ID F6WCU4_CIOIN Unreviewed; 954 AA.
AC F6WCU4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=PIN domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000017766.3, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000017766.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F6WCU4; -.
DR STRING; 7719.ENSCINP00000017766; -.
DR Ensembl; ENSCINT00000017766.3; ENSCINP00000017766.3; ENSCING00000008706.3.
DR GeneTree; ENSGT00940000154566; -.
DR HOGENOM; CLU_011872_0_0_1; -.
DR InParanoid; F6WCU4; -.
DR OMA; CAMDGGT; -.
DR TreeFam; TF327119; -.
DR Proteomes; UP000008144; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005697; C:telomerase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0070034; F:telomerase RNA binding; IBA:GO_Central.
DR GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR InterPro; IPR019458; Est1-like_N.
DR InterPro; IPR045153; Est1/Ebs1-like.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15696:SF0; PINC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR Pfam; PF10374; EST1; 1.
DR Pfam; PF10373; EST1_DNA_bind; 1.
DR Pfam; PF13638; PIN_4; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144}.
FT DOMAIN 79..190
FT /note="Telomerase activating protein Est1-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10374"
FT DOMAIN 199..401
FT /note="DNA/RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF10373"
FT DOMAIN 848..923
FT /note="PIN"
FT /evidence="ECO:0000259|Pfam:PF13638"
FT REGION 434..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 108984 MW; 619FC5E44A7B4418 CRC64;
MSHTDDYSAK HTVSPEVKSI SAKRLYRRVV ECVRKLDLGR QHRRSLISLF HPEQVKLRHK
LREACERLMF TYSSDYGRKA EELLWRKVYY DVIHAVKSGR KHLLTQHHLQ PHFRQFLYSA
VGYYHYLLLR LQSKVKTDLV CIDLPLADKP LQRTTRRYDT EEKEIELWVK ATSYKILVCL
GDLSRYQMEF GGLKSRPNRF YQLALLTKPG MGMPHNQLAT LAGHQSWWGL TATYHYCRSL
YAEQSFGGAE GNLQKLLDRN KKLFYQLPTD ALDGIVSTKV YRKEHTRIFI ISFLYLCDLL
RPKTYSTDVE ISGLCKRLID ALHVCLNNMN LETDFIEEDL FEGDFSVEYI HGDIVFKICV
LCLMNVHDLQ ACRSNRSSAA IAFALAFFSH VLGHVCQQIT SDIKGFPIFS CTQKPKNRKV
KTFQMVAPTP RLMVSDHWSA APKSKKNKSR MLTRRRRRVS GAEDGNLSEG EDSIAAGDHA
SDSDPIDSSS EDDSSYTSSS GSGTRLSQED LSSQDEEDQF KTDENKVRGR SEKIEVQPPQ
PTLAVASLQD LSNKMFQVKR KCFQFLLIFC HHLSAHFSAF PSVSSNSRRN ITTPAIKPTP
PVEVTQPKIN EIINEEIKVE TGRFRILQVM SQYHCLTSVL KLLADWLSAN EGVVGACAKS
SRALWNRLVQ LVEVLPTEKL MLQIGKLLTP QVQQKVNLLK MSPWRQTIPL PEDYVIAKMN
AIKDPSSKSF IDTTLPYQSL TNLQQCMIRT CRLRHLCRTL ASMDDVEVDV INSDVTIGDE
HFAAPEEETV DPQMELEFKT LHIMAVEAMR KARMMKDMAA SRLRNEVQLL ETSLGAPKSR
DSALCLYLVV DTSSMSLELP HIRRLVASGR FLVVIPKTVI DGLDAIKKES QGARDAIRYL
ESELKKGNRF IRAQSKDEQV PGVDGEPPKL RRDDVDAWRF YRIVECCRFL IQAE
//
