ID F6W8D0_CIOIN Unreviewed; 951 AA.
AC F6W8D0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000007689.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000007689.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR EMBL; EAAA01002543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EAAA01002544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EAAA01002545; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6W8D0; -.
DR STRING; 7719.ENSCINP00000007689; -.
DR Ensembl; ENSCINT00000007689.3; ENSCINP00000007689.3; ENSCING00000003725.3.
DR GeneTree; ENSGT00940000169835; -.
DR HOGENOM; CLU_007105_5_1_1; -.
DR InParanoid; F6W8D0; -.
DR OMA; AQTCQQK; -.
DR TreeFam; TF320922; -.
DR Proteomes; UP000008144; Chromosome 7.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015485; F:cholesterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF209; OXYSTEROL-BINDING PROTEIN; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT REPEAT 43..75
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 76..108
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 165..197
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 227..327
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 461..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..904
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 108900 MW; 7FB72BED0E0BE020 CRC64;
KMEESEVKLL NLSRNGRHLE ILELLDAHPN IDINCKGKSK STYSWTALHL ASYFGHTEAV
KVLLSRGANP NIRNHTGDTA LHKASLTKRE EVVHCLLEHS SNPTIANDDR KTPSQVASDI
AIKNVLEAAE KVHVLKETEK FLQCLLGFRI SRYGSFVNMD TPDEHGNTAL HHAAMRDQRT
IAIVLLQHGV DPSKRNKQGE RACDVTMSSQ MKKILDVKPV RQNHNMVQRF EGPLMKKKRF
LSPRWHWVVL ERGVISYFAR RADAAVGSKR RFFKYLTEST VTTREDNNHG FVVRFFDGSF
HHLMVNQSNK PLINRQKWVD AIREHAEYSN HFVAADNVVD SDSESDDPII PIIDIKNIVQ
TAEVHQKVLQ THVEHLTPLI QNFCFHPGQL MPTHVLGKCH EILGSATDMM KEFQMCLNVM
QRQEQIRESK LLDECERNRV LQQSLQALAT QHHNLELTIE SQAGSASDED EFYDAISGDS
DDEDDVMNFE DVSLVEADEE PKYHAVTRGD YDPTINSDES QSKSETSSLA PVGGHRDRLA
CPMFSRDEFS IWHILRQCIG KELSKITMPV IFNEPLSFIQ RLCEYMEYSC LLERACNAED
SVQRMEYVAA FAVSALASQL DRLGKPFNPL LGETYGYERS DLGFTWVSEQ VSHHPPVSAF
HATGTKHPFT FHGSVHPKLK FWGKSVEIEP RGWVTLHLKN PDETYTWTNP KCSVHNIVVG
KLWIEQHGVM EITNHRTISE CYIILHPCWF KNDLNKVEAK IIDISKQTVR ILEGDWTKHL
YSFSVDAHER FVATATQTNN GTKQKSSRKK TQNSSTSSDD IASFMTSQDD DVMCRCLWEV
QERPDWSVEM YNMTRFAMSL NADESKGHAP TDSRLRPDIR ALENGDIDGA SGEKHRLEEK
QRSARKARGK KKAEWTPRWF ERRTNDATKS DDWIFNEKYL DSDWSKCPDI F
//
