ID F6WFZ5_HORSE Unreviewed; 389 AA.
AC F6WFZ5;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Serpin domain-containing protein {ECO:0000259|SMART:SM00093};
GN Name=LOC100051301 {ECO:0000313|Ensembl:ENSECAP00000018788.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000018788.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000018788.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018788.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000018788.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000018788.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
CC {ECO:0000256|ARBA:ARBA00006426}.
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DR AlphaFoldDB; F6WFZ5; -.
DR Ensembl; ENSECAT00000022717.3; ENSECAP00000018788.3; ENSECAG00000035510.3.
DR GeneTree; ENSGT00940000154520; -.
DR HOGENOM; CLU_023330_0_2_1; -.
DR OrthoDB; 3218836at2759; -.
DR TreeFam; TF352619; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000035510; Expressed in epithelium of bronchus and 7 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd19956; serpinB; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR PANTHER; PTHR11461:SF186; SERPIN B4; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:F6WFZ5};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 13..389
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 389 AA; 43978 MW; 7B5729408F30A4CA CRC64;
MNSLSAANTH FALDLFQQFK KSEKGNIFYS PLSITSALAM TYLGAQGNAA LQMGKVLHFN
KVADNTREGS ATTQVEKLGN VHDQFQKLLT ELMKPTDAYE LSIANRLYGE KKFQFQQEYV
ENVKKFYLAG VESADFINAA EESRKKINSW VESQTNGKIK DLLPYGSLSS AILVLVNAVY
FKGQWDEKFD KKRTVEEKFW LNKDTSKSVQ MMKQTRSFNF TDLEDMQAKI LEMPYNGKDL
SMILLLPNEV DGLKKLEEKL TAEKLIEWTS TQNMSKRLVN LYLPRFKLEE SYELKDIMMS
LGMLDSFSPQ DADFSGMTGS RGLAVSKILH KSFVEVNEEG TEAAAATGGV VGITSLPIYE
SFHCDHPFLF FIKHNKTNSI LFLGRISSP
//
