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Database: UniProt
Entry: F6W656_XENTR
LinkDB: F6W656_XENTR
Original site: F6W656_XENTR 
ID   F6W656_XENTR            Unreviewed;       354 AA.
AC   F6W656;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-MAY-2019, entry version 44.
DE   SubName: Full=Deoxyribonuclease I {ECO:0000313|Ensembl:ENSXETP00000028295};
GN   Name=dnase1 {ECO:0000313|Ensembl:ENSXETP00000028295,
GN   ECO:0000313|Xenbase:XB-GENE-5840004};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000028295, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000028295}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000028295};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000028295}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
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DR   EMBL; AAMC01047088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01047089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01047090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8364.ENSXETP00000028295; -.
DR   PaxDb; F6W656; -.
DR   Ensembl; ENSXETT00000028295; ENSXETP00000028295; ENSXETG00000012928.
DR   Xenbase; XB-GENE-5840004; dnase1.
DR   eggNOG; ENOG410J9U5; Eukaryota.
DR   eggNOG; ENOG410Z4MV; LUCA.
DR   GeneTree; ENSGT00950000182846; -.
DR   InParanoid; F6W656; -.
DR   OMA; FIREPFV; -.
DR   TreeFam; TF329541; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000012928; Expressed in 6 organ(s), highest expression level in gastrula.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004536; F:deoxyribonuclease activity; IBA:GO_Central.
DR   GO; GO:0004530; F:deoxyribonuclease I activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IBA:GO_Central.
DR   GO; GO:0000737; P:DNA catabolic process, endonucleolytic; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR016202; DNase_I.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF01033; Somatomedin_B; 1.
DR   PRINTS; PR00130; DNASEI.
DR   SMART; SM00476; DNaseIc; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   SUPFAM; SSF90188; SSF90188; 1.
DR   PROSITE; PS00524; SMB_1; 1.
DR   PROSITE; PS50958; SMB_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    354       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003344243.
FT   DOMAIN      317    354       SMB. {ECO:0000259|PROSITE:PS50958}.
SQ   SEQUENCE   354 AA;  39629 MW;  19D4214412468075 CRC64;
     LGAMKLLVLV AVTACFLQAG FSFKIASFNI QRFSMTKVDD PVVLELLIRI LSRYEVIAIE
     EVMNADNTAI ISLVKELSLA TKLNYNVLIS DHLGRSSYRE KYAYIYREDI VKPVEWYHYD
     DGCENCGTDS FIREPFVARF TSLTTVVKDF ALISIHTSPD YAVMEVDALY DAWVDAKQRL
     KMENILILGD YNAACSYVAA RHWPIIRLRH AEELAWLIGD KEDTTVSTNT NCAYDRMVAG
     GQQLQSGIIP GTAKAFNYHV AYDLTYEMAK AVSDHYPIEV ELYEDAFYNG QRFEPRGSIG
     IDGGLSLNGP CTCTGVDFTT CLGRCGAYSQ SFPCNCNAAC SDYVNCCKDY VGYC
//
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