKTLSV YGGGYAEFRA DMCQAFGIDP
EDQFVITTTD RKQVTHTNFD LIVQDGITLY LLQSPNQSLF SPTKEKIDFL PHYDTLVKSG
MYDYYASEGQ NPLPFALAEL IDNSLSASAQ NSGIRNIQIK LLFDEAQGKP AVVVTDNGKG
MNSTQLKNWA IYRLSKFTRG AAALSQGGSY VRPPHVPRSL NSDISYFGVG GKQAVFFVGQ
SARIITKTAD SQDVHEFVLS KEDFEKKEKN KEDIYSGFIR NRKPADSTHV TEDERFLHNL
IMEEDGKNQF TAVVITGVQT VHVQFLKNYY HLWSRQLAHI YHYYLHGPKG NYFNNRKSSS
LPSTNLDIEL SLFEKGKSPK IVNLREIKDD MQTLYINTAA DTFEFKALVE GEGVVEGVIR
YHPFLYHQET YPEDPYKTTR SSFEADYDDD CFIVEKEARG KRPIFECFWN GRLIPYTTVE
DFDWCAPPKK RGLCPPECYN RISGVLFTND KFQVSTNKLT FLDLGLKLQD KNTLFTRILK
GQEQRMKIDR EFAFWVKECH EKYDKQIKYI GFKGTITRTD IASKRMQSPW ATYSSIEWDR
KTYKAGQLVK TVKTVPVVYG SINRFLLYGD YESDIYATGG EVEISLEPKE LYDEIKCVPI
SKIDRNATLS IIKKYLEDEM TRFPDTLAVT WPEGDSLEEN DVIYAGSPIG PLRIEILNKK
GEPMQKLPGT GHAASKKLLV EMKVLINSSN GDKEIISHIS QHGGKWPYWF KKMENITKLG
NYTLKLQVVL NESNADTYAE KPLPCKNIKF KIVEGKPVGF SVGVMDPPFR VGIPFNIPLS
LLDEFGHSTS PVTDIKPLLE ASGLTMQYED LSTESGLIIK GVVAKGPVNN CQGKNFMLKV
VLPGLKEDFQ IIKIRLLPGP PKSIKVVPDK DVVVVDNGIP VCFHVEVLDE AGNVTTQPKL
VAECKFTGAE NLPTYTLDCS NSGTGKLTGP ALRVQNIKKA HILTAKIELP CCKDVPAVER
SLKLEPSTHV AKLDILSVDG EKAIQIKHQD EIEWIAGDTM QNLILQMYDE ADRNVTITSE
LAEKIKVNWT PNVNKENLIK GLLPDVEVAT LVKDIRYCQV SYHDDHVSLE SAFTVKPLPD
EPKHLKCKLT GTNTLQMGQE LKSEIVLMLV DQYGNQVQSL PSSCIQSLGV SGNTLVKSSL
KITYQEDTHS MIVAGIKFSV GPPGDKELCF AWRSFSSYLK LYLIAGPPAK LDLLDWPKSE
PFTVISGKQM ETPLIVQLCD EWGFQSPMPN VKIALIKDSV LKMSPQNQQQ KTNKDGQLNM
GMLTFSAPKG EYSIVIKALQ SKTQVENYTL KLTVLPDPDK PARVKFRFDQ EAELRAGSIF
PEFVVNVVSE EDTIIKKLNP ANCSMKIWKD PSSGGKPPAG VTPMFCSKFR DGDKEGWFYF
RDKMIPDRVG KYCIQFAFVA EKNMTLYSEQ ITVDVTPNKP VKLVPHPLPP TPTVSNVKAE
ASRTLVKNLW LKIVDEHNNL AGSNLNGKIT AKIICASEDI TEIPQFESKD DIIEFPFRKG
SAEISGLILS ENTTGKDSTE YKIMFTLLSP TIETKEIEPY YLTFIFYNDF EKQQQMASLT
KEKDQLSQTV KAYRCLFDTS KQLIGEIRCQ ANEAKAKEIH FKNELKKFKI EVSRNNEIEY
IESLIKAKSS EREVIFHKPR RTCSLTPYSK RSADILGKIA HLALIEDNEA AKVISWHMAS
DMDCVVTLTT EAARQIYKES QGHQQVLPLD SVYKKNLQWG RQLPHIRNGK SCFKALGNPV
FARDLLVFEK EYTEHCQIVF GMLLGDAIIL DNLESANHYR KQLVQFTFCP TLLTREGDRI
RSNGKFGGLQ NKAPPLDKLR GMVFGAPLPK EYDTIGTVID LLEQLRSTMY KTKSVNIELD
NELQILNSPD MLNKKAELDL QEKQLKVIEQ KLGLTPKNQG TRSANKPSEH DMSDCPIPSK
RSKRENVKRK
//