ID F6WAZ9_HORSE Unreviewed; 1676 AA.
AC F6WAZ9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Signal induced proliferation associated 1 like 2 {ECO:0000313|Ensembl:ENSECAP00000006510.2};
GN Name=SIPA1L2 {ECO:0000313|Ensembl:ENSECAP00000006510.2,
GN ECO:0000313|VGNC:VGNC:22986};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000006510.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000006510.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006510.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000006510.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000006510.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSECAT00000008661.4; ENSECAP00000006510.2; ENSECAG00000008162.4.
DR VGNC; VGNC:22986; SIPA1L2.
DR GeneTree; ENSGT00940000157388; -.
DR HOGENOM; CLU_002127_0_2_1; -.
DR TreeFam; TF318626; -.
DR Proteomes; UP000002281; Chromosome 1.
DR Bgee; ENSECAG00000008162; Expressed in retina and 23 other cell types or tissues.
DR ExpressionAtlas; F6WAZ9; baseline.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR021818; SIPA1L_C.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF7; SIGNAL-INDUCED PROLIFERATION-ASSOCIATED 1-LIKE PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF11881; SPAR_C; 2.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 593..810
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 948..1024
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1325..1358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1612..1660
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 45..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1193..1211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1676 AA; 185353 MW; CDFE06DD39535F20 CRC64;
MSDPRQSQEE KHKLGRASSK FKDPPRIMQS DDYFVRKFKA INGNMGHATS LNASNSSESG
GPANGTPAVP KMGVRARVSE WPPKKDCSKD LACKALWESR SQTSYESVVS IMHNGQNDQS
DGQQEEQLDL DFVEAKYTIG DIFVHSPQRG LHPIRQRSNS DVTISDIDAE DVLDQNAVNP
NTGAALHREY GSTSSIDRQG LSGENFFAML RGYRVENYDH KAMAPFGFPE FCPCDPAVSP
SLHAAAQISR GEFVRISGLD YVDSALLMGR DRDKPFKRRL KPESVETSLF RKLRAVKSEH
ETFKFTSDLE DSRLERGVRP WNCQRCFAHY DVQSILFNIN EAMATRANVG KRKNITTGAS
AASQTQMPAG QPGNCESPLG SKEDLNSKEN LDADEGDGKS NDLVLSCPYF RNETGGEGDR
RIALSRANSS SFSSAESCSF ESSLSSHCTN AGVSVLEVPR ENQPIHREKV KRYIIEHIDL
GAYYYRKFFY GKEHQNYFGI DENLGPVAVS IRREKVEDAK EKEGSQFNYR VAFRTSELTT
LRGAILEDAI PSTARHGTAR GLPLKEVLEY VIPELSIPCL RQALNSPKVS EQLLKLDEQG
LSFQHKIGIL YCKAGQSTEE EMYNNETAGP AFEEFLDLLG QRVRLKGFSK YRAQLDNKTD
STGTHSLYTT YKDYELMFHV STMLPHMPNN RQQLLRKRHI GNDIVTIVFQ EPGALPFTPK
SIRSHFQHVF VIVQVHNPCT ENVCYSVGVS RSKDVPPFGP PIPKGVTFPK SAVFRDFLLA
KVINAENAAH KSEKFRAMAT RTRQEYLKDL AENFVTTATV DTSVKFSFIT LGAKKKEKVK
PRKDAHLFSV GAIMWHVIAR DFGQSADIEC LLGISNEFIM LIEKDSKNVV FNCSCRDVIG
WTSGLMSIKV FYERGECILL SSVDNCAEDV REIVQRLGIV TRGCETVEMT LRRNGLGQLG
FHVNFEGIVA DVEPFGFAWK AGLRQGSRLV EICKVAVATL THEQMIDLLR TSVTVKVVII
QPHDDGSPRR GCSELCRIPM VEYKLDSEGT PCEYKTPFRR NTTWHRVPTP ALQPLSRASP
VPGTPDRLQC QQLLQQAQAA IPRSTSFDRK LPDGTRSSPS NQSSSSDPGP GGSGPWRPPV
GYDGCQSPLL LEHQGSGPLE CEGAREREDT MEGSRHPETK WHGPPSKVLS SYKERALQKD
GSCKDSPNKL SHIGDKSCSS HSSSNTLSSN TSSNSDDKHF GSGDLMDPEL LGLTYIKGAS
TDSGIDTTPC MPTTVLGPVH LAGSRSMLHS RAEQWADSAD ISGPDDEQAK MYAVHSYAPA
ISAGSAADGS MGDLSEISSH SSGSHHSGSP SAHCSKNSGS LDTSKVYIVS HSSGQQVPGS
MSKPYHRQGA VNKYIIGWKK SEGSPPPEES EGTECQGLYG EMDLMATATQ HQTVVGDAVS
EAQHVLSKED FLKLMLPDSP LVEEGRRKFS FYGNLSPRRS LYRTLSDESI CSNRRGSSFG
SSRSSILDQA LPNDILFSTT PPYHSTLPPR THPAPSMGSL RSLDSDEELG LLCHHTSYLD
QRVASFCTLT DMQHGQGLEA AQELPLCVDP GSGKDFMDAT GEQSPSTLTG KVNQLELILR
QLQTDLRKEK QDKAVLQAEV QHLRQDNMRL QEESQTATAQ LRKFTEWFFN TIDKKS
//
